This document is the user's guide for IBM SPSS Amos 21. It provides an introduction and overview of Amos' features and capabilities. The guide includes tutorials for getting started with Amos and building path models, as well as examples of estimating variances and covariances, testing hypotheses, performing linear regression, and modeling with unobserved variables. It is intended to help users learn how to use Amos to specify and analyze structural equation models.