Preanalytical variables
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The document discusses preanalytical variables in medical testing that can affect the accuracy of test results, categorized into controllable and uncontrollable factors. Controllable variables include test collection, patient preparation, and lifestyle factors like diet and exercise, while uncontrollable variables encompass biological influences such as age, sex, race, and environmental conditions. Understanding these variables is crucial for ensuring that laboratory results accurately reflect a patient's health status.
Preanalytical variables
- 1. PREANALYTICAL VARIABLESPREANALYTICAL VARIABLES Tapeshwar Yadav (Lecturer) BMLT, DNHE, M.Sc. Medical Biochemistry
- 2. Defined as errors which occur when non analytical factors change the conc. of analytes,so the result do not reflect real the condition of the patient.
- 3. PREANALYTICAL VARIABLES CONTROLLABLE UNCONTROLLABLE TEST & SAMPLE COLLECTION AGE PHYSIOLOGICAL SEX DIET RACE LIFE STYLE ENVIRONMENT STIMULANTS SEASON DRUGS OBESITY HERBAL PREGNANCY RECREATIONAL SUBSTANCE STRESS FEVER
- 5. TEST & SAMPLE COLLECTION Test conducted Patient identification Turn around time Laboratory logs Transcription errors Patient preparation Specimen collection Separation ,aliquoting
- 7. POSTURE BLOOD VOLUME HEART RATE & BLOOD PRESSURE GFR ORTHOSTATIC PROTEINURIA
- 8. PROLONGED BED REST FLUID RETENTION CK & K+
- 9. EXERCISE BLOOD GLUCOSE LACTATE URATE PLASMA LIPIDS HORMONES FFA CREATININE BUN.
- 10. PHYSICAL TRAINING SERUM ENZYMES OF MUSCULAR ORIGIN NPN T4 LIPID
- 11. CIRCADION VARIATION CORTISOL RENIN& ALDOSTERONE TSH GROWTH HORMONE
- 13. DIET HIGH PROTEIN FAT SUCROSE & CARBOHYDRATE
- 14. FOOD INGESTION FASTING & POST PRANDIAL ALKALINE TIDE AFTER MEAL GTT SPECIFIC FOOD CAFFEINE
- 15. VEGETARIANISM LIPID URINARY pH VIT B₁₂.
- 16. MALNUTRITION PROTEIN (S) LIPID T4 TSH.
- 17. FASTING & STARVATION BLOOD GLUCOSE INSULIN GLUCAGON LYPOLYSIS KETOGENESIS BR. CHAIN AMINO ACIDS PROTEIN (S) URINARY EXCRETION OF NH₃ & CREATININE.
- 18. LIFE STYLE
- 19. SMOKING NICOTINE PLASMA EPINEPHRINE, GLUCOSE & INSULIN LACTATE LIPIDS CORTISOL CARBOXYHEMOGLOBIN GASTRIC JUICE IMMUNOGLOBULINS VIT B12
- 20. ALCOHOL GLUCOSE INHIBITION OF GLUCONEOGENESIS LACTATE & URATE TGL & HDL CORTISOL GGT.
- 21. DRUGS SIDE EFFECTS THIAZIDES- HYPERGLYCEMIA, PHENYTOIN- BILIRUBIN CONJUGATING ENZYMES.
- 22. RECREATIONAL SUBSTANCES AMPHETAMINES -FFA MORPHINE -AMYLASE&LIPASE HEROIN – CHOLESTEROL,THYROXIN
- 24. BIOLOGICAL INFLUENCES BETTER AGREEMENT BETWEEN SERUM CONC OR ACTIVITIES OF CONSTITUENTS IN MONOZYGOTIC THAN IN DIZYGOTIC TWINS. IN WOMEN & BLOOD GR ‘O’- Hb CONC < OTHER BOOD GR.
- 25. AGE NEW BORN- -CHANGES RELATED TO INFANTS ADAPTATION TO INDEPENDENT EXISTENCE -R.B.C COUNT & Hb CONC. Hb F, PHYSIOLOGICAL JAUNDICE, BLOOD GLUCOSE, PLASMA AMINO ACID CONC. CHILDHOOD TO PUBERTY- -PLASMA PROTEIN , ADULT- ELDERLY- -CREATINE CLEARANCE, T3, INSULIN.
- 26. SEX CH. CHANGES AFTER PUBERTY- -ENZYMES -LIPID -NPN
- 27. RACE TOTAL PROTEIN ALBUMIN GLUCOSE TOLERANCE Hb
- 28. ENVIRONMENTAL ALTITUDE AMBIENT TEMPERATURE RESIDENCE SEASONAL
- 29. MEDICAL CONDITIONS OBESITY PREGNANCY STRESS FEVER