Extreme performance with Oracle SOA Suite 12.2, Coherence and Exalogic can be achieved by configuring the platform to take advantage of the Exalogic infrastructure and optimizing SOA Suite and Coherence settings. Key aspects include using Coherence caching to minimize database transactions, configuring optimal WebLogic and JDBC settings for InfiniBand networking, and tuning SOA Suite dehydration and caching properties. This provides significant performance gains over a traditional architecture.