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Share the Vision 2015  •    1
PROGRAM OF EVENTS
OCTOBER 8, 2015
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
INNOVATION & START-UP SHOWCASE
OTM_STV-DIR_0
Program of Events
FACULTY PRESENTATIONS 	 04
POSTER SESSION 	 20
START-UP PRESENTIONS 	 24
SHARE THE VISION  ·  OCTOBER 8, 2015
University of Illinois at Urbana-Champaign Innovation & Start-Up Showcase
Hosted by the Office of Technology Management and the University of Illinois Research Park
4  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Faculty Presenters
SHOWN IN ORDER OF PRESENTATION
Share the Vision 2015  •  Faculty Presentations  5
Martin Burke
CHEMISTRY
A BILLION YEAR HEAD START
ABSTRACT: Natural products represent a billion year head start
in the process of discovering new medicines, and most of this
potential remains untapped. The problem is that the process of
making such complex molecules and their derivatives is difficult
and slow, and this bottleneck precludes practical access to the
full range of this untapped functional potential. REVOLUTION
Medicines has exclusively licensed from UIUC an automated
building block-based synthesis platform initially developed in my
lab that for the first time enables practical, generalized access
to complex natural products and their derivatives for medicinal
chemistry. The company is now advancing and harnessing its
REVBLOCKS platform to redesign evolution’s products into new
medicines for treating serious human diseases.
RESEARCH: Development of molecular prosthetics as a general
strategy for the understanding and improvement of human
health where small molecules with the capacity to perform
protein-like functions can serve as substitutes for missing or
dysfunctional proteins.
HONORS: } Elias J. Corey Award for Outstanding Original
Contribution in Organic Synthesis by a Young Investigator, 2013
} Arthur C. Cope Scholar Award, American Chemical Society
(ACS), 2011 } Howard Hughes Medical Institute Early Career
Scientist, 2009
START-UP COMPANY: REVOLUTION Medicines: developing
new therapies through an innovative approach that reconfigures
natural substances into best-in-class medicines. The company
launched in 2015 with a $45 million investment from Third Rock
Ventures. (www.revolutionmedicines.com)
LICENSES: Professor Burke’s MIDA boronates, which enable
diverse arrays of small molecules to be generated simply and
quickly by repeatedly using a single reaction to join different
organic sub-units, have been licensed to Sigma Aldrich,
BoroPharm, and Ally Chem. More than 130 MIDA boronates are
now commercially available and these building blocks are being
widely utilized to promote the discovery of new medicines by
more than 70 pharmaceutical companies around the world.
Healthcare:
Therapeutics
6  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Jianjun Cheng
MATERIALS SCIENCE
& ENGINEERING
SELECTIVE CELL LABELING AND CANCER TARGETING
ABSTRACT: Cell surface protein receptors play a vital role in
regulating the interaction between cells and the extracellular
environment, especially the influx and efflux of materials
including therapeutic agents. The differentiation of cell surface
protein receptors between normal and diseased cells will
potentially enable targeted delivery of therapeutic agents into the
diseased cells and thus minimize undesired side effects. However,
the difference in the population of existing receptors between
diseased and normal cells in one individual is either too small
to impart good high selectivity or highly specific to certain cell
types. Our group recently developed a controlled labeling strategy
to label cell types of interest with chemical groups by using
chemically modified metabolic sugar precursors. This controlled
labeling strategy, coupled with various efficient Click chemistries,
can be used for diagnosis and treatment of diseases, especially
cancers. My presentation will cover basic chemistry design and
demonstration of the controlled labeling strategy and its key
properties and applications in cancer-targeted treatment.
RESEARCH: Developing functional molecular, polymeric and
nano-materials and exploring their applications in nanomedicine
for drug/gene delivery, imaging and diagnosis
HONORS: } Fellow, American Institute for Medical & Biological
Engineering (AIMBE), 2015 } Fellow, ACS-POLY, 2015 } NIH
Director’s New Innovator Award, 2010
Paul
Hergenrother
CHEMISTRY, CARLE WOESE
INSTITUTE FOR GENOMIC
BIOLOGY
TRAVERSING THE VALLEY OF DEATH IN ANTICANCER
DRUG DISCOVERY
ABSTRACT: Anticancer drug discovery is typically a lengthy,
expensive, and high-risk enterprise. Statistics show that even
after multiple years and millions of dollars, only 5% of candidates
that enter a Phase I trial in oncology gain FDA approval. We
have pioneered a strategy that enables us to more intelligently
choose drug candidates in a rapid and cost-effective manner.
In this strategy we evaluate drug candidates in pet dogs with
cancer, offering hope for these veterinary cancer patients and
their owners, and allowing us to optimize treatment parameters
in real cancer patients with heterogeneous tumor populations,
metastatic disease, etc.
A case study for this strategy will be presented, the discovery
and development of the anticancer drug PAC-1. PAC-1 selectively
induces cancer cell death though a novel mechanism, activation
of procaspase-3. The dosing, timing, and formulation of
PAC-1 was optimized through its evaluation in canine cancer
patients; over 50 dogs with cancer have been treated with
PAC-1 and its derivatives, and PAC-1 shows considerable
promise in some of the most difficult-to-treat canine cancers.
Largely on the basis of this dog data, the FDA approved our
Investigational New Drug application and PAC-1 is now being
taken by human cancer patients as part of a Phase I clinical trial
at the University of Illinois Cancer Center in Chicago, and at
Johns Hopkins University. For more information please see the
listing on clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/
NCT02355535
Share the Vision 2015  •  Faculty Presentations  7
RESEARCH: Using organic compounds to identify novel cellular
targets that can be exploited in the treatment of diseases
including cancer and drug-resistant bacteria.
HONORS: } Kenneth L. Rinehart Jr. Endowed Chair in Natural
Products Chemistry } Eli Lilly Award in Biological Chemistry, 2008
START-UP COMPANIES: Vanquish Oncology: developing
procaspase-3 activating compounds, known as PAC-1, as a cancer
therapeutic. The compound is now in Phase I clinical trials.
(www.vanquishoncology.com)
Douglas
Mitchell
CHEMISTRY, CARLE WOESE
INSTITUTE FOR GENOMIC
BIOLOGY
GENOMICS-ENABLED NATURAL PRODUCT DISCOVERY
ABSTRACT: Natural products have been, without question,
the most prolific source of all medicines, especially antibiotics.
Genome sequencing has revealed that our knowledge of natural
product structure and function is astonishingly incomplete.
Therefore, exploration of uncharted natural product chemical
space will undoubtedly lead to improved, and entirely new,
medicines. Against this backdrop, our group focuses on
elucidating the biosynthesis, structure, and function of natural
products. This talk will highlight our recent advances in genomics-
enabled natural product discovery while covering a few case
studies in enzymatic biosynthesis that could be exploited to
introduce new drug leads.
RESEARCH: Identifying and characterizing novel antibiotic
compounds through genome-mining, isolation and
characterization of novel natural products, and mechanistic
studies of key natural product biosynthetic enzymes.
HONORS: } Pfizer Award in Enzyme Chemistry (ACS Division
of Biological Chemistry), 2015 } National Fresenius Award,
Phi Lambda Upsilon (National Chemistry Honor Society),
2015 } NIH Director’s New Innovator Award, 2011 } Packard
Fellowship, 2012
David Kranz
BIOCHEMISTRY
A NEW GENERATION OF CANCER THERAPEUTICS:
T CELLS AND T CELL RECEPTORS
ABSTRACT: In the past two years there has been a large
investment (billions$) by venture firms and pharmaceutical
companies in the area known as adoptive cell therapies (ACT).
The goal of this new generation of cancer therapeutics is to
destroy tumors with very specific and potent agents, a patient’s
own T cells (i.e. one of the key types of white blood cells). The
investment in this strategy has been based on exciting, and
widely publicized, early clinical results. However, there remain
many questions about how the approach will be more broadly
applied to millions of patients. One avenue that our lab has
focused on over the past twenty years has been to engineer
improvements in the key molecule involved in the specific-cancer
targeting activity of T cells, the T cell receptor. Our lab’s work
8  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
has identified some of the parameters involved in improving both
protein- and cell-based therapeutics in this class of agents. The
technologies developed around these studies formed the basis
of two University of Illinois start-up companies, BioDisplay and
ImmuVen, which were acquired by pharmaceutical companies.
This presentation will discuss the science behind this work, and
its potential application toward helping cancer patients with
more efficacious treatments that have significantly reduced side
effects (e.g. compared to chemo).
RESEARCH: Understanding a fundamental issue in
immunology: how mammals can eliminate millions of different
antigens that are “foreign” (e.g. viruses, bacteria) without
destroying antigens that are “self” (e.g. one’s own tissues).
The specific focus of the lab is on the antigen-specific receptor
expressed by T lymphocytes (T cell receptor, TCR).
HONORS: } Phillip A. Sharp Professor of Biochemistry
START-UP COMPANY: BioDisplay: Developed yeast-display
methodology using flow cytometry to provide high-throughput
screening, which in turn speeds the process of directed drug
discovery. Immuven: developing new biotherapeutics to treat
cancer, infectious disease, and autoimmune disorders. The
platform allows rapid selection and optimization of T cell
receptors with high affinity to targets in cancer, infections, and
autoimmune pathways.
Share the Vision 2015  •  Faculty Presentations  9
Healthcare:
Medical Devices
John Rogers
MATERIALS SCIENCE
& ENGINEERING
MILLIMETER-SCALE WIRELESS WEARABLES
ABSTRACT: Advanced concepts in antenna design, hybrid
materials, computing platforms and energy harvesters form the
technology foundations for the world’s smallest wireless sensors.
This talk demonstrates these ideas through a family of wearable
systems configured to mount on the fingernails, for robust
operation over months of continuous use, without removal,
during normal daily activities. Application opportunities range
from authentication, hardware security and data transactions, to
personal health monitoring and UV sensing. Joint development
activities with two large corporate partners will be highlighted.
RESEARCH: Electronic materials for devices that have unusual
properties, including those that match the soft, curvilinear
surfaces of biological tissues. Applications in wearables,
advanced surgical tools, and other biomedical systems.
HONORS: } Elected to the National Academy of Sciences, 2015
} Smithsonian Award for American Ingenuity in the Physical
Sciences, 2013 } $500,000 Lemelson Prize, 2011 }MacArthur
Fellowship, 2009
START-UP COMPANIES: mc10: commercializing classes of
electronics that can fold, twist, and conform to three dimensional
surfaces. Applications range from wearable sports monitors to
advanced surgical tools, to disease management and others.
(www.mc10.com) Semprius: commercializing low cost, high
performance concentrator photovoltaic modules for utility
scale power generation. The company’s unique mirco-transfer
printing technology enables CPV modules with world-record
efficiencies. (www.semprius.com) X-celeprint: commercializing
a cost-effective and scalable manufacturing platform based
on micro-transfer printing for integrating micro-scale devices
such as lasers, LEDs, or integrated circuits onto non-native
substrates. (www.x-celeprint.com) Wearifi: creating the world’s
thinnest, smallest, most flexible, and most lightweight near-field
communication wearable device technology.
