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PULMONARYPULMONARY
FUNCTIONFUNCTION
Dr. G. Praveen KumarDr. G. Praveen Kumar
Department of Pharmacy PracticeDepartment of Pharmacy Practice
Sri Ramachandra UniversitySri Ramachandra University
Pulmonary function
Pulmonary function
The Alveoli
• Approximately 300 million alveoli
• 1/3 mm diameter
• Total surface area if they were complete
spheres 85 sq. meters (size of a tennis court)
TOTAL LUNG CAPACITY (TLC):
The maximum amount the lungs
can be expanded with the
greatest inspiratory effort (vital
capacity plus residual volume)
VITAL CAPACITY (VC):
The maximum amount of air
expired after filling the lungs to
their maximum.
TIDAL VOLUME (TV):
The amount of air inspired or
expired with normal respiration
EXPIRATORY RESERVE VOLUME
(ERV):
The amount of additional air
that can be expired by forceful
expiration after the end of a
normal tidal expiration.
FORCED VITAL CAPACITY (FVC):
Maximum expiratory effort (as
rapidly and completely as
possible) following maximum
inspiration to total lung capacity
INSPIRATORY CAPACITY (IC):
The amount of air inspired
beginning at the normal
expiratory level and filling the
lungs to the maximum amount
(tidal volume plus inspiratory
reserve volume)
ONE-SECOND FORCED EXPIRATORY
VOLUME (FEV1):
The amount of air that is expired in
the first second of the forced vital
capacity. It may be expressed as
volume in L or as a percentage of
forced vital capacity
PEAK EXPIRATORY FLOW RATE
(PEFR):
The maximum flow rate that
occurs at any time during the
forced vital capacity
RESIDUAL VOLUME (RV):
Amount of air remaining in the
lungs following a forceful
expiration.
Pulmonary function
NORMAL VALUES FOR ADULTSNORMAL VALUES FOR ADULTS
Dead space volumeDead space volume 100-200 mL100-200 mL
Expiratory reserve volume (ERV)Expiratory reserve volume (ERV) 1-2 L1-2 L
Forced vital capacity (FVC)Forced vital capacity (FVC) 4 L*4 L*
Functional residual capacity (FRC)Functional residual capacity (FRC) 2-3 L2-3 L
Inspiratory capacity (IC)Inspiratory capacity (IC) 2-4 L2-4 L
One-second forced expiratory volume (FEV1)One-second forced expiratory volume (FEV1)
(> 70% FVC)(> 70% FVC)
3-4 L*3-4 L*
Peak expiratory flow rate (PEFR)Peak expiratory flow rate (PEFR) 9-10 L/sec9-10 L/sec
Residual volume (RV)Residual volume (RV) 1-2 L1-2 L
Tidal volume (TV)Tidal volume (TV) 500 mL500 mL
Total lung capacity (TLC)Total lung capacity (TLC) 6-7 L*6-7 L*
Vital capacity (VC)Vital capacity (VC) 4-5 L*4-5 L*
FVC
Interpretation of % predicted:
–80-120% Normal
–70-79% Mild reduction
–50%-69% Moderate reduction
–<50% Severe reduction
FEV1
Interpretation of % predicted:
• >75% Normal
• 60%-75% Mild obstruction
• 50-59% Moderate obstruction
• <49% Severe obstruction
PEAK FLOW METER
Its a small, hand-held device used
to monitor a person's ability to
breathe out air. It measures the
airflow through the bronchi and
thus the degree of obstruction in
the airways.
Pulmonary function
Pulmonary function
Gas diffusion tests
Gas diffusion tests measure the
amount of oxygen and other
gases that cross the lungs' air sacs
(alveoli ) per minute. These tests
evaluate how well gases are being
absorbed into your blood from
your lungs.
PLETHYSMOGRAPHY
The patient sits inside an airtight
box, inhales or exhales to a particular
volume and then a shutter drops
across their breathing tube. The
subject makes respiratory efforts
against the closed shutter causing
their chest volume to expand and
decompressing the air in their lungs.
Pulmonary function
MODERN DAYSMODERN DAYS
Pulmonary function
Restrictive Lung Disease
 Pleural
 Parenchymal
 Chest wall
 Neuromuscular
Obstructive Lung Disease
 Asthma
 COPD
- chronic bronchitis
- emphysema
 Bronchiolitis
 Upper airway obstruction
Obstructive Pattern — Evaluation
 Spirometry
 FEV1, FVC: decreased
 FEV1/FVC: decreased (<70%
predicted)
 Lung Volumes
 TLC, RV: increased
Restrictive Pattern – Evaluation
 Spirometry
FVC, FEV1: decreased
FEV1/FVC: normal or
increased
 Lung Volumes
TLC, RV: decreased
MEASUREMENT OBSTRUCTIVE RESTRICTIVE
Forced vital
capacity (FVC)
Decreased or
normal
Decreased
Forced expiratory
volume
in 1 second (FEV1)
Decreased Decreased or
normal
FEV1
/FVC ratio
Decreased Normal
Total lung capacity
(TLC)
Normal or
increased
Decreased
Asthma
 FEV1/FVC normal or decreased
Emphysema
FEV1/FVC <70%
TLC increased
Increased
compliance
 Chronic Bronchitis
 FEV1/FVC <70%
 TLC normal
 Normal compliance
Spirometry Patterns
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Pulmonary function

  • 1. PULMONARYPULMONARY FUNCTIONFUNCTION Dr. G. Praveen KumarDr. G. Praveen Kumar Department of Pharmacy PracticeDepartment of Pharmacy Practice Sri Ramachandra UniversitySri Ramachandra University
  • 4. The Alveoli • Approximately 300 million alveoli • 1/3 mm diameter • Total surface area if they were complete spheres 85 sq. meters (size of a tennis court)
  • 5. TOTAL LUNG CAPACITY (TLC): The maximum amount the lungs can be expanded with the greatest inspiratory effort (vital capacity plus residual volume)
  • 6. VITAL CAPACITY (VC): The maximum amount of air expired after filling the lungs to their maximum.
