PayPal has scaled its database infrastructure significantly over the years to support growth. It now has over 750 Oracle instances storing over 93 petabytes of data across various database types. There are challenges in scaling hardware resources like CPU, memory and I/O, as well as software limitations at high concurrency. PayPal addresses this through techniques like application design, database logical structuring, and scaling out horizontally through read replicas, sharding, domain isolation and active-active configurations. It also offloads some analytic workloads and is exploring new technologies like Exadata and Oracle 19c capabilities.