10  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Curtis
Johnson
BECKMAN INSTITUTE FOR
ADVANCED SCIENCE &
TECHNOLOGY
MECHANICAL IMAGING OF THE HUMAN BRAIN
ABSTRACT: Medical diagnostics have a long history of utilizing
the mechanical properties of tissues to identify the presence
of pathology through manual palpation. Our group harnesses
the inherent mechanical contrast in disease to noninvasively
characterize brain tissue through an imaging method called
magnetic resonance elastography. Pathology can result in
tissue stiffness and viscosity changes by an order of magnitude
relative to healthy tissue, thus making tissue mechanical
properties potentially very sensitive markers of tissue health.
This talk will discuss our development of the high-resolution
brain elastography method for applications in neurology and
neurosurgery in partnership with the Carle Foundation Hospital.
In particular, we will highlight the work in pre-surgical evaluation
of intracranial tumors and the medial temporal lobe in epilepsy.
RESEARCH: The development of novel imaging methods
for characterizing the structure, function, and health of
tissue, particularly interested the use of tissue mechanics for
applications in neurosurgery, neurology, and neuroscience.
HONORS: } Junior Fellow of the International Society for
Magnetic Resonance in Medicine } BRAIN Grand Challenges
Young Investigator Award, 2014
Paul Braun
MATERIALS SCIENCE &
ENGINEERING, BECKMAN
INSTITUTE FOR ADVANCED
SCIENCE & TECHNOLOGY
SENSOR MATERIALS FOR IN VIVO EXTENDED
CONTINUOUS GLUCOSE MONITORING
ABSTRACT: Diabetes is a worldwide epidemic, and as such,
extensive research efforts towards glucose measurement
technologies have been maintained for the last 3 decades.
Although continuous glucose monitoring (CGM) has garnered
considerable attention due to the advantages in maintaining
tight glycemic control, successes in continuous monitoring have
been limited, and thus today, most glucose monitoring is still
performed using single use test strips. CGM requires sensors with
high precision, accuracy, sensitivity and stability, and if possible,
a linear response, characteristics that prior to our developments
have not been demonstrated in a sensor material. We have now
developed a new class of hydrogels that volumetrically respond to
glucose with the aforementioned features.
A photonic crystal is incorporated into such glucose responsive
hydrogel matrix as a signal transducer to convert the hydrogel
volume change into diffracted wavelength shift which is recorded
by a spectrometer, although other readout modalities are also
possible. The sensor materials meet key CGM requirements in
physiological buffer solutions and serum at body temperature.
Furthermore, miniaturized devices suitable for in vivo blood
glucose monitoring can be formed using such sensor materials.
Share the Vision 2015  •  Faculty Presentations  11
RESEARCH: The formation and study of nano and microstructured
materials through self and directed assembly. The Braun group uses
and develops new materials chemistry approaches to the synthesis
of these materials, which enables realization of novel form factors
of matter with advanced functionalities.
HONORS: } Friedrich Wilhelm Bessel Research Award, 2010
} Defense Science Study Group, 2010-2011
START-UP COMPANIES: Autonomic Materials: self-healing
technologies that extend coating lifetimes, minimizing upkeep
and repair. (www.autonomicmaterials.com) Xerion Advanced
Battery: developing next-generation ultra-high power, high
energy lithium ion batteries using scalable manufacturing
methods. (www.xerionbattery.com)
Stephen
Boppart
ELECTRICAL & COMPUTER
ENGINEERING, BIO-
ENGINEERING, BECKMAN
INSTITUTE FOR ADVANCED
SCIENCE & TECHNOLOGY
LABEL-FREE MULTIMODAL MULTIPHOTON IMAGING
FOR MOLECULAR HISTOPATHOLOGY
ABSTRACT: Multiphoton imaging provides three-dimensional
high-resolution imaging, and has been established as a powerful
technology in biomedicine. The most attractive aspect of
multiphoton imaging is the wealth of molecular contrast that
can be generated from various modalities. Coherent anti-
Stokes Raman/stimulated Raman scattering (CARS/SRS)
probes molecular vibrations, two-/three-photon fluorescence
(2PF/3PF) visualizes intrinsic fluorophores, and second/third
harmonic generation (SHG/THG) maps non-centrosymmetirc
media and heterogeneity. Integrating multiple modalities
enables label-free imaging of complementary endogenous
biomolecules, and is therefore highly desirable for biomedical
diagnostics. However, integration and further clinical translation
of these techniques are not trivial due to the complexity of the
laser(s) and the imaging system, and the compromises that
are often made for multiple modalities. We have developed a
solution that uses a compact ultrafast source to replace bulky
lasers, and a pulse processing device to arbitrarily tailor the
illumination pulses for multiple modalities. We demonstrate
an integrated multimodal multiphoton imaging platform using
fiber supercontinuum and pulse shaping. The high-quality fiber
supercontinuum is generated in a highly nonlinear all-normal-
dispersion fiber, achieving a spectrum spanning the optical
biological window with high coherence, high power, and long-
term stability. Adaptive pulse shaping of the supercontinuum
pulses enables high-performance CARS/2PF/SHG/3PF/
THG imaging of normal/cancerous human breast tissue, as
well as the longitudinal molecular/structural changes during
mammary tumor formation in a carcinogen-induced rat tumor
model. This multimodal multiphoton imaging platform offers
improved simplicity and expanded versatility, and the results
show a promising path for the translation and commercialization
of multiphoton imaging for molecular histopathology and
intraoperative surgical applications.
RESEARCH: Using light to image biological tissue and diagnose
disease. Using advanced imaging techniques such as optical
coherence tomography (OCT), nonlinear interferometric
vibrational imaging (NIVI), interferometric synthetic aperture
microscopy (ISAM), and multi-photon microscopy, it is feasible
to generate high-resolution, real-time, non-invasive images of
biological tissue at the cellular and molecular level for diagnosing
diseases such as cancer.
12  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
HONORS: } Abel Bliss Professor of Engineering } MIT
Technology Review’s Top 100 Young Innovators in the World,
} International Han Sigrist Prize in Laser Medicine, } Fellow of
AAAS, IEEE, OSA, SPIE, AIMBE
START-UP COMPANIES: Photonicare: developing a handheld
imaging tool that enables physicians to quickly and accurately
diagnose middle ear infections during routine examinations.
(www.photonicareinc.com) DiagnosticPhotonics: placing a
live view of tissue microstructure at the physician’s fingertips,
providing immediate insight that enables more informed
decisions and better care. (www.diagnosticphotonics.com)
Share the Vision 2015  •  Faculty Presentations  13
Robotics &
Computer Vision
Steven
LaValle
COMPUTER SCIENCE
VIRTUAL REALITY: WHAT’S IT GOOD FOR?
ABSTRACT: That is for you to figure out! You may have seen
articles appearing everywhere these days on virtual reality (VR)
technology and how it is poised to become the next great medium
or platform. Industry leaders are investing billions into this field,
including the 2014 purchase of Oculus by Facebook for $2 billion.
VR has been overhyped before, which led to an unfortunate
implosion of interest in the 1990s. The difference now is that
the commodity components from the smartphone industry--
computers, sensors, and displays--have surprisingly enabled
low-cost, wide-field-of-view VR headsets to be mass produced.
The question remains: What is this new medium or platform
good for? Smartphones were once designed to be telephones, but
their success is based on almost everything but making phone
calls. Examples include maintaining social networks (Facebook)
and arranging transportation (Uber). VR is in the early stage that
smart phones were in 15 years ago. The current generation is
targeted at video games, but most transformative uses of VR are
yet to be discovered. While industry leaders use their experience
and power to push in directions that seem like more of the same,
we will also see numerous small teams trying completely new
ideas from scratch. This is where universities and startups can
exert great influence over our future.
RESEARCH: The design of planning algorithms focused
on problems that involve continuous spaces, complicated
geometric constraints, differential constraints, and/or sensing
uncertainties. Such problems are fundamental in areas such
as robotics, computer graphics, architectural design, and
computational biology.
HONORS: } Director, Motion Planning Lab } Principal scientist
at Oculus VR for two years, prior to its aquisition by Facebook.
} Featured in Museum of Science and Industry, Chicago’s Robot
Revolution Exhibit } Editor for IEEE International Conference on
Robotics and Automation, ICRA 2013, 2012, 2011.
14  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Mani
Golparvar-Fard
CIVIL & ENVIRONMENTAL
ENGINEERING
FLYING SUPERINTENDENTS: ACTIONABLE DATA
ANALYTICS FOR CONSTRUCTION PROJECTS VIA
CAMERA-EQUIPPED DRONES AND 3D BUILDING MODELS
ABSTRACT: Early detection of actual or potential performance
deviations in field construction activities is critical to project
management. It provides an opportunity to initiate proactive
actions to avoid delays or minimize their impacts. Despite
their importance, current monitoring practices are tedious and
non-systematic. They also involve qualitative assessments
and visually complex reporting. This talk addresses these
inefficiencies by introducing a new platform that provides
the easiest and quickest access to construction performance
“analytics” via images captured with camera-equipped aerial
robots and 4D (3D+time) building models. The platform offers
an end-to-end data analytics solution, including automated
data capture, processing, and delivery via an online interactive
interface accessible through commodity smartphones and
tablets. Several real-world pilot projects will also be presented
where the platform is providing actionable analytics on a daily
basis to optimize construction workflows.
RESEARCH: Computer vision sensing and analytics for
construction performance monitoring
HONORS: } Faculty Entrepreneurial Fellow from the College of
Engineering, University of Illinois, 2015 } CETI outstanding early
career researcher from FIATECH, 2014 } James R. Croes Medal
from the American Society of Civil Engineers, 2013 } CES2013
Innovation Award from Consumer Electronic Show, 2013
START-UP COMPANIES: CloudPoint Labs: Transforming
planogram auditing, omni-channel retailing, construction
monitoring, and automotive experiences with cloud-based
computer vision. (www.cloudpoint.io)
Sanjay Patel
ELECTRICAL & COMPUTER
ENGINEERING
INVENTING THE FUTURE OF MOBILE IMAGING AT
UNIVERSITY OF ILLINOIS AND PERSONIFY
ABSTRACT: Personify was spun out of the University of Illinois
in 2010 as a company in the 3D imaging space. Since then,
we’ve enjoyed a symbiotic relationship with the University jointly
imagining and developing the future of mobile imaging through
technology, design, and product development. Today, Personify
is in the vanguard of mobile imaging, developing new ways for
people create, broadcast, and share concepts and ideas through
video and images captured on their mobile devices. Working with
the University, we are embarking on a bold vision whereby mobile
devices can be used to capture holographic videos for immersive
displays such as VR headsets.
RESEARCH: Computer architecture, ASIC design, imaging,
computer vision, mobile sensing, and mobile computing
HONORS: } College of Engineering Willett Faculty Scholar,
2002-2009 } IBM Faculty Partnership Award, 2003-2004,
2004-2005
Share the Vision 2015  •  Faculty Presentations  15
Ranjitha
Kumar
COMPUTER SCIENCE
DATA-DRIVEN DESIGN
ABSTRACT: The Web has transformed the nature of creative
work. For the first time, millions of people have a direct outlet
for sharing their creations with the world. As a result, the Web
has become the largest repository of design knowledge in
human history, and the ensuing “democratization of design” has
created a critical feedback loop, engendering a new culture of
reuse and remixing.
