Running Galera Cluster in Microsoft Azure involves setting up virtual machines and installing Galera Cluster software. This provides more control than Azure Database for MySQL, which uses asynchronous replication. While Azure Database for MySQL is fully managed, Galera Cluster in VMs supports the virtually synchronous replication that is its core feature. Cost estimates show running three Galera Cluster nodes in VMs costs less monthly than three hosted MySQL instances in Azure Database for MySQL.