ROP current understanding and management
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Retinopathy of prematurity (ROP) is a serious vascular eye disease affecting preterm infants, leading to blindness and severe visual impairment due to abnormal retinal blood vessel development. The document details the epidemiology, risk factors, screening, and treatment of ROP, emphasizing the need for early detection and intervention to prevent disability. It highlights the challenges in managing ROP, especially in developing countries like Bangladesh, where increased survival rates of preterm infants have led to a rising incidence of the disease.
ROP current understanding and management
- 1. Retinopathy of Prematurity (ROP): Current Understanding and Management
- 2. 1. M A MANNAN(Professor, Department of Neonatology, BSMMU, Dhaka), 2. SADEKA CHOUDHURY MONI (Assistant Professor, Department of Neonatology, BSMMU, Dhaka), 3. MOHAMMOD SHAHIDULLAH (Professor and Chairman, Department of Neonatology, BSMMU, Dhaka) BANGLADESH JOURNAL OF CHILD HEALTH (December-2014-vol-38-no-3)
- 3. Introduction Retinopathy of prematurity (ROP) is a vascular disease of the eye unique to preterm infants characterized by failure of retinal blood vessels to grow and develop normally. It results in severe visual impairment and blindness in newborns. Originally it was called retrolental fibroplasias (RLF), named for the end-stage of the disease in which a white, vascularized plaque could be seen behind the lens in an eye that was often completely blind.
- 4. Epidemiology ROP remains one of the leading causes of blindness in children in the United States and developed world. The epidemiology, natural history, and pathogenesis of ROP over a period of 15 years have been demonstrated in the largest study of the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYOROP). In that study, the reported incidence of ROP among infants <1250g was 65.8% . Approximately 6% of low birth weight infants (_1251 g) develop severe ROP that requires treatment to prevent visual los.
- 5. Continued.. For the developing world ROP is an emerging problem. In India in a prospective cohort of 552 preterm LBW newborns in a tertiary care hospital with or without risk factors, incidence of ROP was 22.3% and at 3 year follow up of those treated with laser photocoagulation, 9% were found blind due to retinal detachment. In Bangladesh reported incidence of ROP based on targeted screening program is not available. Follow up eye examination of preterm infants <33 weeks enrolled in another study demonstrated the incidence as 4.4%
- 6. Risk factors for ROP ROP is essentially a disease of prematurity. Other documented risk factors for ROP includes Cardio- respiratory instability, prolonged oxygen therapy,repeated episodes of apnoea of prematurity, anemia needing blood transfusion, neonatal sepsis etc. Risk is higher when the baby is severely ill.
- 7. History The First ROP case was described by Terry in 1942 in an infant who had grey, blood vessel-covered membranes behind the pupil. After that report, an epidemic of blindness occurred in the 1950s and 1960s among the survived tiny newborns in the United States. During that time high doses of oxygen was being used to treat apnoea of prematurity without monitoring. Uncontrolled supplemental oxygen was thought to be one of the causative factors of this devastating disease process.
- 8. Continued.. Attempts were made to curtail use of essential oxygen in the premature nursery. ROP did decrease but at the expense of increased mortality and higher incidence of cerebral palsy. With the advent of pulse oxymetry in 1970s, and beyond, oxygen therapy became controlled and it was thought that ROP would disappear. Unfortunately this proved to be untrue. With the advancement of neonatal services, sicker babies continued to survive and ROP again rose to frightingly high level. Therefore small gestational age and very low birth weight correlated more strongly with occurrence of ROP than did oxygen administration.
