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For producer information only. Not for use in sales situations.
Principal Financial Group®
Life New Business & Underwriting
Basics of the Echocardiogram:
Diastolic Dysfunction & Left Ventricular
Hypertrophy (LVH)
Cindy Miller
Senior Underwriting Consultant
Jon Leinen
Technical Underwriting Director
For producer information only. Not for use in sales situations.
The Echo
History
• The technology of sonar or echosonography was
originally developed during World War II to detect
submarines
• The first “echo” was in the early 1950s. A Swedish
physicist borrowed a sonar device from a local
shipyard, modified it, and recorded echo’s from his
own heart
For producer information only. Not for use in sales situations.
The Echo
Uses of the Ultrasound (US)
• Gynecology and obstetrics
• Vascular issues
• Musculoskeletal issues
• Detection of tumors in various areas in the body: prostate,
colon, breast, heart, gastointestinal tract and other organs
• Cardiology
For producer information only. Not for use in sales situations.
The Echo
Cardiac Arena used for:
• Identification of structures of the heart (normal and abnormal)
• Allows for assessment of the motion and function of the heart and it’s
various structures
• Follows blood flow through the heart and measures velocity of the
blood flow
• Serves as a compliment to other diagnostic tests (eg. confirms EKG
findings for LVH or chest x ray finding; can be helpful assessing
degree of coronary plaque - via US that is done simultaneously with
cath.)
For producer information only. Not for use in sales situations.
The Echo
How is it completed?
• It involves a US machine, a wand which is known as a
transducer that is connected to a US machine
• The patient lies on stretcher and the echosonographer who
has been specifically trained in techniques of
echosonography performs the scan
• The scan is completed in a very systematic format to obtain
specific views of the heart that the cardiologists expects to
see on any given echo
For producer information only. Not for use in sales situations.
The Echo
• 3 inter-related processes utilized
during an ECHO
– M mode
– 2-D component
– Doppler (continuous wave/pulses wave/
color flow)
For producer information only. Not for use in sales situations.
The Echo
M Mode
– Single dimension picture
– Enables us to look closely and measure the heart
chambers and structures, the aorta (helpful with
LVH, myxomatous valves, valvular stenosis,
hypertrophic & dilated cardiomyopathies)
– Can also play a role in the assessment of some
valve functions
For producer information only. Not for use in sales situations.
The Echo
M Mode (LVID and Wall measurements / MV motion)
For producer information only. Not for use in sales situations.
The Echo
2D Mode
– Two dimensional picture of the heart is produced as result of sound waves
going out of the transducer and bouncing off a structure and then returning
back to the transducer
2D - 4 Chamber apical view
Diastole
MV open
Systole
MV closed
For producer information only. Not for use in sales situations.
The Echo
2D -parasternal
For producer information only. Not for use in sales situations.
The Echo
Doppler Mode
– Evaluates the path of the blood flow
– Evaluates the blood flow velocity as it moves through the
heart and its structures
3 Types Doppler :
– Pulsed Wave
– Continuous Wave
– Color Flow
For producer information only. Not for use in sales situations.
The Echo
Pulsed Wave Doppler
Measures velocity of blood as it moves through the heart
• Helps to assess how heart muscle squeezes (systole) & relaxes (diastole)
E/A ratio
For producer information only. Not for use in sales situations.
The Echo
Continuous Wave Doppler
• Measures blood flow velocity as it moves through the
valves
• Measure degree of valvular regurgitation measuring the
density, length and shape of the wave forms
• Helps to quantify how severely a valve is leaking
For producer information only. Not for use in sales situations.
The Echo
• CW- Aortic Regurg
Mitral RegurgitationAortic Insufficiency
Continuous Wave
Doppler
For producer information only. Not for use in sales situations.
The Echo
Color Flow Doppler
• Measures the velocity and direction of blood flow via color
patterns
For producer information only. Not for use in sales situations.
The Echo
Color Flow Doppler
MV Open MV Closed
For producer information only. Not for use in sales situations.
The Echo
Putting it all together
• During the test the images that have been obtained (M
mode/2 D images and Doppler) are recorded for later
viewing by the MD
• The technician writes a report of their interpretation of the
findings and prepares the report and a recording of the
entire echo for the MD to review
• MD provides a final analysis from the recording/the
interpretation
For producer information only. Not for use in sales situations.
The Echo
What Underwriters should note when reviewing the
report:
• Why was it completed?
• Patient data (being aware of the persons age/any disease
processes/body size )
• Quality of the image
• Assess the entire report and try not to focus on just
one aspect *****
• Do the findings make sense with the overall clinical
picture? *****
For producer information only. Not for use in sales situations.
The Echo
Limitations & Variables
• Interpretation of the echo can be somewhat subjective
• Body habitus and other physical deformities can alter the
findings and ability to accurately obtain some of the images
• Equipment variables
• Sonographer technique and experience
• Some of the findings can’t be reproduced and are time
specific
For producer information only. Not for use in sales situations.
The Echo
Additional Considerations
• Don’t take an isolated reading and automatically rate it,
instead consider the following…
– Compare to prior echos
– Take age and body habits into consideration
– Note the BP and other impairment history
– Note why the test was done in the first place
– What if any clinical signs/symptoms are present
– What other clinical data is present that support the findings
For producer information only. Not for use in sales situations.