The means and methods designers employ to draw on prior
work, however, remain mostly informal and ad hoc. How can
content producers find relevant examples amongst hundreds
of millions of possibilities and leverage existing design practice
to inform and improve their creations? My research explores
data-driven techniques for working with examples at scale during
the design process, automating search and curation, enabling
rapid retargeting, and learning generative probabilistic models to
support new design interactions. Knowledge discovery and data
mining have revolutionized informatics; in this talk, I’ll discuss
what we can learn from mining design.
START-UP COMPANY: Personify: using the most advanced
technologies in computer vision to develop fresh and immersive
video experiences, which can facilitate real and meanginful
connections with everyone, everywhere. (www.personify.com)
RESEARCH: Human-computer interaction, with a Focus on
bringing data mining and machine learning to bear on problems
in design.
HONORS: } ACM CHI Best Paper Award, 2013 } ACM UIST
Best Paper Nomination, 2012 } Google PhD Fellowship in Design
Development, 2011–2013
START-UP COMPANIES: Apropose: a start-up out of Stanford
that is developing an analytics platform helps designers search,
aggregate, and operationalize design data from the millions
of sites on the Web. The company closed a $1.875M seed
funding round co-led by New Enterprise Associates (NEA) an d
Andreesen Horowitz. (www.apropose.com)
DATA-DRONES OF THE SOCIOTECHNICAL SOCIETY
OF FUTURE
ABSTRACT: Technological advances today have the potential
to transform the life of everybody within the next 20-30 years
in a dramatic way. The society of non-distant future assumes
co-existence of humans, pilotless planes, driverless cars, and
robots, in which machines and human beings share the airspace,
the roads, and populate indoor environments. This idea poses
significant challenges, falling within the scope of engineering,
psychology, social science, politics, ethics, and economics.
Naira
Hovakimyan
MECHANICAL SCIENCE
& ENGINEERING
16  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Inspired by this vision, we focus on the development of aerial
co-robots that are required to safely interact with humans in a
shared space and assist humans in a variety of tasks. Potential
applications include building situation awareness for public
safety, precision farming, health care, assisted living, filming,
precision surveying, inspection and many others.
RESEARCH: Robust adaptive control and estimation, networks
of autonomous systems, game theory and applications of those
in safety-critical systems of aerospace, mechanical, electrical,
petroleum, and biomedical engineering.
HONORS: } Grafton and Wilkins Professor of Mechanical
Science & Engineering } Society of Women Engineers
Achievement Award } American Institute of Aeronautics and
Astronautics Mechanics & Control of Flight Award } Humboldt
Prize, 2014
START-UP COMPANY: IntelinAir: developing data-drones for
enhanced situational awareness and real-time decision making
in precision farming, public safety, inspection, forestry, and many
others. The company closed $1.5 million in seed funding from
angel investors in January 2015, and is going for a Series A round
this Fall. (www.intelinair.com)
Share the Vision 2015  •  Faculty Presentations  17
Networked Systems
& Security
Brighten
Godfrey
COMPUTER SCIENCE
BUILDING TRUSTWORTHY NETWORKS WITH
VERIFICATION
ABSTRACT: We rely on network infrastructure to deliver critical
services and ensure security. Yet networks today have reached
a level of complexity that is far beyond our ability to have
confidence in their correct behavior – resulting in significant time
investment and security vulnerabilities that can cost millions of
dollars, or worse. In this talk, I will discuss the emerging field
of network verification, which transforms network security by
rigorously checking that the policy intent of a network engineer is
correctly realized across the live running network. Our research
work developed a technique called data plane verification,
which has discovered problems in operational environments
and can verify policies with millisecond-level latency in dynamic
networks. In just a few years, data plane verification has moved
from early research prototypes to production deployment. I’ll
also discuss the future of network verification in academic
research and industry.
RESEARCH: Design and analysis of networked systems and
algorithms, low latency networked systems, data center network
architectures, software-defined networks, network security and
debugging, and social network analysis algorithms.
HONORS: } Sloan Fellowship, 2014 } National Science
Foundation CAREER Award, 2012 } IEEE Communications
Society & Information Theory Society Joint Paper Award, 2012
START-UP COMPANY: Veriflow Systems: commercializing a
technology that provides a fundamental advance in the ability to
secure online systems. Veriflow Systems is backed by a strong
team of investors, including New Enterprise Associates (NEA),
the National Science Foundation, and the US Department of
Defense. (www.veriflowsystems.com)
18  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Robin Kravets
COMPUTER SCIENCE
THE INTERNET OF THINGS: THE PROMISES AND
THE CHALLENGES
ABSTRACT: Every day, users are interacting with hundreds and
thousands of devices in both intentional and unintentional ways.
Currently, these devices are being linked through local and cloud
services to form an Internet of Things (IoT). As users interact
with this IoT in stores, museums and other public spaces to
find useful localized information, they leave breadcrumbs in the
form of information traces about their presence, preferences
and behavior. By intentionally exposing pieces of their personal
information, users could benefit from complex services and
enhanced interactions. Additionally, organizations, including
retail locations and museums, can provide sophisticated
benefits in exchange for this information. However, to prevent
unintentional leaks of personal information, users must be able
to manage their information exposure. To this end, the users and
organizations need to collaborate through an IoT ecosystem that
benefits both the users and organizations, while allowing the
users to protect their personal information.
RESEARCH: Communication issues in networks that are
challenged by mobility, including wireless LANs, ad hoc
networks, sensor network, delay and disruption tolerant
networks, vehicular networks, mobile social networks and
personal area networks with a focus on solutions that enable
effective power management, connectivity management, data
transport, congestion management, location management,
routing and security.
Klara
Nahrstedt
COMPUTER SCIENCE
IMPACT OF ELECTRIC VEHICLES ON PHYSICAL AND
DIGITAL POWER-GRID INFRASTRUCTURE
ABSTRACT: With the rapid increase of electric vehicles in many
urban areas, this type of transport has a major impact on the
physical infrastructure and on the cyberinfrastructure of our
power grid. We will discuss the impact of electric vehicles on (a)
road electrification via static and dynamic wireless charging as
part of the physical power grid infrastructure and (b) real-time
security for V2G (Vehicle-to-Grid) communication as part of the
digital power grid infrastructure.
RESEARCH: : Multimedia systems, wireless and wired
networks, scheduling, QoS routing, resource management for
distributed multimedia systems, 3D tele-immersive systems,
and trustworthy cyber-physical systems. Professor Nahrstedt is
a leading researcher in multimedia systems and networks. Her
fundamental work on QoS routing, energy-efficient dynamic
soft-real-time CPU scheduling for mobile multimedia devices
(GRACE-OS), and multi-view 3D video distribution algorithms
(View-Cast, 4D-Telecast) has been widely recognized in
academia and industry.
HONORS: } Director, Coordinated Science Laboratory } Chair,
ACM SIG Multimedia, 2007-2013 } $10,000,000 NSF Frontier
Award for Trustworthy Health and Wellness (THaW), 2013
Share the Vision 2015  •  Faculty Presentations  19
Gul Agha
COMPUTER SCIENCE
BUILDING SMART INFRASTRUCTURE FOR SMART CITIES
ABSTRACT: Over the past 15 years, we have developed
software, hardware and networking technology to support
sensing as a service for the Internet of Things. We have applied
our technology to provide civil infrastructure monitoring
solutions. Sensing at multiple scales, we can assess structural
conditions in real-time. Such assessments will rationalize
maintenance as well as provide situation awareness after
extreme events such as earthquakes and hurricanes. Our pilot
smart sensor network deployment on bridges demonstrates an
attractive value proposition for developing smart cities: providing
infrastructure monitoring capabilities to increase efficiency while
improving public safety.
RESEARCH: Mechanisms to simplify the development of
scalable parallel, distributed and mobile computing systems.
Developing concurrent programming languages and systems
which support applications with high-performance, fault-
tolerance or real-time requirements.
HONORS: } Fellow of the Institute of Electrical and Electronics
Engineers (IEEE) } Former Editor-in-Chief of ACM Computer
Surveys and of IEEE Parallel and Distributed Technologies
} IEEE Computer Society Meritorious Service Award.
START-UP COMPANY: Embedor Technologies: monitoring the
structural health of civil infrastructure using wireless networked
sensors that are capable of sensing at multiple scales to facilitate
reliable, real-time structural condition assessment for extreme
events and long-term deterioration. (www.embedortech.com)
HONORS: } Co-chair, ACM MobiCom,
2013 } MobileFirst Google Focused Research
Grant } Google Open Web Things Expedition
20  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Poster Sessions
Share the Vision 2015  •  Poster Sessions  21
Actif
ALEX LEE
Actif provides wearable technology to promote the
active lifestyle. Our system allows the user to effectively
communicate with others sharing the road. The technology
is integrated into premium build materials to give the user a
seamless experience.
AxoBot
KUNHYUCK LEE
AxoBot is developing a pre-fabricated orthosis to help any
class of patients with physical disabilities to benefit from the
low-cost customizable prosthesis by mass-producing the
modulated actuators programmed with optimized “body-
movement-algorithm.”
Chairdrop
DAVID KIRBY
Chairdrop aims to streamline the traveling experience of people
with disabilities by enabling travelers to rent wheelchairs and
other medical equipment at their destination, rather than pack
and travel with their own.
Corvae
RYAN BROWN
Corvae has created a portable and wireless electrocardiograph
monitor with real-time analytics and an intuitive interface. Both
raw and processed data are made available wirelessly on web
and mobile platforms. The Corvae heart monitoring platform will
enable firefighters, nurses, and outpatients peace of mind and
efficient data analysis. Corvae aims to provide intuitive displays,
wireless connectivity, and real time analytics to customers in need.
Cretmo Labs
ADAM BURNS
42 million manual wheelchair users worldwide, face shoulder
injury due to repeated pushing. I3 is a revolutionary and
affordable wearable technology that tracks shoulder usage to
minimize injury and improve quality of life.
Electricity Demand Forecasting
SPENCER GUERRERO
Campus load is determined by many high electricity consumptive
buildings, including labs, dormitories, office buildings, a chilled
water plant and the Blue Waters supercomputer. Combining
advanced statistical techniques this team has developed and
deployed an algorithm that forecasts hourly campus load for the
next 5 days. Back tests suggest possible savings for the Urbana
campus of 20% on electricity hedging costs.
22  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Invoq Health
MAYANK KALE
Invoq Health builds intuitive and scalable mobile technologies
for community health organizations. The software can be used
to collect, store, transfer and analyze health data on the field.
It empowers organizations to maintain a complete database
of their patients and deliver effective health services at
point-of-care.
LAIT
JOHN TOENJES AND TONY REIMER
LAIT is a mobile app platform that theatrical producers use to
deliver content to audience members instantly, on cue, through
their phones. LAIT also can gather audience responses, making
each show a two-way interactive experience.
