Sachin sem 2 ppt
- 1. ROLE OF PREBIOTICS IN HUMAN HEALTH Presented BY MR. Sachin M. Uttarwar M. Pharm. Sem-II Department of Phrmaceutics 1/27
- 2. Introduction Probiotics Functions of probiotics Applications of probiotics Prebiotic Functions of prebiotics Prebiotic vs probiotics Types of prebiotics Applications of prebiotics Marketed formulations Conclusion Reference 2/27
- 3. o The concept of of prebiotic was introduced by Gibbson & Roberfroid in 1995 . o Probiotics and prebiotics in the diet can modify the composition and metabolic activites of microflora. o Prebiotics can be defined as non-digestible food ingredients or fiber that beneficially affect the body by selectively stimulating the growth and/or activity of a limited number of bacteria in the colon. o Microflora of the intestine complete digestion through fermantation, protect against pathogenic bacteria and stimulate the immune system 3/27
- 4. o Probiotic candidates, are live microbial food supplements. o Non-pathogenic and non-toxigenic o Retain viability during storage and survive passage through the stomach &small bowel. o capable of colonizing the intestinal tract to influence human health. Eg. Lactic Acid Bacteria ( LAB), Bifi dobacteria spp . 4/27
- 5. o Prevent potentially harmful bacteria attaching to gut lining. o Reduce the availability of nutrients for potentially harmful bacteria. o Improve mucous production form cell lining the gut. o Ongoing support of the immune system. o Bring down the pH in the colon. 5/27
- 6. o Improvement of lactose intolerance and other enzymatic effects. o Antibiotic associated diarrhoea. o Gastroenteritis. o Inflammatory bowel disease. o Intestinal infections and colonisation by pathogenic bacteria. o Traveller’s diarrhoea. o Colon cancer. 6/27
- 7. 7/27 Situation (prevention) Probiotic Ulcerative colitis E. coli Nissle 1917 Ulcerative colitis S. boulardii Crohn’s disease E. coli Nissle 1917
- 8. Prebiotics can be defined as non-digestible food ingredients or fiber that beneficially affect the body by selectively stimulating the growth and/or activity of a limited number of bacteria in the colon. Eg. Inulin and oligofructose 8/27
- 9. It is assumed that a prebiotic should increase the number or activity of bifidobacteria and lactic acid bacteria The importance of the bifidobacteria and the lactic acid bacteria (LABs) is that these groups of bacteria may have several beneficial effects on the host, especially in terms of improving digestion. prebiotics may thus also act as a bifidogenic factor and vice versa. It should help in increasing the absorption of certain minerals such as calcium and magnessium. 9/27
- 10. prebiotics probiotics Prebiotics non-digestible food ingredients fiber or carbohydrates Probiotics live active microraganism that when administered in adequate amount will have beneficially to its host. The powder from prebiotics can survive heat, cold,acid and even time. Probiotics are more fragile.they are vulnerable to heat and stomach acid. Prebiotics main role by nourishing the bacteria that lives in intestines. Probiotics fight the harmful bacterial speices present in the gut. Eg. Inulin and oligofructose Lactic Acid Bacteria ( LAB), Bifi dobacteria 10/27
- 11. Prebiotics escape enzymatic digestion in the upper gastrointestinal tract. Not excreted in the stools – indicating fermented by colonic flora Produce- a mixture of short-chain fatty acids (acetate, propionate butyrate), L-lactate, carbon dioxide and hydrogen. Stimulate Bifidobacteria. 11/27
- 12. Prebiotics are classified as soluble fiber. These type of soluble fibers are: 1. Inulin and oligofructose. 2. Fructo-oligosaccharides (FOS). 3. Galacto-oligosaccharides (GOS). 4. Other oligosaccharides- 12/27
- 13. Raw garlic – 17.5% Raw Banana – 1% Raw leak - 11.7% Raw dandelion greens -24.3% Raw onion - 5% Raw Asparagus – 5% Raw wheat bran - 5% 13//27