The Echo
Common Abnormal Echo Findings
• LVH
• Concentric (hypertension, valve diseases, aortic stenosis,
cardiomyopathies, obesity)
• Asymmetric Septal Hypertrophy (ASH), Valve disease
• Abnormal Wall Motion
• Global hypokensis (HK) (cardiomyopathies)
• Segmental HK or akinesia (AK) (ischemic heart disease)
• Dyskinesia (aneurysms, LBBB)
For producer information only. Not for use in sales situations.
The Echo
Common Abnormal Echo Findings cont…
– Abnormal Valves - stenosis , insufficiency, bicuspid AV
– MAC (Mitral annular calcification), thickened cusps, calcium deposits
– Diastolic dysfunction
– PFO / ASD
– Atrial Enlargements (valve disease, diastolic dysfunction or atrial fib)
– Aortic Root enlargements (CTD, valve disease)
For producer information only. Not for use in sales situations.
The Echo
Less Common Findings…
• Tumors (malignant or benign)
• Pericardial effusions
• Congenital defects (great vessel anomalies)
For producer information only. Not for use in sales situations.
The Echo
Normal findings on a typical Elderly person ..
• LV wall thickness increases 15%;
• LV mass increases 1 gm/yr from ages 65-80
– senile septum ( septum thickens slightly )
• LA dimensions increase ~ 16%
For producer information only. Not for use in sales situations.
The Echo
Normal findings on Elderly person cont…
• LV dimension unchanged
• Aortic Root diameter increases ~ 22%
• E/A velocity is often reversed ( diastolic dysfunction )
• Valvular disease and MAC
For producer information only. Not for use in sales situations.
The Echo
Normal Dimensions / Adult 2D-Echo
Right ventricular dimension (RVD) 1.9 - 2.8
Left ventricular end diastolic dimension
(LVEDD)
3.5 - 6.0
Left ventricular end systolic dimension
(LVESD)
2.1 - 4.0
Posterior LV wall thickness (PW) 0.6 - 1.1
Interventricular septum wall thickness (IVS) 0.6 - 1.1
Mild enlargement 1.2 – 1.3
Mod 1.4 – 1.5
Severe 1.6 – 1.7
Left atrial dimension (LA) 1.9 - 4.0
Aortic root dimension (AR) 2.0 - 3.7
Cusp separation - aortic valve 1.5 - 2.6
Fractional shortening (FS) 25 – 42%
Ejection fraction (EF) 50 – 59%
Pulmonary Artery Pressure (RSVP) Up to 40
For producer information only. Not for use in sales situations.
Echocardiogram Reference Ranges-
Left Atrium
Female Normal
Range
Mildly Abnormal Moderately
Abnormal
Severely
Abnormal
LA Diameter, cm 2.7 – 3.8 3.9 – 4.2 4.3 – 4.6 ≥ 4.7
LA Diameter BSA, cm 1.5 – 2.3 2.4 – 2.6 2.7 – 2.9 ≥ 3.0
LA Area ≤ 20 21 – 30 31 – 40 ≥ 40
LA Volume, ml 22 – 52 53 – 62 63 - 72 ≥ 73
Male Normal
Range
Mildly Abnormal Moderately
Abnormal
Severely
Abnormal
LA Diameter, cm 3.0 – 4.0 4.1 – 4.6 4.7 – 5.2 ≥ 5.3
LA Diameter BSA, cm 1.5 – 2.3 2.4 – 2.6 2.7 – 2.9 ≥ 3.0
LA Area ≤ 20 21 – 30 31 – 40 ≥ 40
LA Volume, ml 18 – 58 59 – 68 69 - 78 ≥ 79
LA Volume Index: Normal ≤ 28 ml/m²; Mild to Moderate- 29-39ml/m²; Severe- >40 ml/m²
Women and Men:
For producer information only. Not for use in sales situations.
Diastolic Dysfunction
LEFT VENTRICULAR DYSFUNCTION
• The Basics
– The heart is a pump: it has to be able to fill up (diastole) and then it
has to be able pump the blood out (systole)
• Systolic dysfunction
– Pump failure equates to a low Ejection Fraction (EF) -
Cardiomyopathy / CAD
– Heart muscle is damaged and is unable to pump the blood out to
the body normally
For producer information only. Not for use in sales situations.
Diastolic Dysfuntion
Diastolic dysfunction
• LV can’t fill normally due to impaired relaxation/or restriction
• Ventricular systolic function is preserved
• Incidence increases with age and is seen in some degree in
at least 50% of older patients
• More prevalent in women
• Signs and symptoms may be the same as in systolic failure
For producer information only. Not for use in sales situations.
Diastolic Dysfunction
Pathophysiology of Diastolic dysfunction:
• Normally the LV is passively filled, and then the atria
contract and that provides additional “atrial packing.”
• In diastolic dysfunction the left ventricle cannot fill up with
blood normally due to a hard stiff and non compliant LV and
the blood has to be forced in
For producer information only. Not for use in sales situations.