Malleable and Processable
Thermoset Based on Dynamic
Polyurea
HANZE YING
This team has developed a new type of thermosets materials
based on dynamic polyurea. While keeping the advantages of
conventional thermosets including high mechanical strength and
solvent resistance, the new materials also show new properties
of processability and recyclability induced by the feature of
reversible urea bond.
Psyonic
AADEEL AKHTAR
Psyonic develops highly advanced prosthetic hands at 10x less
cost to improve the lives of people with amputations worldwide.
MetroFlow
NILS OBERG AND BLAKE LANDRY
MetroFlow develops software tools for modeling the water
quality of highly-urbanized areas with combined sewer systems.
The Mouve
MARCO FABREGA
The Mouve allows you to create, share, and discover events with
your friends and to the masses, while getting real-time footage to
give you a sneak peak of what to expect.
Share the Vision 2015  •  Poster Sessions  23
Trigger-Induced Activation of
Caged Metabolic Precursor
for Selective Cell Labeling and
Cancer Targeting
HUA WANG
This team has developed a controlled labeling strategy to label
cell types of interest with chemical groups. This controlled
labeling strategy, coupled with various efficient Click chemistries,
can be used for precise diagnosis and treatment of diseases,
especially cancers.
Your New Scope
JIMMY NI
Your New Scope produces a wearable treatment kit that makes
psoriasis treatment at home easy, especially for severe cases.The
product allows treatment to be monitored and adjusted in real
time through app/device seamlessly by doctors.
24  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Start-Up Presentations
SHOWN IN ORDER OF PRESENTATION
Share the Vision 2015  •  Start-Up Presentations  25
PhotoniCare
RYAN SHELTON, PHOTONICAREINC.COM
Developing handheld imaging tools to revolutionize the
management of middle ear infections, the leading cause
of hearing loss and surgeries in children. PhotoniCare’s
CLEARVIEW device improves outcomes and reduces healthcare
costs, making it a win-win for everyone. Clinical studies using the
device are underway at multiple locations across the U.S. The
company has raised nearly $2M in non-dilutive capital in 2015
from multiple sources. } Champaign, IL
BioNanoCon
ABHINAV LUTHRA, BIONANOCON.COM
Advancing the progress of membrane protein drug development
through Nanodisc technology. Nanodiscs are nanoscale
membrane bilayer patches encircled by an amphipathic
alpha-helical protein called the membrane scaffold protein.
By providing a native-like environment to the membrane
protein target, Nanodiscs offer enhanced stability while being
homogenous and monodisperse. } Urbana, IL
Electrocyt
BOBBY REDDY, ELECTROCYT.COM
Porting the power of the traditional diagnostic labs to the comfort
and convenience of local testing centers and patient’s homes
with novel devices such as LifeCounts, the world’s first handheld
Complete Blood Count diagnostic platform.} Champaign, IL
Neurolux
TONY BANKS
Providing ultra-miniaturized wireless neural implant devices to
the neuroscience community. Ultrathin, flexible optofluidic neural
probes enable wireless delivery of agents and optical manipulation
in deep brain tissue of freely behaving animals. Combinatorial
optogenetic, pharmacological, and viral approaches yield a powerful
tool for in vivo dissection of neural circuitry. } Champaign, IL
Start-Ups in
Healthcare
26  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Phi Optics
CATALIN CHIRITESCU, PHIOPTICS.COM
Developing optical imaging systems through its Quantitative
Phase Imaging platfom. Phi Optic’s product is an electro-optic
device that attaches to new and existing research grade optical
microscopes and provides faster and more accurate imaging of
live cells and tissues than currently possible with the state-of-
the-art technology. } Champaign, IL
IntelliWheels
SCOTT DAIGLE, INTELLIWHEELS.NET
Developing technology to improve mobility options for
wheelchair users, including handrim grips, easy-push gears, and
wheels designed to reduce stress on shoulders. } Champaign, IL
Glucosentient
TIAN LAN, GLUCOSENTIENT.COM
Developing technology that is transforming the personal
glucose meter into a device that is capable of quantitatively and
conveniently detecting non-glucose targets. The technology
translates the amount of non-glucose target to glucose, which
is then measured by the PGM. The technology is robust and
widely applicable, including heavy metal ions (environmental
monitoring), small molecules (drug monitoring, drugs-of-abuse
tests), protein markers (immunoassay diagnostics) and nucleic
acid (molecular diagnostics) quantification. } Champaign, IL
Exalt Diagnostics
BRIAN CUNNINGHAM, EXALTDIAGNOSTICS.COM
Imagine having a machine that can perform nearly any biological
diagnostic test, including identifying an infectious disease,
monitoring for the presence of biomarkers for cancer and
heart disease, performing daily viral load tests, checking the
authenticity of medications, and detecting allergens in food
– and that your machine will instantly share results with your
physician and networks of clinicians who use the information to
rapidly spot trends that improve the effectiveness of healthcare
in entire communities. You, and everyone you know, already
owns this machine: It’s your smartphone. Exalt Diagnostics
was established to commercialize patented technology from the
research group of Prof. Brian Cunningham at the University of
Illinois at Urbana-Champaign that enables the internal camera
of any mobile device to function as a high-sensitivity and
high-resolution instrument for point-of-care diagnostics. The
company is leveraging NSF-funded research that has resulted
in working prototype systems that have been demonstrated for
several representative applications with high market potential.
} Champaign, IL
Aptimmune Biologics
FEDERICO ZUCKERMANN, APTIMMUNE.COM
Aptimmune is developing mucosal vaccines for viral diseases
of swine with a focus on porcine reproductive and respiratory
syndrome (PRRS) and influenza. Aptimmune’s formulations
utilize patented revolutionary technologies. The first product will
launch in 2016.} Champaign, IL
Share the Vision 2015  •  Start-Up Presentations  27
BioAnalytics
MICHAEL WILLARD, BIOANALYTICSYSTEMS.COM
BioAnalytics is a biotechnology company developing next
generation tools for protein analysis. Using a proprietary
chemical method of modifying existing antibodies, BioAnalytics
is able to amplify antibody binding strength by over 100X.
BioAnalytics uses this technique in conjunction with a broadly
applicable method of reducing immunoassay complexity and
cross reactivity to provide tests with half the number of steps, 2X
faster turnaround times, 100X higher sensitivity, 37X improved
specificity, and 390X reduced cross reactivity in multiplexed
applications. BioAnalytics is currently focused on developing
tests for use in academic research and pharmaceutical
development, but ultimately plans to apply their technology to
point-of-care medical diagnostics. } Champaign, IL
28  University of Illinois at Urbana-Champaign  •  The Office of Technology Management
Start-Ups in
Engineering/IT
Voxel8
JENNIFER LEWIS, VOXEL8.CO
Providing new functional materials, such as thermoplastics and
highly conductive silver ink, with a 3D printing platform to create
customized electronic devices like quadcopters, electromagnets,
and functional 3D electromechanical assemblies. The company
recently announced $12 million in Series A financing; they have
been named “one of the 50 smartest companies of 2015” by the
MIT Technology Review and “one of the 9 best ideas from CES
2015” by Fast Company. } Somerville, MA
FreeSkies
JAY MULAKALA, FREESKIES.ORG
FreeSkies envisions a world where aerial data collection is simple
and accessible to everyone through the development of autono-
mous software for drones. Our flagship software, the FreeSkies
CoPilot, is the best way to capture aerial videos and photos with
ease. You don’t need to be an expert drone pilot to capture excit-
ing visuals. } San Francisco, CA
OceanComm
ANDY SINGER AND THOMAS RIEDL, OCEANCOMM.CO
Developing a high-speed wireless underwater modem which
enables wireless video streaming underwater and wireless remote
control of underwater vehicles. Currently, the oil and gas industry
heavily relies on remotely operated vehicles (ROVs) to find and
produce resources offshore. These vehicles are all tethered today,
which results in significant operational costs. A wireless solution
could eliminate the costs of having to tether an ROV.
} Champaign, IL
Embedor Technologies
GUL AGHA, EMBEDORTECH.COM
Embedor Technologies is creating solutions for monitoring the
structural health of civil infrastructure using wireless networked
sensors. Embedor’s smart sensor platform and software
framework are capable of sensing at multiple scales to facilitate
reliable, real-time structural condition assessment for extreme
events and long-term deterioration. } Champaign, IL
Share the Vision 2015  •  Start-Up Presentations  29
FlipWord
THOMAS REESE, GETFLIPWORD.COM
Developing a browser application that switches a few words
on every webpage to the user’s desired language, so he or she
can learn a new language passively. FlipWord is the winner of
the 2015 Cozad New Venture business plan competition at the
University of Illinois. } Champaign, IL
AE Machines
ERIC MINNICK, AEMACHINES.COM
Building tools to allow people to design and automate machine
movement thereby allowing businesses to implement simple
automation in their processes and realize the cost and efficiency
gains that accompany such implementation. Initially, AE
Machines will be a web-based software provider, allowing
non-technical users to design and program simple machines via
an intuitive user interface. } Champaign, IL
Agrible
CHRISTOPHER M. HARBOURT, AGRIBLE.COM
Agrible creates analytic tools for farmers and agriculture
companies that provide field-specific data and forecasts to help
with decision-making in the field. Each morning, the company’s
flagship product, Morning Farm Report, provides growers with
information on yields, fieldwork logistics, rainfall, and more,
specific to their fields. This enables them to make the best
decisions based on the best agronomic data available. Agrible
won the 2015 Innovation Celebration Entrepreneurial Excellence:
New Venture Award. } Champaign, IL
Wearifi
TONY BANKS
Providing the world’s thinnest, smallest, most flexible, and
most lightweight near-field communication wearable device
technology. } Champaign, IL
Network Perception
BILL SANDERS AND ROBIN BERTHIER,
NETWORK-PERCEPTION.COM
Developing and launching firewall analysis technology for
critical infrastructures. Network Perception’s software solutions
automatically audit the security and compliance of critical
networks by analyzing the configurations of firewalls and routers.
