Reasons of using caffeine with Paracetamol.
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Caffeine is added to some paracetamol medications to potentially increase the pain-relieving effects by acting as a mild stimulant that reduces fatigue. However, studies have shown that while caffeine is claimed to enhance the efficacy of paracetamol, it does not change the peak levels or absorption of paracetamol in the body. Combining caffeine with paracetamol may also increase the risk of side effects without providing significantly improved pain relief according to studies of the two substances together.
Reasons of using caffeine with Paracetamol.
- 1. Reasonsofusing caffeine with Paracetamol: Caffeine is a mild stimulant that helps reduce fatigue. Caffeine is used in this product to increase the pain relieving effects of acetaminophen. Caffeine is claimed to enhance the efficacy of paracetamol.1 However, peak plasma levels and extent of absorption are similar for paracetamol with caffeine and paracetamol alone.1 Compared with paracetamol alone, a person taking the combination of paracetamol with caffeine may be more likely to experience adverse effects than to get improved analgesia. Published trials have assessed the effect of combining caffeine with paracetamol compared with paracetamol alone in conditions including tension-type4 and non-migrainous headaches5, postoperative pain6,7, uterine cramping6 and primary dysmenorrhoea.