Diastolic Dysfuntion
Causes of Diastolic Dysfunction
• Aging - lose general elasticity
• HTN - general wear and tear on the heart muscle causing it
to hypertrophy and become stiff
• Aortic stenosis - LV becomes stiff because it’s
overworked
• MI - scarring, damaged muscle
• Ischemic heart disease - damaged muscle
• Obesity - increases the workload and the muscle
hypertrophies and becomes stiff and non compliant
For producer information only. Not for use in sales situations.
Diastolic Dysfuntion
Prognosis
• Depends on the degree of diastolic dysfunction
• If severe, can be as grim as systolic failure
For producer information only. Not for use in sales situations.
Diastolic Dysfunction
Signs & Symptoms
• Shortness of Breath / Dyspnea on Exertion
• SM and or S4 present
• Pedal edema
• Systolic Hypertension
• Increased proBNP (brain naturetic peptide - hormone made by the
heart that increases when the heart is stressed
For producer information only. Not for use in sales situations.
Diastolic Dysfuntion
Echo findings that support diagnosis of Diastolic
Dysfunction:
• Abnormal E/A ratio –
– E/A ratio is the ratio between passive filling and active
filling of the LV (normally the E wave is 80% process and
A wave is 20%; in diastolic dysfunction this ratio is
reversed)
For producer information only. Not for use in sales situations.
Diastolic Dysfunction
Normal E/A ratio
First spike = E wave / Second smaller spike = A wave
.
For producer information only. Not for use in sales situations.
Diastolic Dysfunction
Diastolic Dysfunction
– Equates to reversed
E/A ratio (smaller E
wave - taller A wave)
For producer information only. Not for use in sales situations.
Diastolic Dysfunction
Four Echocardiographic Patterns of Diastolic
Dysfunction
• Grade I
– Abnormal relaxation
– Reversal of E/A ratio
– Some of this is normal with aging
– No significant clinical signs or symptoms
For producer information only. Not for use in sales situations.
Diastolic Dysfuntion
Four Echocardiographic Patterns of Diastolic
Dysfunction
• Grade II
– Pseudo-normal filling (poorer prognosis at this stage)
– Moderate diastolic dysfunction
– Clinical symptoms apparent as well as have LAE and increased
filling pressures
– Having more symptoms of SOB and possibly some edema
– Decreased exercise capacity
For producer information only. Not for use in sales situations.
Diastolic Dysfunction
• Grade III - IV Diastolic Dysfunction
– Restrictive filling
– Advanced diastolic dysfunction
– Left Atrial enlarged significantly
– May also have reduced EF
– This would be diastolic heart failure rather than systolic
failure. (Often hard to differentiate whether its systolic or
diastolic failure at this because of the complex issues at
play and it’s probable they could be experiencing both at
this point)
For producer information only. Not for use in sales situations.
Diastolic Dysfuntion
Treatment
Treat the cause / reduce the workload……
• Control hypertension
• Control the heart rate - maximize diastole/filling period (beta blockers)
• Improve LV relaxation (calcium channel blockers/ace
inhibitors/angiotensin receptor blockers)
• Decrease the resistance the heart pumps against (afterload) and or
decrease the filling pressure/pre-load by use of vasodilators
• Monitor build and salt intake
• Lose weight and exercise
• Regular follow up
For producer information only. Not for use in sales situations.
The Echo: Case Study #1
– 73 male NS
– 72 inches 260 #
– NIDDM & HTN.
– Six months ago went to Emergency room complaining of SOB. No
chest pain or palpitations. Last year had EBCT calcium score 10.
– BP 180/100
– Grade II/VI SEM ; S4
– 2 + Pedal edema
– Ecg increased voltage
– Chest x-ray mild cardiomegaly
For producer information only. Not for use in sales situations.
Case Study
Echo
- Mild Aortic stenosis
- EF 50%
- Reversed E/A ratio
- IVS-1.2 ; PW-1.3
- LVID 5.6; LA 4.6
- Right sided chambers mildly dilated.
- Mild TR and RSVP 39
For producer information only. Not for use in sales situations.
Case Study
RECAP ----Indicators that he may have significant diastolic dysfunction
– NL EF and still having unexplained symptoms not otherwise
accounted for by another disease
– Age and build
– Long standing htn not optimally controlled
– AS
– S4 ( noncompliant ventricle)
For producer information only. Not for use in sales situations.
Left Ventricular Hypertrophy (LVH)
LVH …
Ecg- increased voltage on the ecg tracing
– Chest x-ray- cardiomegaly
– Echocardiogram- measurement of the thickness of the LV
wall
The most specific test for LVH is from the echo
For producer information only. Not for use in sales situations.
LVH
• Normal LV wall thickness: 0.6 cm to 1.1 cm
• LVH (LV wall thickness)
• Mild: 1.2-1.3 cm
• Moderate: 1.4-1.5 cm
• Severe: 1.6-1.7 cm
• Extreme: >1.7 cm
For producer information only. Not for use in sales situations.
LVH
• 2 measurements to look for on the echocardiogram
for LVH:
• Posterior LV wall thickness (PW) - normal -0.6 - 1.1
• Interventricular septum wall thickness (IVS) - 0.6 - 1.1
For producer information only. Not for use in sales situations.
LVH
For producer information only. Not for use in sales situations.
LVH
• What is 1 cm wide?
For producer information only. Not for use in sales situations.
