RESTful design rules promote best practices for building scalable APIs. The rules encourage contract-first design, establish standards, and reduce support costs. Key rules include using a uniform interface with URIs to identify resources, caching to improve performance, and making services stateless. Resources should have self-descriptive representations and link to related resources to allow navigation without hard-coded URIs. Common HTTP methods like GET, POST, PUT and DELETE should map to standard CRUD operations, and status codes indicate request outcomes.