The document describes a 50-year-old female patient presenting with a 15-day history of loose stools, fever, and rash all over the body, who was diagnosed with drug rash with eosinophilia and systemic symptoms (DRESS) syndrome likely induced by leflunomide, which caused hepatitis, renal involvement including acute interstitial nephritis and associated renal vasculitis. Despite treatment including steroids, the patient's condition deteriorated and she ultimately died from complications including perforated duodenal ulcers, sepsis, and multiple organ dysfunction syndrome.