Major depression is an overwhelming sense of sadness and fatigue that interferes with functioning. It affects women twice as often as men and can occur in older adults, though it is not normal aging. Warning signs include feelings of guilt, changes in appetite and sleep, and loss of interest in activities. Coping strategies include seeking help from mental health professionals, maintaining social support, and exercise. Others can help by being aware of potential side effects from medications, encouraging social engagement and good nutrition, and being vigilant for suicidal thoughts or plans.
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