LVH
• Not much in actual difference between 1.0 and 1.7
cm. However there is very significant mortality risk
with this relatively small difference when talking about
the left ventricle wall thickness
For producer information only. Not for use in sales situations.
LVH
• Concentric - enlargement of the wall that is the same
for both the posterior wall and the septal wall
• Asymetrical - differences in thickness of the walls.
10% of cases, left ventricular hypertrophy may
manifest on echocardiograms in an asymmetric
– May indicate possible hypertrophic cardiomyopathy
For producer information only. Not for use in sales situations.
Causes of LVH
• Hypertension
• Heart valve disorder such as aortic valve stenosis
• Ischemia
• Cardiomyopathy
• Nutritional disorder
• Endocrine disorder
• Congenital heart disease
• Toxins- alcohol, drugs
For producer information only. Not for use in sales situations.
What is LV Mass
• Takes into account gender and size of the individual
as well as LVEDd, PWT, and IVS to determine the
relative size (mass) of the LV
• Increased LV mass is also associated with an
increased riskfor sudden cardiac death
• Measurements of LV mass must be interpreted in the
clinical context
• In clinical practice, however, the presence of LVH is
more commonly defined by wall thickness
For producer information only. Not for use in sales situations.
LVH: Assessment
How do we assess LVH?
• Look for underlying cause, any clinical
symptoms/findings- primary reasons for LVH are
hypertension and valve disorder
• Mild- as good as standard/preferred, depending on
history
• Moderate- likely mildly to moderate ratable
• Severe- highly rated, if we can offer
For producer information only. Not for use in sales situations.
Contact information:
Cindy Miller: Miller.cindy@principal.com
PH: 515-235-9285
Jon Leinen: Leinen.jon@principal.com
PH: 515-247-6672
Contact for Questions
For producer information only. Not for use in sales situations.
Questions

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Principal basics of the echocardiogram diastolic dysfunction and left ventricular hypertrophy

  • 1. For producer information only. Not for use in sales situations. Principal Financial Group® Life New Business & Underwriting Basics of the Echocardiogram: Diastolic Dysfunction & Left Ventricular Hypertrophy (LVH) Cindy Miller Senior Underwriting Consultant Jon Leinen Technical Underwriting Director
  • 2. For producer information only. Not for use in sales situations. The Echo History • The technology of sonar or echosonography was originally developed during World War II to detect submarines • The first “echo” was in the early 1950s. A Swedish physicist borrowed a sonar device from a local shipyard, modified it, and recorded echo’s from his own heart
  • 3. For producer information only. Not for use in sales situations. The Echo Uses of the Ultrasound (US) • Gynecology and obstetrics • Vascular issues • Musculoskeletal issues • Detection of tumors in various areas in the body: prostate, colon, breast, heart, gastointestinal tract and other organs • Cardiology
  • 4. For producer information only. Not for use in sales situations. The Echo Cardiac Arena used for: • Identification of structures of the heart (normal and abnormal) • Allows for assessment of the motion and function of the heart and it’s various structures • Follows blood flow through the heart and measures velocity of the blood flow • Serves as a compliment to other diagnostic tests (eg. confirms EKG findings for LVH or chest x ray finding; can be helpful assessing degree of coronary plaque - via US that is done simultaneously with cath.)
  • 5. For producer information only. Not for use in sales situations. The Echo How is it completed? • It involves a US machine, a wand which is known as a transducer that is connected to a US machine • The patient lies on stretcher and the echosonographer who has been specifically trained in techniques of echosonography performs the scan • The scan is completed in a very systematic format to obtain specific views of the heart that the cardiologists expects to see on any given echo
  • 6. For producer information only. Not for use in sales situations. The Echo • 3 inter-related processes utilized during an ECHO – M mode – 2-D component – Doppler (continuous wave/pulses wave/ color flow)
  • 7. For producer information only. Not for use in sales situations. The Echo M Mode – Single dimension picture – Enables us to look closely and measure the heart chambers and structures, the aorta (helpful with LVH, myxomatous valves, valvular stenosis, hypertrophic & dilated cardiomyopathies) – Can also play a role in the assessment of some valve functions
  • 8. For producer information only. Not for use in sales situations. The Echo M Mode (LVID and Wall measurements / MV motion)
  • 9. For producer information only. Not for use in sales situations. The Echo 2D Mode – Two dimensional picture of the heart is produced as result of sound waves going out of the transducer and bouncing off a structure and then returning back to the transducer 2D - 4 Chamber apical view Diastole MV open Systole MV closed
  • 10. For producer information only. Not for use in sales situations. The Echo 2D -parasternal
  • 11. For producer information only. Not for use in sales situations. The Echo Doppler Mode – Evaluates the path of the blood flow – Evaluates the blood flow velocity as it moves through the heart and its structures 3 Types Doppler : – Pulsed Wave – Continuous Wave – Color Flow
  • 12. For producer information only. Not for use in sales situations. The Echo Pulsed Wave Doppler Measures velocity of blood as it moves through the heart • Helps to assess how heart muscle squeezes (systole) & relaxes (diastole) E/A ratio
  • 13. For producer information only. Not for use in sales situations. The Echo Continuous Wave Doppler • Measures blood flow velocity as it moves through the valves • Measure degree of valvular regurgitation measuring the density, length and shape of the wave forms • Helps to quantify how severely a valve is leaking
