Specification errors in regression arise from mistakes in variables or model assumptions, and can occur due to the inclusion of irrelevant variables, omission of relevant ones, or incorrect functional form. While including irrelevant variables does not bias estimators, it makes them inefficient, whereas omitting relevant variables results in biased and inconsistent estimators that invalidate hypothesis tests. Various tests, such as the Ramsey RESET test, are recommended to detect these errors and ensure robust regression models.