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An-Najah National University
Chemical Engineering Department
Microemulsion In Drug Delivery Systems
Prepared by:
Hana’a Tareq
Ibtihaj Awwad
Hadeel Suliman
Alaa Badran
Superior : Dr. Husni Odeh
Submitted to Chemical Engineering Department
Second Semester, 2010-2011
6/2/2024 1
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system

• Objectives.
• Microemulsion .
• Advantage and disadvantage of microemulsion.
• Solubility and Bioavailability.
• Earlier study of microemulsion in the drug.
• Materials.
• Experimental work.
• Results and discussion.
• Conclusion.
• Recommendation.
6/2/2024 2

This project aim to design and develop of microemulsion
drug delivery system .
 Improved the solubility and bioavailability of curcumin
drug by using microemulsion.
6/2/2024 3

 Microemulsion are liquid dispersions of water and oil that are
made homogenous, transparent and thermodynamically stable
by the addition of relatively large amounts of surfactant and co-
surfactant and having diameter of the droplets in the range of
100 – 1000 A (10 – 100 nm).
6/2/2024 4

 Microemulsions are thermodynamically stable system
and the stability allows self-emulsification of the system
whose properties are not dependent on the process
followed.
Microemulsion have low viscosity compared to other
emulsions.
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Microemulsion can improve the efficacy of a drug,
allowing the total dose to be reduced and thus minimizing
side effects.
 microemulsion are easy to prepare and require no
significant energy contribution during preparation.
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Use of a large concentration of surfactant and co-
surfactant necessary for stabilizing the nano-droplets.
 The surfactant must be nontoxic for using pharmaceutical
applications .
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Microemulsion stability is influenced by environmental
parameters such as temperature and pH. These parameters
change upon microemulsion delivery to patients.
6/2/2024 8
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery

Bioavailability of a drug is largely determined by the
properties of the dosage form.
The therapeutic index : ratio of the minimum toxic
concentration to the median effective concentration.
Low bioavailability is most common with oral
dosage forms of poorly water-soluble, slowly absorbed
drugs.
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Solubility : the amount of a substance that
dissolves in a given volume of solvent at a specified
temperature.
Poor aqueous solubility .
 High lipophilicity.
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Cyclovir
Labrasol (surfactant)
32%
Plurol Oleique
(
(co-surfactant
8%
Labrafac (oil)
10%
Water
50%
Bioavailability increases (12.78 times)
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Valsartan
Tween 80
(surfactant)
45%
PEG 400
(
(co-surfactant
45%
Capmul MCM
(oil)
10%
The release increased more than 90% when compared with
marketed formulation
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Glyburide (GLY)
Tween-20(sur).
Transcutol P (co-sur)
Capryol 90 (oil) Water
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6/2/2024 14

Microemulsion
systems
System no.1
Tween 20, Span 80
(Sur. Mix)
Jojoba oil(95%),
clove oil (5%)
System no. 2
Tween 20,
span80 (Sur. Mix.)
Clove oil
≃100%
6/2/2024 15

Curcumin
Preparation
Microemulsion
Preparation
Solubility Test
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Addition af
surfactant/
co-
surfactant
Addition of
oils
Addition of
water. Shaking.
6/2/2024
Chemical Engineering Department-Graduation
Project-Microemulsion Drug Delivery system 17

6/2/2024
Chemical Engineering Department-Graduation
Project-Microemulsion Drug Delivery system 18
Amount of
oil
0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8
Amount of
Sur. Mix
1.8 1.6 1.4 1.2 1 0.8 0.6 0.4 0.2
Table(1): Initial concentration values of oil and Sur. Mix. For the two systems

Drug solubility experiments
 Drug solubility experiments were carried out based on the
previous microemulsion experiments. It was experienced that
for:
First system jojoba oil and clove oil:
 surfactant/co-surfactant, oil, water(3.01%,27.07%,69.9%).
 surfactant/co-surfactant, oil, water (6%,24.28%,69.72%).
 surfactant/co-surfactant, oil, water(9.02%,21.11%,69.87%) .
6/2/2024 19

Second system clove oil :
 surfactant/cosurfactant,oil, water (3%, 27.14%, 69,86%).
 surfactant/cosurfactant,oil, water(6.02%,24.06%,69.92%).
 surfactant/cosurfactant,oil, water (9.01%,21.15%,69.84%) .
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 Due to the addition of water the shape and color of
emulsions were changed.(3, 2, 1 phases)
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0
10
20
30
40
50
60
70
80
90
100
0 10 20 30 40 50 60 70 80 90 100
Surfactant
%
Oil %
ME
Figure(1): Triangle Phase Diagram of oil , Sur. Mix. And Water
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 The highest solubility of curcumin 5mg/ml is found at
(20%,10%,70%): (S mix./oil/water) microemulsion system.
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 Microemulsion is excellent candidate as potential drug delivery
system.
 The microemulsion system occurred at (20% Smix ,10% oil
,70% water).
 The highest drug solubility of curcumine 5mg/ml is found at
(20%/10%/70%) : (Smix/oil/water) microemulsion system.
6/2/2024 24

1. Microemulsion method is one of the best method of drug
delivery to increase bioavailability of drug.
2. Deep study must be done for each material used in preparation
of ME.
3. Careful dealing with components while adding them to the
system.
6/2/2024 25

4. Use pre-calibrated devices for measuring amounts of
components.
5. Use suitable shaking device that offer gentle mixing
for several tubes that save time and effort.
6. Use Pure Water in Preparation of ME
6/2/2024 Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery system 26

6/2/2024 27
Chemical Engineering Department-Graduation Project-Microemulsion Drug Delivery
system

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