  • 14. For producer information only. Not for use in sales situations. The Echo • CW- Aortic Regurg Mitral RegurgitationAortic Insufficiency Continuous Wave Doppler
  • 15. For producer information only. Not for use in sales situations. The Echo Color Flow Doppler • Measures the velocity and direction of blood flow via color patterns
  • 16. For producer information only. Not for use in sales situations. The Echo Color Flow Doppler MV Open MV Closed
  • 17. For producer information only. Not for use in sales situations. The Echo Putting it all together • During the test the images that have been obtained (M mode/2 D images and Doppler) are recorded for later viewing by the MD • The technician writes a report of their interpretation of the findings and prepares the report and a recording of the entire echo for the MD to review • MD provides a final analysis from the recording/the interpretation
  • 18. For producer information only. Not for use in sales situations. The Echo What Underwriters should note when reviewing the report: • Why was it completed? • Patient data (being aware of the persons age/any disease processes/body size ) • Quality of the image • Assess the entire report and try not to focus on just one aspect ***** • Do the findings make sense with the overall clinical picture? *****
  • 19. For producer information only. Not for use in sales situations. The Echo Limitations & Variables • Interpretation of the echo can be somewhat subjective • Body habitus and other physical deformities can alter the findings and ability to accurately obtain some of the images • Equipment variables • Sonographer technique and experience • Some of the findings can’t be reproduced and are time specific
  • 20. For producer information only. Not for use in sales situations. The Echo Additional Considerations • Don’t take an isolated reading and automatically rate it, instead consider the following… – Compare to prior echos – Take age and body habits into consideration – Note the BP and other impairment history – Note why the test was done in the first place – What if any clinical signs/symptoms are present – What other clinical data is present that support the findings
  • 21. For producer information only. Not for use in sales situations. The Echo Common Abnormal Echo Findings • LVH • Concentric (hypertension, valve diseases, aortic stenosis, cardiomyopathies, obesity) • Asymmetric Septal Hypertrophy (ASH), Valve disease • Abnormal Wall Motion • Global hypokensis (HK) (cardiomyopathies) • Segmental HK or akinesia (AK) (ischemic heart disease) • Dyskinesia (aneurysms, LBBB)
  • 22. For producer information only. Not for use in sales situations. The Echo Common Abnormal Echo Findings cont… – Abnormal Valves - stenosis , insufficiency, bicuspid AV – MAC (Mitral annular calcification), thickened cusps, calcium deposits – Diastolic dysfunction – PFO / ASD – Atrial Enlargements (valve disease, diastolic dysfunction or atrial fib) – Aortic Root enlargements (CTD, valve disease)
  • 23. For producer information only. Not for use in sales situations. The Echo Less Common Findings… • Tumors (malignant or benign) • Pericardial effusions • Congenital defects (great vessel anomalies)
  • 24. For producer information only. Not for use in sales situations. The Echo Normal findings on a typical Elderly person .. • LV wall thickness increases 15%; • LV mass increases 1 gm/yr from ages 65-80 – senile septum ( septum thickens slightly ) • LA dimensions increase ~ 16%
  • 25. For producer information only. Not for use in sales situations. The Echo Normal findings on Elderly person cont… • LV dimension unchanged • Aortic Root diameter increases ~ 22% • E/A velocity is often reversed ( diastolic dysfunction ) • Valvular disease and MAC
  • 26. For producer information only. Not for use in sales situations. The Echo Normal Dimensions / Adult 2D-Echo Right ventricular dimension (RVD) 1.9 - 2.8 Left ventricular end diastolic dimension (LVEDD) 3.5 - 6.0 Left ventricular end systolic dimension (LVESD) 2.1 - 4.0 Posterior LV wall thickness (PW) 0.6 - 1.1 Interventricular septum wall thickness (IVS) 0.6 - 1.1 Mild enlargement 1.2 – 1.3 Mod 1.4 – 1.5 Severe 1.6 – 1.7 Left atrial dimension (LA) 1.9 - 4.0 Aortic root dimension (AR) 2.0 - 3.7 Cusp separation - aortic valve 1.5 - 2.6 Fractional shortening (FS) 25 – 42% Ejection fraction (EF) 50 – 59% Pulmonary Artery Pressure (RSVP) Up to 40
  • 27. For producer information only. Not for use in sales situations. Echocardiogram Reference Ranges- Left Atrium Female Normal Range Mildly Abnormal Moderately Abnormal Severely Abnormal LA Diameter, cm 2.7 – 3.8 3.9 – 4.2 4.3 – 4.6 ≥ 4.7 LA Diameter BSA, cm 1.5 – 2.3 2.4 – 2.6 2.7 – 2.9 ≥ 3.0 LA Area ≤ 20 21 – 30 31 – 40 ≥ 40 LA Volume, ml 22 – 52 53 – 62 63 - 72 ≥ 73 Male Normal Range Mildly Abnormal Moderately Abnormal Severely Abnormal LA Diameter, cm 3.0 – 4.0 4.1 – 4.6 4.7 – 5.2 ≥ 5.3 LA Diameter BSA, cm 1.5 – 2.3 2.4 – 2.6 2.7 – 2.9 ≥ 3.0 LA Area ≤ 20 21 – 30 31 – 40 ≥ 40 LA Volume, ml 18 – 58 59 – 68 69 - 78 ≥ 79 LA Volume Index: Normal ≤ 28 ml/m²; Mild to Moderate- 29-39ml/m²; Severe- >40 ml/m² Women and Men:
  • 28. For producer information only. Not for use in sales situations. Diastolic Dysfunction LEFT VENTRICULAR DYSFUNCTION • The Basics – The heart is a pump: it has to be able to fill up (diastole) and then it has to be able pump the blood out (systole) • Systolic dysfunction – Pump failure equates to a low Ejection Fraction (EF) - Cardiomyopathy / CAD – Heart muscle is damaged and is unable to pump the blood out to the body normally
  • 29. For producer information only. Not for use in sales situations. Diastolic Dysfuntion Diastolic dysfunction • LV can’t fill normally due to impaired relaxation/or restriction • Ventricular systolic function is preserved • Incidence increases with age and is seen in some degree in at least 50% of older patients • More prevalent in women • Signs and symptoms may be the same as in systolic failure
