This document discusses the need for a new operating system to guide human development given the failures of 20th century systems. It argues that resilience is needed at regional scales to counter vulnerabilities from factors like climate change and economic disruptions. The document explores cultivating a culture of resilience through principles like planning for change, expanding opportunities, developing rich relationships, designing for learning, and considering multiple scales. Regional approaches are emphasized as critical to bolstering resilience of social-ecological systems. Stories of innovation will show how resilience is being built in the region covering the West Coast of North America.