This document outlines frameworks and tools for healthcare transformation. It discusses three frameworks: 1) system thinking which focuses on improving systems rather than individuals, 2) applying concepts from high reliability organizations (HROs) like aviation to achieve extremely low error rates, and 3) system redesign which restructures care delivery processes and outcomes. The document also introduces tools for transformation including standardized protocols, monitoring, and latent error detection. The overall message is that new rules and a multi-framework approach are needed to transform healthcare and improve outcomes.