Paper tsc june 2021
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The document is a review by Dr. Trupti Chitre that explores pyrimidine pharmacophores as thymidine monophosphate kinase inhibitors for antitubercular activity. It highlights the urgent need for new antitubercular agents due to the rise of drug-resistant tuberculosis strains. The review emphasizes structure-activity relationship studies and computational analyses of nucleotide and nucleoside derivatives of pyrimidine analogs as potential TMPKMT inhibitors.
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Paper tsc june 2021
- 1. Researchpaper of Dr. Trupti Chitre Title: ExploringPyrimidinePharmacophoreasThymidineMonophosphate Kinase Inhibitorsfor AntitubercularActivity:A Review Authors: Trupti SameerChitre*,Kalyani DhirendraAsgaonkar,Shital Manoj Patil , Muthu KumaradossKathiravanandSubhashBalkrishnaPadhye Journal Details: CurrentTopicsin Medicinal Chemistry,2016, 16, 3211-3223 Publisher: BenthamScience Publishers Description: Tuberculosis(TB) hasbeen declaredasahealthemergencydue to emergence of resistant strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the current situation necessitates developing new antitubercular agents acting on novel targets for effectivelycontrollingTB.Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target, which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs reported as TMPKmt inhibitors. Photographs :