This document summarizes sanctions programs administered by OFAC and discusses related challenges for the insurance industry. It notes that OFAC has enforcement authority over US persons and, in some cases, foreign subsidiaries of US companies. The document reviews past OFAC penalty actions against Aon, Gen Re and AIG for apparent sanctions violations involving transactions related to countries like Cuba and Iran. It concludes by emphasizing the importance for global insurers and reinsurers to implement robust sanctions compliance programs and exclusionary policy language given the risks of indirect exposures to sanctions targets.