} Champaign, IL
Harmonia
RICK TAUBE, ILLIACSOFTWARE.COM
Building music technologies for the 21st century. Harmonia
software provides realtime music analysis, automatic grading,
and course analytics. Harmonia was awarded a $225,000 STTR
Phase I grant in 2014. } Champaign, IL
Office of Technology Management
University of Illinois at Urbana-Champaign, Ceramics Building, Suite 319, 105 S. Goodwin Avenue, Urbana, IL 61801
217.333.7862  •  otm@illinois.edu  •  otm.illinois.edu  •  Twitter: @ILinnovations
Research Park and EnterpriseWorks
University of Illinois at Urbana-Champaign, 60 Hazelwood Drive, Champaign, IL 61820
217.333.8324  •  researchpark.illinois.edu  •  Twitter: @UIResearchPark
AGRICULTURE & VETERINARY MEDICINE
Brad Edwards, Technology Manager
217.244.6453  •  ebedward@illinois.edu
COMPUTER SCIENCE
Svetlana Vranic-Sowers, Senior Technology Manager
217.244.7243  •  svsowers@illinois.edu
LIFE SCIENCES
Lisa Dhar, Senior Associate Director
217.333.3715  •  ldhar10@illinois.edu
RK Narayanan, Ph.D., Associate Technology Manager
217.300.1614  •  rkn@illinois.edu
ENGINEERING
Nathan Hoffmann, Assistant Director
217.244.4747  •  nhoffma2@illinois.edu
Jeffrey Wallace, Senior Technology Manager
217-265-0548  •  jrwallac@illinois.edu
Steven Wille, Associate Director
217.244.5956  •  stvwille@illinois.edu
ARTS, EDUCATION, SOCIAL SCIENCES & HUMANITIES
Steven Wille, Associate Director
217.244.5956  •  stvwille@illinois.edu
DIRECTOR
Laura Frerichs  •  217.333.8323  •  lfrerich@illinois.edu
DIRECTOR
Lesley Millar-Nicholson  •  217.333.6807  •  millar@illinois.edu
PORTFOLIO MANAGEMENT BY AREA
ASSOCIATE DIRECTOR
Laura Bleill  •  217.244.7744  •  lwbleill@illinois.edu
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  • 1. Share the Vision 2015  •    1 PROGRAM OF EVENTS OCTOBER 8, 2015 UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN INNOVATION & START-UP SHOWCASE
  • 3. Program of Events FACULTY PRESENTATIONS 04 POSTER SESSION 20 START-UP PRESENTIONS 24 SHARE THE VISION  ·  OCTOBER 8, 2015 University of Illinois at Urbana-Champaign Innovation & Start-Up Showcase Hosted by the Office of Technology Management and the University of Illinois Research Park
  • 4. 4  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Faculty Presenters SHOWN IN ORDER OF PRESENTATION
  • 5. Share the Vision 2015  •  Faculty Presentations  5 Martin Burke CHEMISTRY A BILLION YEAR HEAD START ABSTRACT: Natural products represent a billion year head start in the process of discovering new medicines, and most of this potential remains untapped. The problem is that the process of making such complex molecules and their derivatives is difficult and slow, and this bottleneck precludes practical access to the full range of this untapped functional potential. REVOLUTION Medicines has exclusively licensed from UIUC an automated building block-based synthesis platform initially developed in my lab that for the first time enables practical, generalized access to complex natural products and their derivatives for medicinal chemistry. The company is now advancing and harnessing its REVBLOCKS platform to redesign evolution’s products into new medicines for treating serious human diseases. RESEARCH: Development of molecular prosthetics as a general strategy for the understanding and improvement of human health where small molecules with the capacity to perform protein-like functions can serve as substitutes for missing or dysfunctional proteins. HONORS: } Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis by a Young Investigator, 2013 } Arthur C. Cope Scholar Award, American Chemical Society (ACS), 2011 } Howard Hughes Medical Institute Early Career Scientist, 2009 START-UP COMPANY: REVOLUTION Medicines: developing new therapies through an innovative approach that reconfigures natural substances into best-in-class medicines. The company launched in 2015 with a $45 million investment from Third Rock Ventures. (www.revolutionmedicines.com) LICENSES: Professor Burke’s MIDA boronates, which enable diverse arrays of small molecules to be generated simply and quickly by repeatedly using a single reaction to join different organic sub-units, have been licensed to Sigma Aldrich, BoroPharm, and Ally Chem. More than 130 MIDA boronates are now commercially available and these building blocks are being widely utilized to promote the discovery of new medicines by more than 70 pharmaceutical companies around the world. Healthcare: Therapeutics
  • 6. 6  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Jianjun Cheng MATERIALS SCIENCE & ENGINEERING SELECTIVE CELL LABELING AND CANCER TARGETING ABSTRACT: Cell surface protein receptors play a vital role in regulating the interaction between cells and the extracellular environment, especially the influx and efflux of materials including therapeutic agents. The differentiation of cell surface protein receptors between normal and diseased cells will potentially enable targeted delivery of therapeutic agents into the diseased cells and thus minimize undesired side effects. However, the difference in the population of existing receptors between diseased and normal cells in one individual is either too small to impart good high selectivity or highly specific to certain cell types. Our group recently developed a controlled labeling strategy to label cell types of interest with chemical groups by using chemically modified metabolic sugar precursors. This controlled labeling strategy, coupled with various efficient Click chemistries, can be used for diagnosis and treatment of diseases, especially cancers. My presentation will cover basic chemistry design and demonstration of the controlled labeling strategy and its key properties and applications in cancer-targeted treatment. RESEARCH: Developing functional molecular, polymeric and nano-materials and exploring their applications in nanomedicine for drug/gene delivery, imaging and diagnosis HONORS: } Fellow, American Institute for Medical & Biological Engineering (AIMBE), 2015 } Fellow, ACS-POLY, 2015 } NIH Director’s New Innovator Award, 2010 Paul Hergenrother CHEMISTRY, CARLE WOESE INSTITUTE FOR GENOMIC BIOLOGY TRAVERSING THE VALLEY OF DEATH IN ANTICANCER DRUG DISCOVERY ABSTRACT: Anticancer drug discovery is typically a lengthy, expensive, and high-risk enterprise. Statistics show that even after multiple years and millions of dollars, only 5% of candidates that enter a Phase I trial in oncology gain FDA approval. We have pioneered a strategy that enables us to more intelligently choose drug candidates in a rapid and cost-effective manner. In this strategy we evaluate drug candidates in pet dogs with cancer, offering hope for these veterinary cancer patients and their owners, and allowing us to optimize treatment parameters in real cancer patients with heterogeneous tumor populations, metastatic disease, etc. A case study for this strategy will be presented, the discovery and development of the anticancer drug PAC-1. PAC-1 selectively induces cancer cell death though a novel mechanism, activation of procaspase-3. The dosing, timing, and formulation of PAC-1 was optimized through its evaluation in canine cancer patients; over 50 dogs with cancer have been treated with PAC-1 and its derivatives, and PAC-1 shows considerable promise in some of the most difficult-to-treat canine cancers. Largely on the basis of this dog data, the FDA approved our Investigational New Drug application and PAC-1 is now being taken by human cancer patients as part of a Phase I clinical trial at the University of Illinois Cancer Center in Chicago, and at Johns Hopkins University. For more information please see the listing on clinicaltrials.gov: https://clinicaltrials.gov/ct2/show/ NCT02355535
  • 7. Share the Vision 2015  •  Faculty Presentations  7 RESEARCH: Using organic compounds to identify novel cellular targets that can be exploited in the treatment of diseases including cancer and drug-resistant bacteria. HONORS: } Kenneth L. Rinehart Jr. Endowed Chair in Natural Products Chemistry } Eli Lilly Award in Biological Chemistry, 2008 START-UP COMPANIES: Vanquish Oncology: developing procaspase-3 activating compounds, known as PAC-1, as a cancer therapeutic. The compound is now in Phase I clinical trials. (www.vanquishoncology.com) Douglas Mitchell CHEMISTRY, CARLE WOESE INSTITUTE FOR GENOMIC BIOLOGY GENOMICS-ENABLED NATURAL PRODUCT DISCOVERY ABSTRACT: Natural products have been, without question, the most prolific source of all medicines, especially antibiotics. Genome sequencing has revealed that our knowledge of natural product structure and function is astonishingly incomplete. Therefore, exploration of uncharted natural product chemical space will undoubtedly lead to improved, and entirely new, medicines. Against this backdrop, our group focuses on elucidating the biosynthesis, structure, and function of natural products. This talk will highlight our recent advances in genomics- enabled natural product discovery while covering a few case studies in enzymatic biosynthesis that could be exploited to introduce new drug leads. RESEARCH: Identifying and characterizing novel antibiotic compounds through genome-mining, isolation and characterization of novel natural products, and mechanistic studies of key natural product biosynthetic enzymes. HONORS: } Pfizer Award in Enzyme Chemistry (ACS Division of Biological Chemistry), 2015 } National Fresenius Award, Phi Lambda Upsilon (National Chemistry Honor Society), 2015 } NIH Director’s New Innovator Award, 2011 } Packard Fellowship, 2012 David Kranz BIOCHEMISTRY A NEW GENERATION OF CANCER THERAPEUTICS: T CELLS AND T CELL RECEPTORS ABSTRACT: In the past two years there has been a large investment (billions$) by venture firms and pharmaceutical companies in the area known as adoptive cell therapies (ACT). The goal of this new generation of cancer therapeutics is to destroy tumors with very specific and potent agents, a patient’s own T cells (i.e. one of the key types of white blood cells). The investment in this strategy has been based on exciting, and widely publicized, early clinical results. However, there remain many questions about how the approach will be more broadly applied to millions of patients. One avenue that our lab has focused on over the past twenty years has been to engineer improvements in the key molecule involved in the specific-cancer targeting activity of T cells, the T cell receptor. Our lab’s work
  • 8. 8  University of Illinois at Urbana-Champaign  •  The Office of Technology Management has identified some of the parameters involved in improving both protein- and cell-based therapeutics in this class of agents. The technologies developed around these studies formed the basis of two University of Illinois start-up companies, BioDisplay and ImmuVen, which were acquired by pharmaceutical companies. This presentation will discuss the science behind this work, and its potential application toward helping cancer patients with more efficacious treatments that have significantly reduced side effects (e.g. compared to chemo). RESEARCH: Understanding a fundamental issue in immunology: how mammals can eliminate millions of different antigens that are “foreign” (e.g. viruses, bacteria) without destroying antigens that are “self” (e.g. one’s own tissues). The specific focus of the lab is on the antigen-specific receptor expressed by T lymphocytes (T cell receptor, TCR). HONORS: } Phillip A. Sharp Professor of Biochemistry START-UP COMPANY: BioDisplay: Developed yeast-display methodology using flow cytometry to provide high-throughput screening, which in turn speeds the process of directed drug discovery. Immuven: developing new biotherapeutics to treat cancer, infectious disease, and autoimmune disorders. The platform allows rapid selection and optimization of T cell receptors with high affinity to targets in cancer, infections, and autoimmune pathways.
  • 9. Share the Vision 2015  •  Faculty Presentations  9 Healthcare: Medical Devices John Rogers MATERIALS SCIENCE & ENGINEERING MILLIMETER-SCALE WIRELESS WEARABLES ABSTRACT: Advanced concepts in antenna design, hybrid materials, computing platforms and energy harvesters form the technology foundations for the world’s smallest wireless sensors. This talk demonstrates these ideas through a family of wearable systems configured to mount on the fingernails, for robust operation over months of continuous use, without removal, during normal daily activities. Application opportunities range from authentication, hardware security and data transactions, to personal health monitoring and UV sensing. Joint development activities with two large corporate partners will be highlighted. RESEARCH: Electronic materials for devices that have unusual properties, including those that match the soft, curvilinear surfaces of biological tissues. Applications in wearables, advanced surgical tools, and other biomedical systems. HONORS: } Elected to the National Academy of Sciences, 2015 } Smithsonian Award for American Ingenuity in the Physical Sciences, 2013 } $500,000 Lemelson Prize, 2011 }MacArthur Fellowship, 2009 START-UP COMPANIES: mc10: commercializing classes of electronics that can fold, twist, and conform to three dimensional surfaces. Applications range from wearable sports monitors to advanced surgical tools, to disease management and others. (www.mc10.com) Semprius: commercializing low cost, high performance concentrator photovoltaic modules for utility scale power generation. The company’s unique mirco-transfer printing technology enables CPV modules with world-record efficiencies. (www.semprius.com) X-celeprint: commercializing a cost-effective and scalable manufacturing platform based on micro-transfer printing for integrating micro-scale devices such as lasers, LEDs, or integrated circuits onto non-native substrates. (www.x-celeprint.com) Wearifi: creating the world’s thinnest, smallest, most flexible, and most lightweight near-field communication wearable device technology.