  • 7. TIDAL VOLUME (TV): The amount of air inspired or expired with normal respiration
  • 8. EXPIRATORY RESERVE VOLUME (ERV): The amount of additional air that can be expired by forceful expiration after the end of a normal tidal expiration.
  • 9. FORCED VITAL CAPACITY (FVC): Maximum expiratory effort (as rapidly and completely as possible) following maximum inspiration to total lung capacity
  • 10. INSPIRATORY CAPACITY (IC): The amount of air inspired beginning at the normal expiratory level and filling the lungs to the maximum amount (tidal volume plus inspiratory reserve volume)
  • 11. ONE-SECOND FORCED EXPIRATORY VOLUME (FEV1): The amount of air that is expired in the first second of the forced vital capacity. It may be expressed as volume in L or as a percentage of forced vital capacity
  • 12. PEAK EXPIRATORY FLOW RATE (PEFR): The maximum flow rate that occurs at any time during the forced vital capacity
  • 13. RESIDUAL VOLUME (RV): Amount of air remaining in the lungs following a forceful expiration.
  • 15. NORMAL VALUES FOR ADULTSNORMAL VALUES FOR ADULTS Dead space volumeDead space volume 100-200 mL100-200 mL Expiratory reserve volume (ERV)Expiratory reserve volume (ERV) 1-2 L1-2 L Forced vital capacity (FVC)Forced vital capacity (FVC) 4 L*4 L* Functional residual capacity (FRC)Functional residual capacity (FRC) 2-3 L2-3 L Inspiratory capacity (IC)Inspiratory capacity (IC) 2-4 L2-4 L One-second forced expiratory volume (FEV1)One-second forced expiratory volume (FEV1) (> 70% FVC)(> 70% FVC) 3-4 L*3-4 L* Peak expiratory flow rate (PEFR)Peak expiratory flow rate (PEFR) 9-10 L/sec9-10 L/sec Residual volume (RV)Residual volume (RV) 1-2 L1-2 L Tidal volume (TV)Tidal volume (TV) 500 mL500 mL Total lung capacity (TLC)Total lung capacity (TLC) 6-7 L*6-7 L* Vital capacity (VC)Vital capacity (VC) 4-5 L*4-5 L*
  • 16. FVC Interpretation of % predicted: –80-120% Normal –70-79% Mild reduction –50%-69% Moderate reduction –<50% Severe reduction
  • 17. FEV1 Interpretation of % predicted: • >75% Normal • 60%-75% Mild obstruction • 50-59% Moderate obstruction • <49% Severe obstruction
  • 18. PEAK FLOW METER Its a small, hand-held device used to monitor a person's ability to breathe out air. It measures the airflow through the bronchi and thus the degree of obstruction in the airways.
  • 21. Gas diffusion tests Gas diffusion tests measure the amount of oxygen and other gases that cross the lungs' air sacs (alveoli ) per minute. These tests evaluate how well gases are being absorbed into your blood from your lungs.
  • 22. PLETHYSMOGRAPHY The patient sits inside an airtight box, inhales or exhales to a particular volume and then a shutter drops across their breathing tube. The subject makes respiratory efforts against the closed shutter causing their chest volume to expand and decompressing the air in their lungs.
  • 26. Restrictive Lung Disease  Pleural  Parenchymal  Chest wall  Neuromuscular
  • 27. Obstructive Lung Disease  Asthma  COPD - chronic bronchitis - emphysema  Bronchiolitis  Upper airway obstruction
  • 28. Obstructive Pattern — Evaluation  Spirometry  FEV1, FVC: decreased  FEV1/FVC: decreased (<70% predicted)  Lung Volumes  TLC, RV: increased
  • 29. Restrictive Pattern – Evaluation  Spirometry FVC, FEV1: decreased FEV1/FVC: normal or increased  Lung Volumes TLC, RV: decreased
  • 30. MEASUREMENT OBSTRUCTIVE RESTRICTIVE Forced vital capacity (FVC) Decreased or normal Decreased Forced expiratory volume in 1 second (FEV1) Decreased Decreased or normal FEV1 /FVC ratio Decreased Normal Total lung capacity (TLC) Normal or increased Decreased
  • 31. Asthma  FEV1/FVC normal or decreased Emphysema FEV1/FVC <70% TLC increased Increased compliance  Chronic Bronchitis  FEV1/FVC <70%  TLC normal  Normal compliance
  • 33. Save Nature & Save Breathe… Thank You