This document discusses using compartmentalization to improve resilience to African Swine Fever (ASF) introductions. Compartmentalization involves defining an animal subpopulation with a different health status than the rest of the country through strict biosecurity and management practices. If ASF outbreaks in the country, the compartment's pig population retains its disease-free status. Key aspects of compartmentalization include meeting international animal health standards, allowing disease-free trade without downtime from outbreaks in other areas, and independence from disease status of small farms and wildlife. Effective compartmentalization requires national standards, governance, oversight, emergency response plans, and compartment-level risk analysis, biosecurity, surveillance, and traceability.