  • 10. 10  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Curtis Johnson BECKMAN INSTITUTE FOR ADVANCED SCIENCE & TECHNOLOGY MECHANICAL IMAGING OF THE HUMAN BRAIN ABSTRACT: Medical diagnostics have a long history of utilizing the mechanical properties of tissues to identify the presence of pathology through manual palpation. Our group harnesses the inherent mechanical contrast in disease to noninvasively characterize brain tissue through an imaging method called magnetic resonance elastography. Pathology can result in tissue stiffness and viscosity changes by an order of magnitude relative to healthy tissue, thus making tissue mechanical properties potentially very sensitive markers of tissue health. This talk will discuss our development of the high-resolution brain elastography method for applications in neurology and neurosurgery in partnership with the Carle Foundation Hospital. In particular, we will highlight the work in pre-surgical evaluation of intracranial tumors and the medial temporal lobe in epilepsy. RESEARCH: The development of novel imaging methods for characterizing the structure, function, and health of tissue, particularly interested the use of tissue mechanics for applications in neurosurgery, neurology, and neuroscience. HONORS: } Junior Fellow of the International Society for Magnetic Resonance in Medicine } BRAIN Grand Challenges Young Investigator Award, 2014 Paul Braun MATERIALS SCIENCE & ENGINEERING, BECKMAN INSTITUTE FOR ADVANCED SCIENCE & TECHNOLOGY SENSOR MATERIALS FOR IN VIVO EXTENDED CONTINUOUS GLUCOSE MONITORING ABSTRACT: Diabetes is a worldwide epidemic, and as such, extensive research efforts towards glucose measurement technologies have been maintained for the last 3 decades. Although continuous glucose monitoring (CGM) has garnered considerable attention due to the advantages in maintaining tight glycemic control, successes in continuous monitoring have been limited, and thus today, most glucose monitoring is still performed using single use test strips. CGM requires sensors with high precision, accuracy, sensitivity and stability, and if possible, a linear response, characteristics that prior to our developments have not been demonstrated in a sensor material. We have now developed a new class of hydrogels that volumetrically respond to glucose with the aforementioned features. A photonic crystal is incorporated into such glucose responsive hydrogel matrix as a signal transducer to convert the hydrogel volume change into diffracted wavelength shift which is recorded by a spectrometer, although other readout modalities are also possible. The sensor materials meet key CGM requirements in physiological buffer solutions and serum at body temperature. Furthermore, miniaturized devices suitable for in vivo blood glucose monitoring can be formed using such sensor materials.
  • 11. Share the Vision 2015  •  Faculty Presentations  11 RESEARCH: The formation and study of nano and microstructured materials through self and directed assembly. The Braun group uses and develops new materials chemistry approaches to the synthesis of these materials, which enables realization of novel form factors of matter with advanced functionalities. HONORS: } Friedrich Wilhelm Bessel Research Award, 2010 } Defense Science Study Group, 2010-2011 START-UP COMPANIES: Autonomic Materials: self-healing technologies that extend coating lifetimes, minimizing upkeep and repair. (www.autonomicmaterials.com) Xerion Advanced Battery: developing next-generation ultra-high power, high energy lithium ion batteries using scalable manufacturing methods. (www.xerionbattery.com) Stephen Boppart ELECTRICAL & COMPUTER ENGINEERING, BIO- ENGINEERING, BECKMAN INSTITUTE FOR ADVANCED SCIENCE & TECHNOLOGY LABEL-FREE MULTIMODAL MULTIPHOTON IMAGING FOR MOLECULAR HISTOPATHOLOGY ABSTRACT: Multiphoton imaging provides three-dimensional high-resolution imaging, and has been established as a powerful technology in biomedicine. The most attractive aspect of multiphoton imaging is the wealth of molecular contrast that can be generated from various modalities. Coherent anti- Stokes Raman/stimulated Raman scattering (CARS/SRS) probes molecular vibrations, two-/three-photon fluorescence (2PF/3PF) visualizes intrinsic fluorophores, and second/third harmonic generation (SHG/THG) maps non-centrosymmetirc media and heterogeneity. Integrating multiple modalities enables label-free imaging of complementary endogenous biomolecules, and is therefore highly desirable for biomedical diagnostics. However, integration and further clinical translation of these techniques are not trivial due to the complexity of the laser(s) and the imaging system, and the compromises that are often made for multiple modalities. We have developed a solution that uses a compact ultrafast source to replace bulky lasers, and a pulse processing device to arbitrarily tailor the illumination pulses for multiple modalities. We demonstrate an integrated multimodal multiphoton imaging platform using fiber supercontinuum and pulse shaping. The high-quality fiber supercontinuum is generated in a highly nonlinear all-normal- dispersion fiber, achieving a spectrum spanning the optical biological window with high coherence, high power, and long- term stability. Adaptive pulse shaping of the supercontinuum pulses enables high-performance CARS/2PF/SHG/3PF/ THG imaging of normal/cancerous human breast tissue, as well as the longitudinal molecular/structural changes during mammary tumor formation in a carcinogen-induced rat tumor model. This multimodal multiphoton imaging platform offers improved simplicity and expanded versatility, and the results show a promising path for the translation and commercialization of multiphoton imaging for molecular histopathology and intraoperative surgical applications. RESEARCH: Using light to image biological tissue and diagnose disease. Using advanced imaging techniques such as optical coherence tomography (OCT), nonlinear interferometric vibrational imaging (NIVI), interferometric synthetic aperture microscopy (ISAM), and multi-photon microscopy, it is feasible to generate high-resolution, real-time, non-invasive images of biological tissue at the cellular and molecular level for diagnosing diseases such as cancer.
  • 12. 12  University of Illinois at Urbana-Champaign  •  The Office of Technology Management HONORS: } Abel Bliss Professor of Engineering } MIT Technology Review’s Top 100 Young Innovators in the World, } International Han Sigrist Prize in Laser Medicine, } Fellow of AAAS, IEEE, OSA, SPIE, AIMBE START-UP COMPANIES: Photonicare: developing a handheld imaging tool that enables physicians to quickly and accurately diagnose middle ear infections during routine examinations. (www.photonicareinc.com) DiagnosticPhotonics: placing a live view of tissue microstructure at the physician’s fingertips, providing immediate insight that enables more informed decisions and better care. (www.diagnosticphotonics.com)
  • 13. Share the Vision 2015  •  Faculty Presentations  13 Robotics & Computer Vision Steven LaValle COMPUTER SCIENCE VIRTUAL REALITY: WHAT’S IT GOOD FOR? ABSTRACT: That is for you to figure out! You may have seen articles appearing everywhere these days on virtual reality (VR) technology and how it is poised to become the next great medium or platform. Industry leaders are investing billions into this field, including the 2014 purchase of Oculus by Facebook for $2 billion. VR has been overhyped before, which led to an unfortunate implosion of interest in the 1990s. The difference now is that the commodity components from the smartphone industry-- computers, sensors, and displays--have surprisingly enabled low-cost, wide-field-of-view VR headsets to be mass produced. The question remains: What is this new medium or platform good for? Smartphones were once designed to be telephones, but their success is based on almost everything but making phone calls. Examples include maintaining social networks (Facebook) and arranging transportation (Uber). VR is in the early stage that smart phones were in 15 years ago. The current generation is targeted at video games, but most transformative uses of VR are yet to be discovered. While industry leaders use their experience and power to push in directions that seem like more of the same, we will also see numerous small teams trying completely new ideas from scratch. This is where universities and startups can exert great influence over our future. RESEARCH: The design of planning algorithms focused on problems that involve continuous spaces, complicated geometric constraints, differential constraints, and/or sensing uncertainties. Such problems are fundamental in areas such as robotics, computer graphics, architectural design, and computational biology. HONORS: } Director, Motion Planning Lab } Principal scientist at Oculus VR for two years, prior to its aquisition by Facebook. } Featured in Museum of Science and Industry, Chicago’s Robot Revolution Exhibit } Editor for IEEE International Conference on Robotics and Automation, ICRA 2013, 2012, 2011.
