The document discusses knowledge discovery from massive healthcare claims data through big data analytics. It aims to improve the cost-care ratio by reducing fraud, waste, and abuse. Various state-of-the-art analytics techniques are applied, including network analysis, text mining, and temporal analysis. Claims data from 48 million beneficiaries is analyzed along with other data sources to identify typical treatment profiles, costly areas, and fraudulent providers. The analyses transform the problem into well-known data mining problems and several approaches are presented for identifying fraud, waste and abuse in healthcare claims.