  • 30. For producer information only. Not for use in sales situations. Diastolic Dysfunction Pathophysiology of Diastolic dysfunction: • Normally the LV is passively filled, and then the atria contract and that provides additional “atrial packing.” • In diastolic dysfunction the left ventricle cannot fill up with blood normally due to a hard stiff and non compliant LV and the blood has to be forced in
  • 31. For producer information only. Not for use in sales situations. Diastolic Dysfuntion Causes of Diastolic Dysfunction • Aging - lose general elasticity • HTN - general wear and tear on the heart muscle causing it to hypertrophy and become stiff • Aortic stenosis - LV becomes stiff because it’s overworked • MI - scarring, damaged muscle • Ischemic heart disease - damaged muscle • Obesity - increases the workload and the muscle hypertrophies and becomes stiff and non compliant
  • 32. For producer information only. Not for use in sales situations. Diastolic Dysfuntion Prognosis • Depends on the degree of diastolic dysfunction • If severe, can be as grim as systolic failure
  • 33. For producer information only. Not for use in sales situations. Diastolic Dysfunction Signs & Symptoms • Shortness of Breath / Dyspnea on Exertion • SM and or S4 present • Pedal edema • Systolic Hypertension • Increased proBNP (brain naturetic peptide - hormone made by the heart that increases when the heart is stressed
  • 34. For producer information only. Not for use in sales situations. Diastolic Dysfuntion Echo findings that support diagnosis of Diastolic Dysfunction: • Abnormal E/A ratio – – E/A ratio is the ratio between passive filling and active filling of the LV (normally the E wave is 80% process and A wave is 20%; in diastolic dysfunction this ratio is reversed)
  • 35. For producer information only. Not for use in sales situations. Diastolic Dysfunction Normal E/A ratio First spike = E wave / Second smaller spike = A wave .
  • 36. For producer information only. Not for use in sales situations. Diastolic Dysfunction Diastolic Dysfunction – Equates to reversed E/A ratio (smaller E wave - taller A wave)
  • 37. For producer information only. Not for use in sales situations. Diastolic Dysfunction Four Echocardiographic Patterns of Diastolic Dysfunction • Grade I – Abnormal relaxation – Reversal of E/A ratio – Some of this is normal with aging – No significant clinical signs or symptoms
  • 38. For producer information only. Not for use in sales situations. Diastolic Dysfuntion Four Echocardiographic Patterns of Diastolic Dysfunction • Grade II – Pseudo-normal filling (poorer prognosis at this stage) – Moderate diastolic dysfunction – Clinical symptoms apparent as well as have LAE and increased filling pressures – Having more symptoms of SOB and possibly some edema – Decreased exercise capacity
  • 39. For producer information only. Not for use in sales situations. Diastolic Dysfunction • Grade III - IV Diastolic Dysfunction – Restrictive filling – Advanced diastolic dysfunction – Left Atrial enlarged significantly – May also have reduced EF – This would be diastolic heart failure rather than systolic failure. (Often hard to differentiate whether its systolic or diastolic failure at this because of the complex issues at play and it’s probable they could be experiencing both at this point)
  • 40. For producer information only. Not for use in sales situations. Diastolic Dysfuntion Treatment Treat the cause / reduce the workload…… • Control hypertension • Control the heart rate - maximize diastole/filling period (beta blockers) • Improve LV relaxation (calcium channel blockers/ace inhibitors/angiotensin receptor blockers) • Decrease the resistance the heart pumps against (afterload) and or decrease the filling pressure/pre-load by use of vasodilators • Monitor build and salt intake • Lose weight and exercise • Regular follow up
  • 41. For producer information only. Not for use in sales situations. The Echo: Case Study #1 – 73 male NS – 72 inches 260 # – NIDDM & HTN. – Six months ago went to Emergency room complaining of SOB. No chest pain or palpitations. Last year had EBCT calcium score 10. – BP 180/100 – Grade II/VI SEM ; S4 – 2 + Pedal edema – Ecg increased voltage – Chest x-ray mild cardiomegaly
  • 42. For producer information only. Not for use in sales situations. Case Study Echo - Mild Aortic stenosis - EF 50% - Reversed E/A ratio - IVS-1.2 ; PW-1.3 - LVID 5.6; LA 4.6 - Right sided chambers mildly dilated. - Mild TR and RSVP 39
  • 43. For producer information only. Not for use in sales situations. Case Study RECAP ----Indicators that he may have significant diastolic dysfunction – NL EF and still having unexplained symptoms not otherwise accounted for by another disease – Age and build – Long standing htn not optimally controlled – AS – S4 ( noncompliant ventricle)
  • 44. For producer information only. Not for use in sales situations. Left Ventricular Hypertrophy (LVH) LVH … Ecg- increased voltage on the ecg tracing – Chest x-ray- cardiomegaly – Echocardiogram- measurement of the thickness of the LV wall The most specific test for LVH is from the echo
  • 45. For producer information only. Not for use in sales situations. LVH • Normal LV wall thickness: 0.6 cm to 1.1 cm • LVH (LV wall thickness) • Mild: 1.2-1.3 cm • Moderate: 1.4-1.5 cm • Severe: 1.6-1.7 cm • Extreme: >1.7 cm
  • 46. For producer information only. Not for use in sales situations. LVH • 2 measurements to look for on the echocardiogram for LVH: • Posterior LV wall thickness (PW) - normal -0.6 - 1.1 • Interventricular septum wall thickness (IVS) - 0.6 - 1.1
  • 47. For producer information only. Not for use in sales situations. LVH
  • 48. For producer information only. Not for use in sales situations. LVH • What is 1 cm wide?