  • 14. 14  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Mani Golparvar-Fard CIVIL & ENVIRONMENTAL ENGINEERING FLYING SUPERINTENDENTS: ACTIONABLE DATA ANALYTICS FOR CONSTRUCTION PROJECTS VIA CAMERA-EQUIPPED DRONES AND 3D BUILDING MODELS ABSTRACT: Early detection of actual or potential performance deviations in field construction activities is critical to project management. It provides an opportunity to initiate proactive actions to avoid delays or minimize their impacts. Despite their importance, current monitoring practices are tedious and non-systematic. They also involve qualitative assessments and visually complex reporting. This talk addresses these inefficiencies by introducing a new platform that provides the easiest and quickest access to construction performance “analytics” via images captured with camera-equipped aerial robots and 4D (3D+time) building models. The platform offers an end-to-end data analytics solution, including automated data capture, processing, and delivery via an online interactive interface accessible through commodity smartphones and tablets. Several real-world pilot projects will also be presented where the platform is providing actionable analytics on a daily basis to optimize construction workflows. RESEARCH: Computer vision sensing and analytics for construction performance monitoring HONORS: } Faculty Entrepreneurial Fellow from the College of Engineering, University of Illinois, 2015 } CETI outstanding early career researcher from FIATECH, 2014 } James R. Croes Medal from the American Society of Civil Engineers, 2013 } CES2013 Innovation Award from Consumer Electronic Show, 2013 START-UP COMPANIES: CloudPoint Labs: Transforming planogram auditing, omni-channel retailing, construction monitoring, and automotive experiences with cloud-based computer vision. (www.cloudpoint.io) Sanjay Patel ELECTRICAL & COMPUTER ENGINEERING INVENTING THE FUTURE OF MOBILE IMAGING AT UNIVERSITY OF ILLINOIS AND PERSONIFY ABSTRACT: Personify was spun out of the University of Illinois in 2010 as a company in the 3D imaging space. Since then, we’ve enjoyed a symbiotic relationship with the University jointly imagining and developing the future of mobile imaging through technology, design, and product development. Today, Personify is in the vanguard of mobile imaging, developing new ways for people create, broadcast, and share concepts and ideas through video and images captured on their mobile devices. Working with the University, we are embarking on a bold vision whereby mobile devices can be used to capture holographic videos for immersive displays such as VR headsets. RESEARCH: Computer architecture, ASIC design, imaging, computer vision, mobile sensing, and mobile computing HONORS: } College of Engineering Willett Faculty Scholar, 2002-2009 } IBM Faculty Partnership Award, 2003-2004, 2004-2005
  • 15. Share the Vision 2015  •  Faculty Presentations  15 Ranjitha Kumar COMPUTER SCIENCE DATA-DRIVEN DESIGN ABSTRACT: The Web has transformed the nature of creative work. For the first time, millions of people have a direct outlet for sharing their creations with the world. As a result, the Web has become the largest repository of design knowledge in human history, and the ensuing “democratization of design” has created a critical feedback loop, engendering a new culture of reuse and remixing. The means and methods designers employ to draw on prior work, however, remain mostly informal and ad hoc. How can content producers find relevant examples amongst hundreds of millions of possibilities and leverage existing design practice to inform and improve their creations? My research explores data-driven techniques for working with examples at scale during the design process, automating search and curation, enabling rapid retargeting, and learning generative probabilistic models to support new design interactions. Knowledge discovery and data mining have revolutionized informatics; in this talk, I’ll discuss what we can learn from mining design. START-UP COMPANY: Personify: using the most advanced technologies in computer vision to develop fresh and immersive video experiences, which can facilitate real and meanginful connections with everyone, everywhere. (www.personify.com) RESEARCH: Human-computer interaction, with a Focus on bringing data mining and machine learning to bear on problems in design. HONORS: } ACM CHI Best Paper Award, 2013 } ACM UIST Best Paper Nomination, 2012 } Google PhD Fellowship in Design Development, 2011–2013 START-UP COMPANIES: Apropose: a start-up out of Stanford that is developing an analytics platform helps designers search, aggregate, and operationalize design data from the millions of sites on the Web. The company closed a $1.875M seed funding round co-led by New Enterprise Associates (NEA) an d Andreesen Horowitz. (www.apropose.com) DATA-DRONES OF THE SOCIOTECHNICAL SOCIETY OF FUTURE ABSTRACT: Technological advances today have the potential to transform the life of everybody within the next 20-30 years in a dramatic way. The society of non-distant future assumes co-existence of humans, pilotless planes, driverless cars, and robots, in which machines and human beings share the airspace, the roads, and populate indoor environments. This idea poses significant challenges, falling within the scope of engineering, psychology, social science, politics, ethics, and economics. Naira Hovakimyan MECHANICAL SCIENCE & ENGINEERING
  • 16. 16  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Inspired by this vision, we focus on the development of aerial co-robots that are required to safely interact with humans in a shared space and assist humans in a variety of tasks. Potential applications include building situation awareness for public safety, precision farming, health care, assisted living, filming, precision surveying, inspection and many others. RESEARCH: Robust adaptive control and estimation, networks of autonomous systems, game theory and applications of those in safety-critical systems of aerospace, mechanical, electrical, petroleum, and biomedical engineering. HONORS: } Grafton and Wilkins Professor of Mechanical Science & Engineering } Society of Women Engineers Achievement Award } American Institute of Aeronautics and Astronautics Mechanics & Control of Flight Award } Humboldt Prize, 2014 START-UP COMPANY: IntelinAir: developing data-drones for enhanced situational awareness and real-time decision making in precision farming, public safety, inspection, forestry, and many others. The company closed $1.5 million in seed funding from angel investors in January 2015, and is going for a Series A round this Fall. (www.intelinair.com)
  • 17. Share the Vision 2015  •  Faculty Presentations  17 Networked Systems & Security Brighten Godfrey COMPUTER SCIENCE BUILDING TRUSTWORTHY NETWORKS WITH VERIFICATION ABSTRACT: We rely on network infrastructure to deliver critical services and ensure security. Yet networks today have reached a level of complexity that is far beyond our ability to have confidence in their correct behavior – resulting in significant time investment and security vulnerabilities that can cost millions of dollars, or worse. In this talk, I will discuss the emerging field of network verification, which transforms network security by rigorously checking that the policy intent of a network engineer is correctly realized across the live running network. Our research work developed a technique called data plane verification, which has discovered problems in operational environments and can verify policies with millisecond-level latency in dynamic networks. In just a few years, data plane verification has moved from early research prototypes to production deployment. I’ll also discuss the future of network verification in academic research and industry. RESEARCH: Design and analysis of networked systems and algorithms, low latency networked systems, data center network architectures, software-defined networks, network security and debugging, and social network analysis algorithms. HONORS: } Sloan Fellowship, 2014 } National Science Foundation CAREER Award, 2012 } IEEE Communications Society & Information Theory Society Joint Paper Award, 2012 START-UP COMPANY: Veriflow Systems: commercializing a technology that provides a fundamental advance in the ability to secure online systems. Veriflow Systems is backed by a strong team of investors, including New Enterprise Associates (NEA), the National Science Foundation, and the US Department of Defense. (www.veriflowsystems.com)
  • 18. 18  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Robin Kravets COMPUTER SCIENCE THE INTERNET OF THINGS: THE PROMISES AND THE CHALLENGES ABSTRACT: Every day, users are interacting with hundreds and thousands of devices in both intentional and unintentional ways. Currently, these devices are being linked through local and cloud services to form an Internet of Things (IoT). As users interact with this IoT in stores, museums and other public spaces to find useful localized information, they leave breadcrumbs in the form of information traces about their presence, preferences and behavior. By intentionally exposing pieces of their personal information, users could benefit from complex services and enhanced interactions. Additionally, organizations, including retail locations and museums, can provide sophisticated benefits in exchange for this information. However, to prevent unintentional leaks of personal information, users must be able to manage their information exposure. To this end, the users and organizations need to collaborate through an IoT ecosystem that benefits both the users and organizations, while allowing the users to protect their personal information. RESEARCH: Communication issues in networks that are challenged by mobility, including wireless LANs, ad hoc networks, sensor network, delay and disruption tolerant networks, vehicular networks, mobile social networks and personal area networks with a focus on solutions that enable effective power management, connectivity management, data transport, congestion management, location management, routing and security. Klara Nahrstedt COMPUTER SCIENCE IMPACT OF ELECTRIC VEHICLES ON PHYSICAL AND DIGITAL POWER-GRID INFRASTRUCTURE ABSTRACT: With the rapid increase of electric vehicles in many urban areas, this type of transport has a major impact on the physical infrastructure and on the cyberinfrastructure of our power grid. We will discuss the impact of electric vehicles on (a) road electrification via static and dynamic wireless charging as part of the physical power grid infrastructure and (b) real-time security for V2G (Vehicle-to-Grid) communication as part of the digital power grid infrastructure. RESEARCH: : Multimedia systems, wireless and wired networks, scheduling, QoS routing, resource management for distributed multimedia systems, 3D tele-immersive systems, and trustworthy cyber-physical systems. Professor Nahrstedt is a leading researcher in multimedia systems and networks. Her fundamental work on QoS routing, energy-efficient dynamic soft-real-time CPU scheduling for mobile multimedia devices (GRACE-OS), and multi-view 3D video distribution algorithms (View-Cast, 4D-Telecast) has been widely recognized in academia and industry. HONORS: } Director, Coordinated Science Laboratory } Chair, ACM SIG Multimedia, 2007-2013 } $10,000,000 NSF Frontier Award for Trustworthy Health and Wellness (THaW), 2013
  • 19. Share the Vision 2015  •  Faculty Presentations  19 Gul Agha COMPUTER SCIENCE BUILDING SMART INFRASTRUCTURE FOR SMART CITIES ABSTRACT: Over the past 15 years, we have developed software, hardware and networking technology to support sensing as a service for the Internet of Things. We have applied our technology to provide civil infrastructure monitoring solutions. Sensing at multiple scales, we can assess structural conditions in real-time. Such assessments will rationalize maintenance as well as provide situation awareness after extreme events such as earthquakes and hurricanes. Our pilot smart sensor network deployment on bridges demonstrates an attractive value proposition for developing smart cities: providing infrastructure monitoring capabilities to increase efficiency while improving public safety. RESEARCH: Mechanisms to simplify the development of scalable parallel, distributed and mobile computing systems. Developing concurrent programming languages and systems which support applications with high-performance, fault- tolerance or real-time requirements. HONORS: } Fellow of the Institute of Electrical and Electronics Engineers (IEEE) } Former Editor-in-Chief of ACM Computer Surveys and of IEEE Parallel and Distributed Technologies } IEEE Computer Society Meritorious Service Award. START-UP COMPANY: Embedor Technologies: monitoring the structural health of civil infrastructure using wireless networked sensors that are capable of sensing at multiple scales to facilitate reliable, real-time structural condition assessment for extreme events and long-term deterioration. (www.embedortech.com) HONORS: } Co-chair, ACM MobiCom, 2013 } MobileFirst Google Focused Research Grant } Google Open Web Things Expedition
  • 20. 20  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Poster Sessions
  • 21. Share the Vision 2015  •  Poster Sessions  21 Actif ALEX LEE Actif provides wearable technology to promote the active lifestyle. Our system allows the user to effectively communicate with others sharing the road. The technology is integrated into premium build materials to give the user a seamless experience. AxoBot KUNHYUCK LEE AxoBot is developing a pre-fabricated orthosis to help any class of patients with physical disabilities to benefit from the low-cost customizable prosthesis by mass-producing the modulated actuators programmed with optimized “body- movement-algorithm.” Chairdrop DAVID KIRBY Chairdrop aims to streamline the traveling experience of people with disabilities by enabling travelers to rent wheelchairs and other medical equipment at their destination, rather than pack and travel with their own. Corvae RYAN BROWN Corvae has created a portable and wireless electrocardiograph monitor with real-time analytics and an intuitive interface. Both raw and processed data are made available wirelessly on web and mobile platforms. The Corvae heart monitoring platform will enable firefighters, nurses, and outpatients peace of mind and efficient data analysis. Corvae aims to provide intuitive displays, wireless connectivity, and real time analytics to customers in need. Cretmo Labs ADAM BURNS 42 million manual wheelchair users worldwide, face shoulder injury due to repeated pushing. I3 is a revolutionary and affordable wearable technology that tracks shoulder usage to minimize injury and improve quality of life. Electricity Demand Forecasting SPENCER GUERRERO Campus load is determined by many high electricity consumptive buildings, including labs, dormitories, office buildings, a chilled water plant and the Blue Waters supercomputer. Combining advanced statistical techniques this team has developed and deployed an algorithm that forecasts hourly campus load for the next 5 days. Back tests suggest possible savings for the Urbana campus of 20% on electricity hedging costs.
  • 22. 22  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Invoq Health MAYANK KALE Invoq Health builds intuitive and scalable mobile technologies for community health organizations. The software can be used to collect, store, transfer and analyze health data on the field. It empowers organizations to maintain a complete database of their patients and deliver effective health services at point-of-care. LAIT JOHN TOENJES AND TONY REIMER LAIT is a mobile app platform that theatrical producers use to deliver content to audience members instantly, on cue, through their phones. LAIT also can gather audience responses, making each show a two-way interactive experience. Malleable and Processable Thermoset Based on Dynamic Polyurea HANZE YING This team has developed a new type of thermosets materials based on dynamic polyurea. While keeping the advantages of conventional thermosets including high mechanical strength and solvent resistance, the new materials also show new properties of processability and recyclability induced by the feature of reversible urea bond. Psyonic AADEEL AKHTAR Psyonic develops highly advanced prosthetic hands at 10x less cost to improve the lives of people with amputations worldwide. MetroFlow NILS OBERG AND BLAKE LANDRY MetroFlow develops software tools for modeling the water quality of highly-urbanized areas with combined sewer systems. The Mouve MARCO FABREGA The Mouve allows you to create, share, and discover events with your friends and to the masses, while getting real-time footage to give you a sneak peak of what to expect.
