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WEL COME 
TOPIC-PANCREAS
What are glands ? 
Secretory organs of our body. 
Two types (i)Exocrine glands 
(ii)endocrine glands
PANCREAS -THE DUAL GLAND
LOCATION
PANCREAS 
EXOCRINE ENDOCRINE
Pancreas as endocrine function
PAUL LANGERHANS
98% OF TOTAL PANCREAS 
IS EXOCRINE
Pancreas as endocrine function
ENDOCRINE SYSTEM 
CONSISTS OF ONLY 2% OF 
TOTAL PANCREAS.
CELLS OF THE ISLET 
OF LANGERHANS
Pancreas as endocrine function
ALFA CELL BETA CELL DELTA CELL F CELL 
10-15% 30-40% 5% 3-5% 
OXYPHILIC BASOPHILIC ARGYROPHILIC 
STAINED RED AS 
MALLARY AZAN DYE ORANGE BLUE 
WELL DEV. GRANULE MORE PROMINENT SMALL SIZE GRANULES 
THAN ALFA CELL GRANULE PRESENT 
(GOLGI,ER,FREE (GOLGI,ROUGH ER, 
RIBOSOME ETC.) FREE RIBOSOME MORE) (FEW AND SMALL) 
SEC. GLUCAGON INSULIN SOMATOSTATIN PANCREATIC 
POLYPEPTIDE(PP)
PRODUCTION OF HORMONES 
1 BETA CELL INSULIN 
C-PEPTIDE 
PRO INSULIN 
AMYLIN 
2 ALFA CELL GLUCAGON 
3 DELTA CELL SOMATOSTATIN
Pancreas as endocrine function
MOL.WT=6000 ALKALINE 
12000 ACIDIC 
A-CHAIN 
(21 AMINO 
ACID) 
B-CHAIN 
(30 AMINO 
ACID) 
+ 
INSULIN 
(51 AMINO 
ACID) 
DISULPHIDE 
BRIDGE
SYNTHESIS OF INSULIN
BANTING AND BEST
Pancreas as endocrine function
Pancreas as endocrine function
BIO-FUNCTION OF INSULIN 
Transport & uptake glucose by the cells 
Promotes & inhibits glycogenesis 
Inhibits gluconeogenesis 
Preventing conversion of protein into glucose 
Accl. Protein synthesis 
Promotes synthesis of fatty acid 
Helps in storage of fat in adipose tissue
GLUCAGON
Pancreas as endocrine function
Pancreas as endocrine function
Pancreas as endocrine function
ANY QUESTION ?

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Pancreas as endocrine function