- 14. • Increase digestion of lactose metabolism. • Increase mineral absorption. • Increase HDL/LDL ratio. • Decrease serum lipids and blood cholesterol. • Decrease blood pressure. • Decrease glycemic response. 14/27
- 15. Fructooligosaccharides (FOS) The reduction of cholesterol levels and blood glucose levels, lowering of blood pressure. FOS are not digested by the human gastrointestinal tract, and when they reach the colon, they beneficially. stimulate the growth and strengthening of specific bacteria in the intestine. 15/27
- 16. Stimulation of the immune system of the host. Constipation relief. Decreased risk of osteoporosis. A reduced risk of atherosclerosis. Increasing stool weight in bowel movements. Increasing the frequency of bowel movements. Inulin has anticarcinogenic properties. 16/27
- 17. Polydextrose is partially fermented in the large intestine. Stimulating effect on the growth of Bifidobacterium . The addition of the inulin/GOS mixture were demonstrated in several studies with infants and children as the in creasing of the faecal percentage of Bifidobacteria. 17/27
- 18. Promotes the proliferation of bifidobacteria and the reduction of deteriorating bacteria . Thus causing beneficial effects to human health, such as liver detoxification by the reduction of toxic metabolites . Prevention of pathogenic diarrhea. On abdominal pain. 18/27
- 19. Effects on the intestinal flora. Most species of Lactobacillus used XOS, including Lactobacillus Fermentum. Incresing digestibility. Function and nutritional parameters in elderly. patients suggested a XOS 19/27
- 20. In a study of the incorporation of 0.5% of lactulose in formulations for infants. Long-standing liver cirrhosis, the administrationof milk fermented with bifidobacteria and lactulose resulted in the re-stabilization of beneficial microbiota Reduction of ammonia and free phenols in the blood. Used in the treatment of hepatic encephalopathy. 20/27
- 21. Lack of fiber will create more problems. For making prebiotics for the elderly suffer mainly from constipation,lactose intolerance and calcium absorption. The main thing prebiotics do is feed the probiotics bacteria thus keeps our diagestive system healthy and increase the immunity of the body. 21/27
- 22. Many baby food manufactures are adding prebiotics and probiotics to food. Infection cause in infant is diarrhea. They can be cured by brest milk contain the bifidobacterium which is good for growth of good bacteria in the colon. Prebiotics product can be given to the infant after the doctor recommendation. 22/27
- 23. Dairy products Breads Fruit juices Margarine Pasta Icecreams Milk, Biscuits Soft drinks in general 23/27
- 24. BRAND NAME MANUFACTURER GUTMESTER Powder Dr. Tobias ultimate prebiotic PREBIOTHERIVE powder Gundry MD Healthy Track Prebiotic, 60 Liquid Soft- Gels Irwin Naturals 60 Capsules Prebiotic INLIFE™ helthcare Pre-Probiotic Daily Health 60 Capsules Healthvit Pre-Probiotic DR. FORMULATED ORGANIC PREBIOTIC Garden of life 24/27
- 25. The various studies in clinical nutrition conducted over the past 20 years have established the indirect prebiotic ingredients in promoting healthy and balanced intestinal microbita. The administration of prebiotics reduce blood lipids and blood pressure, increases the synthesis and absorption of nutrients and has anti-carcinogenic. Prebiotics show interesting properties that have implications for the food processing industry. 25/27
- 26. 1 Monica jain et,al,.(2014) Malaya Journal of Bioscience 181-195 1 (3) 2 Glenn R Gibson (2007) Functional foods:. Prebiotic and Probiotic 1-5 3 Sherif M. Abed et.al., (2016) International Journal of Agriculture Innovations & Research 1319-1473 1 (5) 4 Biplab Bandyopadhyay and Narayan C. Mandal (2014) International Journal Of Current Microbiology & Applied Science. 410-420 3(3) 5 P. Marteau et.al., (2002) British Journal of Nutrition 153-157 87 26/27
- 27. 27