Sartorius Cell Line Development
- 1. Cell Line and Upstream Process Development Services
- 2. Cellca is a leading provider of Cell Line Development Services allowing customers easy open access to a cost effective reliable technology platform consistently delivering well characterised stable research clones from DNA to Research Cell Bank (RCB) in 4 months with titres upwards of 3.0 g/L in an easily scalable fed batch process. Key Benefits Speed `` From DNA to high-titre RCB in 4 months. Save up to 3 months by omitting the need for scalability studies. Track record `` More than 70 successfully completed projects using the Cellca CHO Expression Platform. Performance `` 95% of our developed cell lines deliver protein titres exceeding 3 g/L in a 12-14 day standard fed-batch process. Scalability `` Processes can be easily transferred and scaled-up to a range of bioreactors up to 2000 L. Customer focus `` Committed project teams and dedicated client manager’s make it their purpose to deliver service excellence and meet our client’s requirements. Cellca CHO Expression Platform Key Components Host Cell Line • CHO DG44 • Growth in suspension • Long-term stability • Fully documented history Expression Vector • DHFR system with high selection stringency • Optimal signal peptide • Freedom to operate Media System • Chemically defined • Free of animal components • Free of proteins & peptones • Optimised for Cellca cell lines Upstream Process Design • Robust • Easy to scale • Proven performance in various bioreactor systems Transfection & Pool GenerationVector Cloning Single Cell Cloning Clone Evaluation RCB Preparation From DNA to RCB in 4 months
- 3. Products `` mAbs (lgG1, IgG4, IgG2) `` Fc-fusion proteins `` Fab-related products `` Bispecific antibodies `` Biosimilars Scalability and Robustness Now Available Progress your product development cycle by utilizing Sartorius Stedim BioOutsource’s GMP cell bank manufacturing service. Refer to our MCB brochure for more info. Scalability from shake flask to 2000 L with minimal process development Cellca Track Record (Oct 2017) 2 g/L 3 g/L 4 g/L 5 g/L 6 g/L Pre-clinic & Phase 1 10 21 13 10 9 Phase 2 1 1 - - 1 Phase 3 1 - - - - Market Approval - - - - - 200 L BIOSTAT® STR 2000 L BIOSTAT® STR UNIVESSEL 5 L BIOSTAT® STR
- 4. Laupheim Sartorius Stedim Cellca Erwin-Rentschler-Str. 21 88471 Laupheim, Germany Phone: +49.7392.96648.10 | Fax: +49.7392.96648.29 Glasgow Sartorius Stedim BioOutsource 1 Technology Terrace, Todd Campus, West of Scotland Science Park, Glasgow, G20 0XA Phone: +44.141.946.4222 | Fax: +44.141.948.1291 Göttingen Sartorius Stedim Biotech August-Spindler-Straße 11, 37079 Göttingen, Germany Tel: +49.551.308.0 | Fax: +49.551.308.3289 www.sartorius-stedim.com Sartorius Stedim Cellca and BioOutsource Global Facilities For further contacts, visit www.cellca.de and www.biooutsource.com Laupheim, Germany Göttingen, Germany Glasgow, UK www.cellca.de/ Specificationssubjecttochangewithoutnotice.PrintedintheEUonpaperbleachedwithoutchlorine. PublicationNo.:S--1539-e160301·OrderNo.:85037-554-21·Ver.04/2017