In a series circuit, there is only one path for electricity to flow through the loads. The total resistance is calculated by adding the individual resistances together. The same current flows through each load and the total voltage is the sum of the voltages across each load.
In a parallel circuit, there are multiple paths for electricity to flow. The total current is calculated by adding the currents through each load. The equivalent resistance is calculated using the individual resistances and Ohm's law.