  • 49. For producer information only. Not for use in sales situations. LVH • Not much in actual difference between 1.0 and 1.7 cm. However there is very significant mortality risk with this relatively small difference when talking about the left ventricle wall thickness
  • 50. For producer information only. Not for use in sales situations. LVH • Concentric - enlargement of the wall that is the same for both the posterior wall and the septal wall • Asymetrical - differences in thickness of the walls. 10% of cases, left ventricular hypertrophy may manifest on echocardiograms in an asymmetric – May indicate possible hypertrophic cardiomyopathy
  • 51. For producer information only. Not for use in sales situations. Causes of LVH • Hypertension • Heart valve disorder such as aortic valve stenosis • Ischemia • Cardiomyopathy • Nutritional disorder • Endocrine disorder • Congenital heart disease • Toxins- alcohol, drugs
  • 52. For producer information only. Not for use in sales situations. What is LV Mass • Takes into account gender and size of the individual as well as LVEDd, PWT, and IVS to determine the relative size (mass) of the LV • Increased LV mass is also associated with an increased riskfor sudden cardiac death • Measurements of LV mass must be interpreted in the clinical context • In clinical practice, however, the presence of LVH is more commonly defined by wall thickness
  • 53. For producer information only. Not for use in sales situations. LVH: Assessment How do we assess LVH? • Look for underlying cause, any clinical symptoms/findings- primary reasons for LVH are hypertension and valve disorder • Mild- as good as standard/preferred, depending on history • Moderate- likely mildly to moderate ratable • Severe- highly rated, if we can offer
  • 54. For producer information only. Not for use in sales situations. Contact information: Cindy Miller: Miller.cindy@principal.com PH: 515-235-9285 Jon Leinen: Leinen.jon@principal.com PH: 515-247-6672 Contact for Questions
  • 55. For producer information only. Not for use in sales situations. Questions

Editor's Notes

  • #10: (CINDYs NOTE) --- there are 3 dimensional echo's but we rarely see them - I have never seen one --- the ultrasonographer simply uses a switch to change the transducers to go from M mode to the 2 D mode. Sound waves go out from the transducer to detect mass/ or an object and then the waves object they return back to the transducer and the sound waves are then converted into an image via the US machine and into a picture on the monitor – kind of like a depth or fish finder for those of you who fish
  • #11: CINDY’S NOTE---This view is where the aortic root LA measurement is completed . Visually the technician can see the MV function as it opens and closes , assess for MV prolapse or abnormalities of the chordae ;can look at the walls and for any abnormal structures . In general they are constantly reviewing and assessing the LV function and structures throughout the test and as they go form one view to another view
  • #12: CINDYS NOTE: -once again the technician just switches a button on the machine to change mode form US to Doppler mode The Doppler function sees color flow and can use audible signals as well images to provide a path of the blood flow through the heart. It also can be used to measure the velocity of the blood flow.
  • #13: Note this is a normal E/A ratio . E is > A . Ill talk about E A ratios more in depth - shortly PW doppler ALSO allow us to listen to specific portion of the blood as it moves through the heart which is addedd benefit to the cardioglgist AND can addl info about how the heart muscle squeezes and relaxes by AUDIO … I don’t have sound bite of that ……
  • #16: Can any one guess what this might be ? Remember LV is on right and its upside down Answer - VSD and trace AI or some impedence going out the AV ?
