Processing of capsule
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- 2. CAPSULES Capsules are a solid dosage form in which the drug substance is enclosed in a water soluble shell or an envelope. A capsule shell is made from gelatin. The capsules are available both as hard capsule and soft capsule. 2
- 3. Advantages : 3 • The drug having unpleasant odour & taste can be administered by enclosing them in a tasteless shell. • Smooth become very slippery when moist &can be easily swallowed. • They are economical. Easy to handle &carry. • Release the medicament as and when desired in GIT. • They are made up from gelatin hence theyare therapeutically inert. • They are attractive inappearance. Available in various sizes . • Microencapsulation provides the sustained release dosageform.
- 4. Disadvantages: 4 1.The hygroscopic drugs cannot be filled in capsules. They absorb water present in the capsule shell &make it very brittle, which ultimately breaks intopieces. 2.The concentrated preparation which need previous dilution are unsuitable for capsules because it may lead to irritation in stomach if administered assuch.
- 5. Types of Capsules 5 1.Hard gelatin capsules 2.Soft gelatin capsules
- 6. 6 (cm3 ) SIZE Capacity in mg VOLUME 000 950 1.37 00 650 0.95 0 450 0.68 1 300 0.50 2 250 0.37 3 200 0.30 4 150 0.21 5 100 0.13
- 8. and calcium and kaolin are added to the powdered drug. These inert materials act as a protective sorbent .
- 12. SHAPES OF SOFT GELATINCAPSULES: 12
- 19. Sr.No. Hard Gelatin Capsule Soft gelatincapsule 1. Hard Gelatin Capsule shell consists of two parts 1.Body 2. Cap Soft gelatin capsule shell become asingle unit after sealing the two halves of the capsules 2. They are cylindrical in shape They are available in round , oval & tube like shapes 3. The contents of a hard gelatin capsules usually consist of the medicaments is the form of powder, beads or granules The contents of soft gelatin capsules usually consists of liquids or solids dissolved or dispersed in suitable excipients to give a paste like consistency. 4. These are prepared from gelatin ,Titanium dioxide, coloring agents and Plasticizer These are prepared from gelatin plasticizer (Glycerin or Sorbitol ) and a preservative 5. Capsules are sealed after theyare filled to ensure that the medicaments may not come out of the capsule due to rough handling Filing and sealing of soft gelatin capsules are done in a combined operation on machines
- 20. PROPERTIES OF THE POWDER TO BE FILLED IN CAPSULES:-
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