- 10. International Classification of Retinopathy of Prematurity (ICROP) The ICROP characterizes ROP by its Position (Zone) Extent (Clock hours) Severity (Stage) Presence or absence of “plus disease”
- 11. Location & Extent of ROP Zone 1: Circle with optic nerve at it’s centre and a radius of twice the distance from optic nerve to macula Zone 2: Concentric circle from edge of Zone 1 to ora serrata nasally and equator temporally Zone 3: Lateral crescent from Zone 2 to ora serrata temporally Extent of ROP described in 30 degree clock hours ( a total of 12 clock hours of 30 degree each)
- 13. Severity of ROP Stage 1 Presence of thin white demarcation line seperating vascular from avascular retina Stage 2 Addition of depth and width to the demarcation line separating vascular from avascular retina Stage 3 Presence of extraretinal fibrovas cular proliferation with abnormal vessels and fibrous tissue extending from ridge to vitreous Stage 4 Partial retinal detachment not involving macula (4A) and involving macula (4B) Stage 5 Complete retinal detachment
- 15. Plus Disease Presence of dilation and tortuosity of retinal vessels at posterior pole of eye. Also associoated with papillary rigidity and vitreous haze
- 16. Composite Categories of ROP “Threshold ROP” is defined as the presence of ROP in either zone I or zone II “Prethreshold ROP” Any ROP (less than threshold) in zone I is considered prethreshold “Aggressive Posterior ROP (AP-ROP)” A rapidly progressing, severe form of ROP, if untreated progresses rapidly to stage 5 ROP. The characteristics features of this type of ROP includes it’s posterior location, prominence of plus disease, and the ill- defined nature of the retinopathy. “No ROP” is a category with potential disaster if it is erroneously interpreted to mean that the retina is mature and no longer at risk for developing ROP.
- 17. Screening of ROP Whom to screen Timing of screening Frequency of Screening Termination of Screening Who should screen Methods of screening Place of Screening
- 18. Whom to screen The target population for screening in a country should be based incidence risk factors reported in that country. Current recommendation for a screening eye examination is for all infants born at less than or equal to 32 weeks gestation, and/or weighing less than 1500 g at birth. This is to ensure that all infants at significant potential risk are screened.
- 19. Timing of screening The initial eye examination should be conducted by 32 weeks’ postmenstrual age or 4 weeks’ chronological age whichever comes later. The rationale for this change comes from data that show that 90% of eyes that reach threshold do so between 33.6 and 42 weeks after conception. The mean age at which infants required treatment in the ET-ROP trial ( EARLY TREATMENT ROP TRIAL)was 35 plus or minus 2 weeks after conception.
- 20. Frequency of Screening Follow up is based on retinal findings which are classified according ICROP. The follow up schedule is as follows
- 21. Termination of Screening Criteria to stop further examination: Full retinal vascularization; this usually occurs at about 40th weeks of postmenstrual age and mostly completed by the 45th weeks. Regression of ROP noted.
- 22. Who should screen It should be performed by an ophthalmologist trained in indirect ophthalmoscopy with sufficient knowledge and experience to enable accurate identification of the location and sequential retinal changes of ROP. Other recommended personnel for screening examination are: Retina subspecialist General ophthalmologist trained in indirect ophthalmoscopy Trained neonatologist/ Pediatrician Trained Technician/ Nurses
- 23. Methods of screening 1. Indirect Ophthalmoscopy: Examination of the retina is performed using the binocular indirect ophthalmoscope (a head-mounted scope with light source) and a lens for focusing. 2. Use of RetCam and telemedicine Screening of ROP : The RetCam is a camera used to photograph the retina of infants. This camera do not require a dilated pupil or contact with the eye. Retinal images taken by the camera can be stored, transmitted to expert, reviewed, analyzed and sequentially compared over time and are useful for telemedicine purposes. The advantages of this method are that fewer screening ophthalmologists would be needed, making it ideal for more remote or rural areas.
- 25. RetCam
- 26. Place of Screening The ideal setting for screening is under a radiant warmer in the NICU, under the guidance of neonatologist. Discharged and stable babies may be screened in the trained ophthalmologist’s clinic or in the NICU.
- 27. ROP Screening In Bangladesh Neonatal health services have been extended throughout the country and due to improved neonatal services, increased numbers of preterm low birth weight babies are surviving. Therefore, ROP is an emerging problem. Although the magnitude of the problem has not been assessed in large scale, ROP screening has already been initiated. Some enthusiastic pediatric ophthalmologist with cooperation from neonatologist started to screen the tiny infants for ROP under their own initiative. Currently Neonatologists and ophthalmologist have come forward to conduct ROP screening in large scale in some reputed eye institutes and several Govt. and non-Govt. institutes with support from international organizations.
