Selections from The 85% Solution
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This document provides information on MTHFR, a genetic mutation affecting the MethyleneTetraHydroFolate Reductase enzyme. It discusses how the mutation originated and spread, now affecting 85% of some populations. It describes how the mutation is actually a DNA transcription error that impacts methylation, an important enzyme function. The rest of the document outlines a 14-step protocol for treating homozygous MTHFR using various supplements to support methylation pathways.
Selections from The 85% Solution
- 1. Selections from: The 85% Solution By Dan Purser MD
- 2. ROOT CAUSES OF THE MTHFR MUTATION THE CURRENT HUMAN race lives and procreates a long time. I just had a daughter and was turning 50. Wow, was I crazy or what? It wasn’t that long ago that the average American lived to be in their late 20’s (three generations back), women were getting married in their teens and having babies, then dying in child birth. Only one out of ten children lived to adulthood – much lower in other countries. Now we’re living into our 90s regularly. With our longer life expectancy we are passing on more gene defects. There’s no doubt. It’s just the way it is. MTHFR (ACTUALLY called MethyleneTetraHydroFolate Reductase Enzyme Deficiency) came along in northern Europe several hundred generations ago and now has blown up (85% of the population carries a variant or at least a SNP of this gene mutation1 (stands for Single Nucleotide Polymorphism) or more appropriately called a transcription error, 5% carries both genes so are homozygous). And oddly enough 49% of the Latino or Hispanic population are carriers or have the MTHFR disease. Well, I guess it’s not really a disease or mutation – it’s actually just a DNA replication or copying problem called a TRANSCRIPTION ERROR. Wow, what an error. Methylation is probably THE most important enzyme function our body makes – it controls so much – and is deeply and inherently tied to our energy levels, both perceived and actual. You always have to wonder how mutations survive – especially cruddy ones like this one – studies have shown that it’s a survival gene mutation against colon cancer2 (crazy right? But I knew it had to give some type of x-‐man powers).
- 3. And why does your doctor not know about this or recognize it? I’m not sure. I think my (figurative) brothers and sisters in the medical field are just too busy with getting patients out of the office – they are overwhelmed seeing 60 patients a day (I never see more than 8). This book hopefully details the diagnosis and diseases and treatments of this disease more thoroughly to make it all more comprehensible for you and I. HOMOZYGOUS C677T PROTOCOL © BY DAN PURSER MD 1. Get your SpectraCell Comprehensive Micronutrient Panel -‐-‐ critical. 2. Get your Whole Blood Histamine Level. 3. Get your Homocysteine Level. 4. Start with Thorne Research OTC Basic Nutrients 2 Day Vegetarian Capsules™ at one per day (one capsules is the easiest and most natural way to get a TINY AMOUNT OF NATURAL FOLATE IN). 5. Add fish oil – Source Naturals Arcticpure™ Omega-‐3 1125 Fish Oil, 1,125mg – start with one per day (with meals) and after a few weeks go to twice a day (to prevent clotting and strokes and other thrombotic events) 6. Add probiotics -‐-‐ Natren™ Healthy Trinity Dairy Free Capsules – 2 in the morning or two at night – take with food. 7. Add one Doctor's Best™ Best Nattokinase (2,000 Fu), Vegetable Capsules, 90-‐Count – one per day to reduce clotting risk nautrally. 8. After 1-‐2 weeks, if no nausea, add or start on MegaFolinic™ Acid (try half a one per day) 9. After two week with no problems (nausea, aches, pains, etc.) add Homocystex™ Plus at one per day. Take first thing in the morning.
- 4. 10. After one week increase the Homocystex™ Plus to two per day 11. When your Homocystex™ Plus bottle is empty please switch over to Homocysteine Supreme™ (purchase from your doctor) at one per day – then immediately go to two per day. 12. Nauseated or feel funky? Add KAL™ NIACIN at 50 mg a dose (watch for flushing – just a weird side effect). Take up to 6 per day (they’re safe just may flush you into misery). 13. Is your Whole Blood Histamine level high? You aare n “undermethylator”. Start with methionine 500 mgm capsules first. If two each day are well tolerated then change to Doctor’s Best™ SAMe (and avoid extra methylfolate or especially folic acid!). 14. Is your Whole Blood Histamine level low? You are an “overmethylator”. Then add Active B12™ 1-‐3 per day – but do it SLOWLY. 15. After a few weeks and feeling the benefits (you will) please take an extra Homocysteine Plus™ at noon before lunch or with lunch. 16. After a few more weeks try FOUR Homocysteine Plus™ per day (2 in AM and 2 at lunch). If nausea or problems back it back down to two or three per day. 17. Add other vitamins as needed according to the SpectraCell® Results. 18. Don’t forget to add Niacin (50 mg) or B6 (in the form of hydroxycobalamin) if nausea occurs.
- 5. Patient 1 The genetic testing I ordered afterward – confirming my suspicions.
- 7. Patient 2
- 10. 1 No author listed. Accessed 13 May 2015 online at http://www.gbhealthwatch.com/GND-‐Cardiovascular-‐Diseases-‐ MTHFR.php 2 Osian G, Procopciuc L, et al. C677T and A1298C mutations in the MTHFR gene and survival in colorectal cancer. J Gastrointestin Liver Dis. 2009 Dec;18(4):455-‐60