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HI TECH COLLEGE OF PHARMACY
CHANDRAPUR
NAME – MUKESH V KAPSE
CLASS – B PHARM 4th YEAR 8th SEM
ROLL NO – 32
SUBJECT – Biostatistic and Research
methodology
TOPIC –REGRESSION
CONTENTS
 Regression
 Types of Regression
 Application of Regression
 Regression Line
 Regression Equation
 Methods of determine regression Line
 Standard Errors of Regression
 References
REGRESSION
 It is a statistical tools used to calculate a continuous
dependent variable from various independent variable
and is commonly used for prediction and forecasting.
 Calculate unknown value from known values.
 According to Blair, regression analysis is define as the
measure of average relationship between two or more
variable in term of the original units of the data.
 This technique is used for modeling and analysis of
mathematical data.
 Regression analysis makes an equation to describe the
statistical relationship between one or more predictor
variable and response variable.
TYPES OF REGRESSION
 Simple
 Multiple
 Linear
 Non Liner
APPLICATION OF REGRESION
 It is use to know the relationship between different
variables.
 To find out the value of dependent variable from
value of independent variables.
 To find out coefficient of correlation , coefficient of
determination.
 r = ±√bzy x byz b=regression coefficient
r= correlation coefficient
 In corporate sector it is useful to check quality.
 To determine the statistical curve.
REGRESSION LINE
 The line of the best fit between two variable and stating the
common average relationship are known as regression
lines.
E.g.Variables X,Y
Regression lines X on Y
Y on X
 Consider X dependent variable Y-independent variable R
line is called as X on Y {used to estimate value of X that are
Unknown from known value of Y.}
 Consider Y dependent variable X-incident variable R line is
called as Y on X {used to estimate value of Y that are
Unknown from known value of X.}
REGRESSION EQUATION
These equations are use to show regression lines
 Regression equations of X on Y =
x=a+by, ∑x = Na + b∑y
 Regression equation of Y on X =
y=a+bx (b- slop, a- constant)
 b xy = r σ x / σ y
for X and Y regression coefficient (bxy)
σ – standard deviation
r – correlation of coefficient
 b yx = r σy / σx
 The regression line of Y on X gives the finest
possible values of Y for the given values of X.
 So this line is the sum of the square of deviations of
the calculated value of Y and observed value of Y is
minimum.
∑ (Yc - Yo)² = minimum
For X and Y ∑ (Xc - Xo)²=minimum
Where , c= calculated
o=observed
 If only one regression line exist between two
variables then r= ±1 (coefficient of correlation)
 If r=0 then both variables are independent variables
i.e. the line are perpendicular and values become
average.
PROPERTIES OF REGRESSION COEFFICIENT
 Coefficient of correlation is calculated by
determining the geometric mean of two regression
coefficient .
r =√bxy-byx r= +1 to –1
 Regression coefficient is independent from origin
but not from scale.
 If one regression coefficient is greter than 1 then
remaining must be smaller than 1.
 Both regression coefficient have sign (+ve/- ve)
 The value of coefficient of correlation is less than
the mean value of regression coefficient.
METHODS TO DETERMINE REGRESSION LINES
 Scattered diagram
 Least square method (curve fitting)
CURVE FITTING METHOD
 Process of constructing a curve or mathematical
function that has best fit to a series of data point
possibly subjective to constants.
 Curve fitting can involve either interpolation when fit
to the end data is required to smoothing in which
smooth function is constructed that approximately
fits the data.
 Fitted curve can be used as an aid for visualization
to interfere values of a function where no data is
available.
 To summarize the relationship among the two or
more variable.
METHOD OF LEAST SQUARES
 Uses to predict the behavior of dependent variables
 Provides the overall rationale for the placement of the
line squares of deviation ∑(Yc-Yo)²=minimum
 We minimize the sum of square of errors
 Application of this methods is to create a stright line that
minimise the sums of squares of errors that are
generated by the results of the associated equation.
a)Linear/Ordinary least square problem
b) Non-linear least square problem.