  • 23. Share the Vision 2015  •  Poster Sessions  23 Trigger-Induced Activation of Caged Metabolic Precursor for Selective Cell Labeling and Cancer Targeting HUA WANG This team has developed a controlled labeling strategy to label cell types of interest with chemical groups. This controlled labeling strategy, coupled with various efficient Click chemistries, can be used for precise diagnosis and treatment of diseases, especially cancers. Your New Scope JIMMY NI Your New Scope produces a wearable treatment kit that makes psoriasis treatment at home easy, especially for severe cases.The product allows treatment to be monitored and adjusted in real time through app/device seamlessly by doctors.
  • 24. 24  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Start-Up Presentations SHOWN IN ORDER OF PRESENTATION
  • 25. Share the Vision 2015  •  Start-Up Presentations  25 PhotoniCare RYAN SHELTON, PHOTONICAREINC.COM Developing handheld imaging tools to revolutionize the management of middle ear infections, the leading cause of hearing loss and surgeries in children. PhotoniCare’s CLEARVIEW device improves outcomes and reduces healthcare costs, making it a win-win for everyone. Clinical studies using the device are underway at multiple locations across the U.S. The company has raised nearly $2M in non-dilutive capital in 2015 from multiple sources. } Champaign, IL BioNanoCon ABHINAV LUTHRA, BIONANOCON.COM Advancing the progress of membrane protein drug development through Nanodisc technology. Nanodiscs are nanoscale membrane bilayer patches encircled by an amphipathic alpha-helical protein called the membrane scaffold protein. By providing a native-like environment to the membrane protein target, Nanodiscs offer enhanced stability while being homogenous and monodisperse. } Urbana, IL Electrocyt BOBBY REDDY, ELECTROCYT.COM Porting the power of the traditional diagnostic labs to the comfort and convenience of local testing centers and patient’s homes with novel devices such as LifeCounts, the world’s first handheld Complete Blood Count diagnostic platform.} Champaign, IL Neurolux TONY BANKS Providing ultra-miniaturized wireless neural implant devices to the neuroscience community. Ultrathin, flexible optofluidic neural probes enable wireless delivery of agents and optical manipulation in deep brain tissue of freely behaving animals. Combinatorial optogenetic, pharmacological, and viral approaches yield a powerful tool for in vivo dissection of neural circuitry. } Champaign, IL Start-Ups in Healthcare
  • 26. 26  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Phi Optics CATALIN CHIRITESCU, PHIOPTICS.COM Developing optical imaging systems through its Quantitative Phase Imaging platfom. Phi Optic’s product is an electro-optic device that attaches to new and existing research grade optical microscopes and provides faster and more accurate imaging of live cells and tissues than currently possible with the state-of- the-art technology. } Champaign, IL IntelliWheels SCOTT DAIGLE, INTELLIWHEELS.NET Developing technology to improve mobility options for wheelchair users, including handrim grips, easy-push gears, and wheels designed to reduce stress on shoulders. } Champaign, IL Glucosentient TIAN LAN, GLUCOSENTIENT.COM Developing technology that is transforming the personal glucose meter into a device that is capable of quantitatively and conveniently detecting non-glucose targets. The technology translates the amount of non-glucose target to glucose, which is then measured by the PGM. The technology is robust and widely applicable, including heavy metal ions (environmental monitoring), small molecules (drug monitoring, drugs-of-abuse tests), protein markers (immunoassay diagnostics) and nucleic acid (molecular diagnostics) quantification. } Champaign, IL Exalt Diagnostics BRIAN CUNNINGHAM, EXALTDIAGNOSTICS.COM Imagine having a machine that can perform nearly any biological diagnostic test, including identifying an infectious disease, monitoring for the presence of biomarkers for cancer and heart disease, performing daily viral load tests, checking the authenticity of medications, and detecting allergens in food – and that your machine will instantly share results with your physician and networks of clinicians who use the information to rapidly spot trends that improve the effectiveness of healthcare in entire communities. You, and everyone you know, already owns this machine: It’s your smartphone. Exalt Diagnostics was established to commercialize patented technology from the research group of Prof. Brian Cunningham at the University of Illinois at Urbana-Champaign that enables the internal camera of any mobile device to function as a high-sensitivity and high-resolution instrument for point-of-care diagnostics. The company is leveraging NSF-funded research that has resulted in working prototype systems that have been demonstrated for several representative applications with high market potential. } Champaign, IL Aptimmune Biologics FEDERICO ZUCKERMANN, APTIMMUNE.COM Aptimmune is developing mucosal vaccines for viral diseases of swine with a focus on porcine reproductive and respiratory syndrome (PRRS) and influenza. Aptimmune’s formulations utilize patented revolutionary technologies. The first product will launch in 2016.} Champaign, IL
  • 27. Share the Vision 2015  •  Start-Up Presentations  27 BioAnalytics MICHAEL WILLARD, BIOANALYTICSYSTEMS.COM BioAnalytics is a biotechnology company developing next generation tools for protein analysis. Using a proprietary chemical method of modifying existing antibodies, BioAnalytics is able to amplify antibody binding strength by over 100X. BioAnalytics uses this technique in conjunction with a broadly applicable method of reducing immunoassay complexity and cross reactivity to provide tests with half the number of steps, 2X faster turnaround times, 100X higher sensitivity, 37X improved specificity, and 390X reduced cross reactivity in multiplexed applications. BioAnalytics is currently focused on developing tests for use in academic research and pharmaceutical development, but ultimately plans to apply their technology to point-of-care medical diagnostics. } Champaign, IL
  • 28. 28  University of Illinois at Urbana-Champaign  •  The Office of Technology Management Start-Ups in Engineering/IT Voxel8 JENNIFER LEWIS, VOXEL8.CO Providing new functional materials, such as thermoplastics and highly conductive silver ink, with a 3D printing platform to create customized electronic devices like quadcopters, electromagnets, and functional 3D electromechanical assemblies. The company recently announced $12 million in Series A financing; they have been named “one of the 50 smartest companies of 2015” by the MIT Technology Review and “one of the 9 best ideas from CES 2015” by Fast Company. } Somerville, MA FreeSkies JAY MULAKALA, FREESKIES.ORG FreeSkies envisions a world where aerial data collection is simple and accessible to everyone through the development of autono- mous software for drones. Our flagship software, the FreeSkies CoPilot, is the best way to capture aerial videos and photos with ease. You don’t need to be an expert drone pilot to capture excit- ing visuals. } San Francisco, CA OceanComm ANDY SINGER AND THOMAS RIEDL, OCEANCOMM.CO Developing a high-speed wireless underwater modem which enables wireless video streaming underwater and wireless remote control of underwater vehicles. Currently, the oil and gas industry heavily relies on remotely operated vehicles (ROVs) to find and produce resources offshore. These vehicles are all tethered today, which results in significant operational costs. A wireless solution could eliminate the costs of having to tether an ROV. } Champaign, IL Embedor Technologies GUL AGHA, EMBEDORTECH.COM Embedor Technologies is creating solutions for monitoring the structural health of civil infrastructure using wireless networked sensors. Embedor’s smart sensor platform and software framework are capable of sensing at multiple scales to facilitate reliable, real-time structural condition assessment for extreme events and long-term deterioration. } Champaign, IL
  • 29. Share the Vision 2015  •  Start-Up Presentations  29 FlipWord THOMAS REESE, GETFLIPWORD.COM Developing a browser application that switches a few words on every webpage to the user’s desired language, so he or she can learn a new language passively. FlipWord is the winner of the 2015 Cozad New Venture business plan competition at the University of Illinois. } Champaign, IL AE Machines ERIC MINNICK, AEMACHINES.COM Building tools to allow people to design and automate machine movement thereby allowing businesses to implement simple automation in their processes and realize the cost and efficiency gains that accompany such implementation. Initially, AE Machines will be a web-based software provider, allowing non-technical users to design and program simple machines via an intuitive user interface. } Champaign, IL Agrible CHRISTOPHER M. HARBOURT, AGRIBLE.COM Agrible creates analytic tools for farmers and agriculture companies that provide field-specific data and forecasts to help with decision-making in the field. Each morning, the company’s flagship product, Morning Farm Report, provides growers with information on yields, fieldwork logistics, rainfall, and more, specific to their fields. This enables them to make the best decisions based on the best agronomic data available. Agrible won the 2015 Innovation Celebration Entrepreneurial Excellence: New Venture Award. } Champaign, IL Wearifi TONY BANKS Providing the world’s thinnest, smallest, most flexible, and most lightweight near-field communication wearable device technology. } Champaign, IL Network Perception BILL SANDERS AND ROBIN BERTHIER, NETWORK-PERCEPTION.COM Developing and launching firewall analysis technology for critical infrastructures. Network Perception’s software solutions automatically audit the security and compliance of critical networks by analyzing the configurations of firewalls and routers. } Champaign, IL Harmonia RICK TAUBE, ILLIACSOFTWARE.COM Building music technologies for the 21st century. Harmonia software provides realtime music analysis, automatic grading, and course analytics. Harmonia was awarded a $225,000 STTR Phase I grant in 2014. } Champaign, IL
  • 30. Office of Technology Management University of Illinois at Urbana-Champaign, Ceramics Building, Suite 319, 105 S. Goodwin Avenue, Urbana, IL 61801 217.333.7862  •  otm@illinois.edu  •  otm.illinois.edu  •  Twitter: @ILinnovations Research Park and EnterpriseWorks University of Illinois at Urbana-Champaign, 60 Hazelwood Drive, Champaign, IL 61820 217.333.8324  •  researchpark.illinois.edu  •  Twitter: @UIResearchPark AGRICULTURE & VETERINARY MEDICINE Brad Edwards, Technology Manager 217.244.6453  •  ebedward@illinois.edu COMPUTER SCIENCE Svetlana Vranic-Sowers, Senior Technology Manager 217.244.7243  •  svsowers@illinois.edu LIFE SCIENCES Lisa Dhar, Senior Associate Director 217.333.3715  •  ldhar10@illinois.edu RK Narayanan, Ph.D., Associate Technology Manager 217.300.1614  •  rkn@illinois.edu ENGINEERING Nathan Hoffmann, Assistant Director 217.244.4747  •  nhoffma2@illinois.edu Jeffrey Wallace, Senior Technology Manager 217-265-0548  •  jrwallac@illinois.edu Steven Wille, Associate Director 217.244.5956  •  stvwille@illinois.edu ARTS, EDUCATION, SOCIAL SCIENCES & HUMANITIES Steven Wille, Associate Director 217.244.5956  •  stvwille@illinois.edu DIRECTOR Laura Frerichs  •  217.333.8323  •  lfrerich@illinois.edu DIRECTOR Lesley Millar-Nicholson  •  217.333.6807  •  millar@illinois.edu PORTFOLIO MANAGEMENT BY AREA ASSOCIATE DIRECTOR Laura Bleill  •  217.244.7744  •  lwbleill@illinois.edu
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