The Omicron variant was first identified in South Africa in November 2021. It has over 50 mutations compared to the original virus, including over 30 in the spike protein. Early reports found no unusual symptoms compared to other variants, with fatigue and body aches reported. Prevention focuses on vaccination, physical distancing, and hand washing. Risk factors include pre-existing medical conditions and suppressed immunity. Treatment involves rest, fluids, and steroids, while diagnosis uses PCR and antigen tests.