Regression line Y on X is
(y-yˉ )= byx (x-xˉ)
byx= r(σy)/(σx)
MULTIPLE REGRESSION
 One dependent variable (unknown)
 Two or more independent vaeiable(known)
 Eg: No of tablets /hr - dependent(unknown)
speed of machine
no of punches - independent(known)
 Y on X1 and X2
Y=a+b1x1 + b2x2
for N no of variables Y=a+b1x1 + b2x2……..bnxn
Where, b1 and b2- regression coefficient
a=constant
APPLICATIONS
 Use to handle multiple point at a point
 To determine a mathematical relationship between
random values (variables)
 To study relationship of multiple independent
variable.
 Use in biological, social , pharmaceutical science to
study possible relationship between variables
STANDARD ERRORS OF REGRESSION
 It is the measure of variation of an observation made around the
computed regression line.
 It is represents the average distance (difference)that the
observed values fall from the regression line.
 It should be smaller.
 If the value are smaller the observations are very close to
regression line.
 value =0 indicates, variation corresponding to the regression
line , the correlation is perfect.
 S yx = √∑(y-ye)²/N
 Where, Syx = Standard error of estimation of Y on X,
estimated value = Ye , N=No of Observations
APPLICATIONS
 For calculation of confidence intervals and
prediction intervals.
 The larger the value of Syx or Sxy then greter the
scatter on the line of regression.
 In this case the degress og correlation is very poor.
 In term of standard deviation ,
 Syx=σy² (1-r²) Sxy=σx² (1-r²)
 In term of variance
 Syx/(1-r ²) = σy² = variance
REFERENCE
 “Biostatistic and Research methodology” by Dr
Vinod Kumar, Dr Sanjay Sharma, Deepak Kumar,
Pee Vee Publication.
 “Biostatistic and Research methodology” by Prof.
Chandrakant Kokare, Nirali Prakashan.
Thank You

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Regression , Types of Regression, Application of Regression, methods

  • 1. HI TECH COLLEGE OF PHARMACY CHANDRAPUR NAME – MUKESH V KAPSE CLASS – B PHARM 4th YEAR 8th SEM ROLL NO – 32 SUBJECT – Biostatistic and Research methodology TOPIC –REGRESSION
  • 2. CONTENTS  Regression  Types of Regression  Application of Regression  Regression Line  Regression Equation  Methods of determine regression Line  Standard Errors of Regression  References
  • 3. REGRESSION  It is a statistical tools used to calculate a continuous dependent variable from various independent variable and is commonly used for prediction and forecasting.  Calculate unknown value from known values.  According to Blair, regression analysis is define as the measure of average relationship between two or more variable in term of the original units of the data.  This technique is used for modeling and analysis of mathematical data.  Regression analysis makes an equation to describe the statistical relationship between one or more predictor variable and response variable.
  • 4. TYPES OF REGRESSION  Simple  Multiple  Linear  Non Liner
  • 5. APPLICATION OF REGRESION  It is use to know the relationship between different variables.  To find out the value of dependent variable from value of independent variables.  To find out coefficient of correlation , coefficient of determination.  r = ±√bzy x byz b=regression coefficient r= correlation coefficient  In corporate sector it is useful to check quality.  To determine the statistical curve.
