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Alex.Holcombe@sydney.edu.au
@ceptional
http://www.slideshare.net/holcombea/
Reproducibility,
Open access,
&
Open science
9 September, 2015 Open Knowledge Foundation Australia, Melbourne
Reproducibility, open access, open science
https://osf.io/tvyxz/wiki/home/
Rule among early-stage venture
capital firms that “at least 50% of
published studies, even those in top-
tier academic journals, can't be
repeated with the same conclusions
by an industrial lab” - Prinz,
Schlange, & Asadullah. Nature Rev.
Drug Discov. 10, 712 (2011)
Bayer HealthCare :only about 25% of published
preclinical studies could be validated to the point
at which projects could continue
Amgen Fifty-three papers were deemed ‘landmark’
studies (see ‘Reproducibility of research
findings’)... scientific findings were confirmed in
only 6 (11%) cases
Academic knowledge is boxed
in by expensive journals.

Scientist meets Publisher
http://www.youtube.com/watch?v=GMIY_4t-DR0
+ Monopoly =
Profit
maximisation
US$11,000 per year;
$300 for a single issue
$
Profit Company Industry
10% BMW automobiles
23% Rio Tinto mining
25% Google search
29% Apple premium computing
35% Springer scholarly publishing
37% Elsevier scholarly publishing
http://wp.me/ph4jF-kmCC-BYAlexHolcombe
operating profit / revenue
http://shiny.retr0.me/journal_costs/
https://alexholcombe.wordpress.com/2015/05/04/four-reasons-to-
oppose-the-use-of-elseviers-services-for-the-medical-journal-of-australia/
How open science wins
Cultural change
• Early adopters
• Researcher training
• Advocacy, lobbying
• Journals strengthen
sharing policies
Tech work at grassroots
• Altmetrics
• Streamlining repositories
• Software for
reproducible research
CC-BY Alex Holcombe
Research funders ramp
up requirement that
code, data be posted
http://aoasg.org.au/2015/08/31/going-beyond-the-published-article-how-open-access-is-just-a-start/
Reproducibility, open access, open science
Article	
  borders	
  dissolve:	
  
Data,	
  commentary,	
  replication,	
  re-­‐analyses

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