- 28. Treatment of ROP Treatment of ROP consists of destroying the portion of the retina that is unvascularized in order to preserve the rest of it. The rationale for why this works is thought to be that the avascular retina is a source of growth factors that promote abnormal neovascularization. When the avascular retina is destroyed, the release of growth factors ceases, and neovascularization involutes and regresses.
- 29. Indication of ROP treatment ET-ROP Recommendations for treatment:
- 30. Treatment modalities before retinal detachment Cryotherapy Laser Photocoagulation
- 31. Cryotherapy Cryotherapy was the mode of treatment in the absence of portable laser machines. In the late 1960s xenon arc photocoagulation and transscleral cryotherapy were used for the treatment of acute ROP. The Multicentre Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) for the first time established the beneficial effect of cryoablation of the peripheral avascular retina. It usually requires a general anaesthetic or sedation and ventilation. Cryotherapy is a painful and inflammatory procedure. Adverse effects include: conjunctivitis, eyelid swelling, hypotony, infection, laceration and haemorrhage of conjunctiva, preretinal and vitreous haemorrhage, glaucoma.
- 32. Laser Photocoagulation Head-mounted lasers rapidly became an attractive alternative to cryotherapy. The procedure can be done more often in the NICU without general anesthesia. Indirect laser photocoagulation is more convenient and technically easier to administer and is of particular advantage over cryotherapy in treatment of posterior disease. It permits a precise and relatively atraumatic delivery of treatment with less ocular and systemic adverse effects. The complications reported with laser are: cornea, iris and lens burns, hyphaema, retinal haemorrhages and choroidal rupture.
- 33. Treatment modalities after retinal detachment • Various procedures described are – Open-sky vitrectomy, Scleral buckling procedures (SBPs), Closed vitrectomy and lensectomy with or without SBPs. The success rate for surgery to reattach the retina in infants with ROP is poor as there is rapid degeneration of the photoreceptor cells after retinal detachment.
- 34. Other Modalities of Treatment Anti-VEGF therapies: Various anti-VEGF treatments ( bevacizumab) have been used in a small number of patients either by intra vitreal injection or injection into anterior chamber of the eye. These have yet to be fully evaluated. Gene therapy: Another method of producing local, ocular anti-VEGF therapy has used gene transfer via an intra vitreal injection of a control vector carrying the appropriate gene. This treatment has been reported as showing good results in animal testing but has yet to be used in humans.
- 35. Long-term Sequelae Of Retinopathy Of Prematurity The most serious long term-sequelae of ROP is blindness and this devastating disability affects mobility, education, developmental milestones, social interactions etc. Serious long term consequences can occur in children with severe ROP requiring treatment. Mild to moderate degree of peripherl vision loss (about 6.2% reduction) has been observed in the lasered Vs. unlasered eyes
- 36. Continued.. Eyes that required laser often have areas of traction or thinned retina that put them at increased risk of retinal detachment at older ages. Between 10 and 15 years of age, new retinal folds or detachments developed in 4.5% of the threshold eyes treated with cryotherapy, and 7.7% of threshold eyes not treated in the original CRYO-ROP cohort followed for 15 years. Frequent eye examinations are mandatory throughout life in all patients who had serious ROP in infancy.
- 37. Continued.. Other long term sequelae as reported with follow up of infants with ROP implications includes co requiring vitrectomy, cataract, amblyopia (loss of vision caused by disuse of one eye, often caused by a difference between the two eyes ), strabismus , early presenting myopia of high degree etc.
- 38. Conclusion and Recommendation Despite good efforts to control the risks of premature birth and improvement of prenatal care, premature birth cannot be avoided. But blindness and/or visual disability due to ROP is largely preventable. Timely identification through ROP screening and proper intervention in due time are the mainstay of preventing this devastating disability.
- 39. Continued.. Furthermore, while caring these tiny newborns, controlled oxygen exposure should be ensured. Finally raising awareness about this long lasting scar of premature birth among neonatologists, ophthalmologists and above all, among parents should not be under-estimated.
- 40. Thank You