  • 6. REGRESSION LINE  The line of the best fit between two variable and stating the common average relationship are known as regression lines. E.g.Variables X,Y Regression lines X on Y Y on X  Consider X dependent variable Y-independent variable R line is called as X on Y {used to estimate value of X that are Unknown from known value of Y.}  Consider Y dependent variable X-incident variable R line is called as Y on X {used to estimate value of Y that are Unknown from known value of X.}
  • 7. REGRESSION EQUATION These equations are use to show regression lines  Regression equations of X on Y = x=a+by, ∑x = Na + b∑y  Regression equation of Y on X = y=a+bx (b- slop, a- constant)  b xy = r σ x / σ y for X and Y regression coefficient (bxy) σ – standard deviation r – correlation of coefficient  b yx = r σy / σx
  • 8.  The regression line of Y on X gives the finest possible values of Y for the given values of X.  So this line is the sum of the square of deviations of the calculated value of Y and observed value of Y is minimum. ∑ (Yc - Yo)² = minimum For X and Y ∑ (Xc - Xo)²=minimum Where , c= calculated o=observed  If only one regression line exist between two variables then r= ±1 (coefficient of correlation)  If r=0 then both variables are independent variables i.e. the line are perpendicular and values become average.
  • 9. PROPERTIES OF REGRESSION COEFFICIENT  Coefficient of correlation is calculated by determining the geometric mean of two regression coefficient . r =√bxy-byx r= +1 to –1  Regression coefficient is independent from origin but not from scale.  If one regression coefficient is greter than 1 then remaining must be smaller than 1.  Both regression coefficient have sign (+ve/- ve)  The value of coefficient of correlation is less than the mean value of regression coefficient.
  • 10. METHODS TO DETERMINE REGRESSION LINES  Scattered diagram  Least square method (curve fitting)
  • 11. CURVE FITTING METHOD  Process of constructing a curve or mathematical function that has best fit to a series of data point possibly subjective to constants.  Curve fitting can involve either interpolation when fit to the end data is required to smoothing in which smooth function is constructed that approximately fits the data.  Fitted curve can be used as an aid for visualization to interfere values of a function where no data is available.  To summarize the relationship among the two or more variable.
  • 12. METHOD OF LEAST SQUARES  Uses to predict the behavior of dependent variables  Provides the overall rationale for the placement of the line squares of deviation ∑(Yc-Yo)²=minimum  We minimize the sum of square of errors  Application of this methods is to create a stright line that minimise the sums of squares of errors that are generated by the results of the associated equation. a)Linear/Ordinary least square problem b) Non-linear least square problem. Regression line Y on X is (y-yˉ )= byx (x-xˉ) byx= r(σy)/(σx)
  • 13. MULTIPLE REGRESSION  One dependent variable (unknown)  Two or more independent vaeiable(known)  Eg: No of tablets /hr - dependent(unknown) speed of machine no of punches - independent(known)  Y on X1 and X2 Y=a+b1x1 + b2x2 for N no of variables Y=a+b1x1 + b2x2……..bnxn Where, b1 and b2- regression coefficient a=constant
  • 14. APPLICATIONS  Use to handle multiple point at a point  To determine a mathematical relationship between random values (variables)  To study relationship of multiple independent variable.  Use in biological, social , pharmaceutical science to study possible relationship between variables
  • 15. STANDARD ERRORS OF REGRESSION  It is the measure of variation of an observation made around the computed regression line.  It is represents the average distance (difference)that the observed values fall from the regression line.  It should be smaller.  If the value are smaller the observations are very close to regression line.  value =0 indicates, variation corresponding to the regression line , the correlation is perfect.  S yx = √∑(y-ye)²/N  Where, Syx = Standard error of estimation of Y on X, estimated value = Ye , N=No of Observations
  • 16. APPLICATIONS  For calculation of confidence intervals and prediction intervals.  The larger the value of Syx or Sxy then greter the scatter on the line of regression.  In this case the degress og correlation is very poor.  In term of standard deviation ,  Syx=σy² (1-r²) Sxy=σx² (1-r²)  In term of variance  Syx/(1-r ²) = σy² = variance
  • 17. REFERENCE  “Biostatistic and Research methodology” by Dr Vinod Kumar, Dr Sanjay Sharma, Deepak Kumar, Pee Vee Publication.  “Biostatistic and Research methodology” by Prof. Chandrakant Kokare, Nirali Prakashan.