structure_skeletal_muscle.ppt
- 1. Structure and Function of Skeletal Muscle
- 2. Skeletal Muscle Human body contains over 400 skeletal muscles 40-50% of total body weight Functions of skeletal muscle Force production for locomotion and breathing Force production for postural support Heat production during cold stress
- 3. Structure of Skeletal Muscle: Connective Tissue Covering Epimysium Surrounds entire muscle Perimysium Surrounds bundles of muscle fibers Fascicles Endomysium Surrounds individual muscle fibers
- 5. Structure of Skeletal Muscle: Microstructure Sarcolemma Muscle cell membrane Myofibrils Threadlike strands within muscle fibers Actin (thin filament) Troponin Tropomyosin Myosin (thick filament)
- 7. Structure of Skeletal Muscle: The Sarcomere Further divisions of myofibrils Z-line A-band I-band Within the sarcoplasm Sarcoplasmic reticulum Storage sites for calcium Transverse tubules Terminal cisternae
- 9. The Neuromuscular Junction Site where motor neuron meets the muscle fiber Separated by gap called the neuromuscular cleft Motor end plate Pocket formed around motor neuron by sarcolemma Acetylcholine is released from the motor neuron Causes an end-plate potential (EPP) Depolarization of muscle fiber
- 10. Illustration of the Neuromuscular Junction
- 11. Motor Unit Single motorneuron & muscle fibers it innervates Eye muscles – 1:1 muscle/nerve ratio Hamstrings – 300:1 muscle/nerve ratio
- 13. Muscular Contraction The sliding filament model Muscle shortening occurs due to the movement of the actin filament over the myosin filament Formation of cross-bridges between actin and myosin filaments Reduction in the distance between Z-lines of the sarcomere
- 14. The Sliding Filament Model of Muscle Contraction
- 16. Cross-Bridge Formation in Muscle Contraction
- 17. Sliding Filament Theory Rest – uncharged ATP cross-bridge complex Excitation-coupling – charged ATP cross- bridge complex, “turned on” Contraction – actomyosin – ATP > ADP & Pi + energy Recharging – reload cross-bridge with ATP Relaxation – cross-bridges “turned off”
- 18. Muscle Function All or none law – fiber contracts completely or not at all Muscle strength gradation Multiple motor unit summation – more motor units per unit of time Wave summation – vary frequency of contraction of individual motor units
- 19. Energy for Muscle Contraction ATP is required for muscle contraction Myosin ATPase breaks down ATP as fiber contracts Sources of ATP Phosphocreatine (PC) Glycolysis Oxidative phosphorylation
- 20. Sources of ATP for Muscle Contraction
- 21. Properties of Muscle Fibers Biochemical properties Oxidative capacity Type of ATPase Contractile properties Maximal force production Speed of contraction Muscle fiber efficiency
- 22. Individual Fiber Types Fast fibers Type IIb fibers Fast-twitch fibers Fast-glycolytic fibers Type IIa fibers Intermediate fibers Fast-oxidative glycolytic fibers Slow fibers Type I fibers Slow-twitch fibers Slow-oxidative fibers
- 25. Comparison of Maximal Shortening Velocities Between Fiber Types
- 26. Histochemical Staining of Fiber Type
- 27. Fiber Types and Performance Power athletes Sprinters Possess high percentage of fast fibers Endurance athletes Distance runners Have high percentage of slow fibers Others Weight lifters and nonathletes Have about 50% slow and 50% fast fibers
- 29. Alteration of Fiber Type by Training Endurance and resistance training Cannot change fast fibers to slow fibers Can result in shift from Type IIb to IIa fibers Toward more oxidative properties
- 30. Training-Induced Changes in Muscle Fiber Type
- 31. Hypertrophy and Hyperplasia Increase in size Increase in number
- 32. Age-Related Changes in Skeletal Muscle Aging is associated with a loss of muscle mass Rate increases after 50 years of age Regular exercise training can improve strength and endurance Cannot completely eliminate the age- related loss in muscle mass
- 33. Types of Muscle Contraction Isometric Muscle exerts force without changing length Pulling against immovable object Postural muscles Isotonic (dynamic) Concentric Muscle shortens during force production Eccentric Muscle produces force but length increases
- 35. Illustration of a Simple Twitch
- 36. Force Regulation in Muscle Types and number of motor units recruited More motor units = greater force Fast motor units = greater force Initial muscle length “Ideal” length for force generation Nature of the motor units neural stimulation Frequency of stimulation Simple twitch, summation, and tetanus
- 37. Relationship Between Stimulus Frequency and Force Generation
- 38. Length-Tension Relationship in Skeletal Muscle
- 39. Simple Twitch, Summation, and Tetanus
- 40. Force-Velocity Relationship At any absolute force the speed of movement is greater in muscle with higher percent of fast-twitch fibers The maximum velocity of shortening is greatest at the lowest force True for both slow and fast-twitch fibers
- 42. Force-Power Relationship At any given velocity of movement the power generated is greater in a muscle with a higher percent of fast-twitch fibers The peak power increases with velocity up to movement speed of 200-300 degrees•second-1 Force decreases with increasing movement speed beyond this velocity
- 44. Receptors in Muscle Muscle spindle Detect dynamic and static changes in muscle length Stretch reflex Stretch on muscle causes reflex contraction Golgi tendon organ (GTO) Monitor tension developed in muscle Prevents damage during excessive force generation Stimulation results in reflex relaxation of muscle
- 45. Muscle Spindle