  • #17: L Diastole / how do I know --- MV open R Systole / MV closed= + mild Regurg the mosaic pattern on the L is because of the ^^ filling there is high velocity and this is nl the blue or red more solid colors = less velocity
  • #18: Cindy’s note---- the technician may mention on their report how difficult the test was to perform , indications for the test and so forth They will provide an assessment for the cardiologist to interpret however the final interpretation is up to the cardiologist // this is why we may see one part of the test that may note one finding and another part of the test in the final interpretation field with somewhat different notes –its important to take it all into consideration and read the dimensions not just the interpretation …because clinical assessment may be a bit different than what we would assess in the life insurance arena
  • #19: Cindys note – its not prognosticating its using critical thinking and applying it to our purpose which is different of course than what the persons MD may be assessing for
  • #20: CINDYS NOTE ---- SUBJECTive – LETS SAY A CARDIOLIGST CALLES LA OF 4.5 MILD LAE-- , BUT BY OUR CRIERIA a la OF 4.5 is not MILD . Re bod habitus and other phys deformiatis -- realy skinny boney folks , obese folks hard to scan ; T Those with kyphosis or COPD can be difficult to get good “ windows” too CINDYS NOTE – time specific example of that would be changes in a person’s fluid level and or whether or not they have been treated for htn or not adequately so one yr they may have sig lvh but it can improve the next yr so that’s why using the echo findings as a compliment to the current clinical status has a lot of value
  • #23: MAC -- In the elderly 10% men and nearly 16% of woman have MAC) Diastolic dys in elderly is very common and alsmost expected because of the generla loss of complaince all over there bodies We get old and brittle Thrombus can develop due to an akinetic LV after MI because the blood is allowed to stagnate because the wall doesn’t move normally / other things that cause thrombus are issues such as hypercoag states )
  • #24: CINDYS NOTE --often see this post op CABG – typically goes away on its own , sometimes have to have a percardiocentesis ; can be seen with inflammatory diseases as well as infectious diseases ; cancer also can cause an effusion
  • #25: Cindys note -- So in other words when a person at age 40 has mild LA enlargement – that is NOT common finding and we would look at more harshly and likely rate the 40 yr old but not likely rate a 70 yr old with the same finding
  • #26: Cindys note -- So in other words when a person at age 40 has mild LA enlargement – that is NOT common finding and we would look at more harshly and likely rate the 40 yr old but not likely rate a 70 yr old with the same finding
  • #27: Cindy to qualify the LVID 6 CM EX -- the heart suppose to be the size of your fist . So for example take the size of “SHAQS “fist .. You would expect it to be bigger than Betty Whites fist If his LA / LV were a bit bigger or just a tad out of the NORMAL on echo we may not be to awfully concerned if the rest of the echo and his clincial pic was NL But we would be concerned about Betty if the chamber sizes were enlarged or if her LA was showing some mod enlargement – NOTE **** RE LVID – SWISS IS A BIT MORE FORGIVING ON LV SIZE THAN LAE - spoke to Dr Clark about this and the 6.0cm speaks to MEN and the 6.0 begin what he said was mildly abnormal > he further noted that measurements should take into acct build / body size but typically don’t
  • #30: as much as 50 % CHF admissions is on account of Diastolic Dys gorwoing problem a lot of it due to obesity / Htn and our aging populatoinl and all that entails ( long time htn , longstanding valve dis , noncompliance we spoke about earlier )
  • #31: Eventually, if severe enough blood then backs up into the left atrium and, backward into the lungs.  In very severe cases it can back up and can cause pulmonary edema / and right sided heart failure The heart simply wont and cant accommodate the stretch because its so STIFF so it can fill up normally and things back up
  • #32: (CINDYS NOTE --- a lot of times SS diast dys very vague . Typically we see evidence of it in minor forms such as … example the Pt complains slight SOB / no longer to climb stairs like they used to in the absence of any pulm abnormalities
  • #33: CIndys note See Swiss for how to handle ^ BNP But as a reminder just look at a BNP as another tool to asssess how this persons diastolic and systolic fucntoin is doing overall
  • #37: Cindys note -- Loss of passive filling passive filing is represents as the E WAVE and so with loss of that the E wave is smaller And that could be because the LV is noncompliant /or restricted due to various disease processes and as a result the atria has to “stuff “ the blood in there against walls that wont expand and that is represented as increased velocity === increased A wave . SIDE NOTE -- general observ – also not the general enlargement of all of the chambers / LVH seen here -- which is typical in more advanced diastolic dysfuntion
  • #38: Cindys note grade I ----- we typcially rate the abvn echo findings and htn or whatever and that s our typcial case more often than not grade II ---- more problems ; the heart has kicked up compensatory mechanisims and I think what we want to look at is what type of SS is the person having , what is the Bp control and follow up etc and rate according to that grade III IV --- I would say your going to be looking at a sig rating and possible DCL
  • #39: Cindys note grade I ----- we typcially rate the abvn echo findings and htn or whatever and that s our typcial case more often than not grade II ---- more problems ; the heart has kicked up compensatory mechanisims and I think what we want to look at is what type of SS is the person having , what is the Bp control and follow up etc and rate according to that grade III IV --- I would say your going to be looking at a sig rating and possible DCL
  • #44: They treated him with diurectics and released him . Since then his BP has been under better control His Dr added a daily diuretic and Ca channel blocker plus lost a few #’s . Has no more sob , pedal edema resolved . Given this was 6 months how would we rate ? ANSWER --- T4 range . I think you have to be able to recognize that he had mild SS CHF that was likely associated with diastolic dys .