The document investigates the enhancement of heat transfer in microchannels using nanofluids and longitudinal vortex generators (LVGs), focusing on thermal and hydraulic performance. It highlights the potential of nanofluids, particularly Al2O3-water and CuO-PAO, as effective alternatives to conventional coolants for cooling applications in microelectronics. The study utilizes simulations validated against experimental data, concluding that configuration A1 with specific nanofluids offers optimal performance.