Study of consolidation parameters
- 1. STUDY OF CONSOLIDATION PARAMETERSPresented by : ADITYA SINGH M.PHARM 1st year (1st Sem.) Modern pharmaceutics Integral university
- 2. CONSOLIDATION An increase in the mechanical strength of the material resulting from particle or particle interaction.
- 3. CONTENT • Diffusion parameter • Pharmacokinetic parameters • Heckel plot • Similarity factors f1 and f2
- 4. DIFFUSION PARAMETERS • This is given by higuchi. • Q=KT • Where q is amount of drug released in time t per unit area, • K is higuchi constant • T is the time in hours • Application : modified release pharmaceutical dosage forms, transdermal systems and matrix tablets with water soluble drugs.
- 5. DISSOLUTION PARAMETERS • Dissolution is a process in which a solid substances solubilizes in a given solvent i.e mass transfer from the solid surface to liquid phase.
- 6. Dissolution parameters • Effect of agitation • Effect of dissolution fluid • Influence of pH of dissolution fluid • Effect of surface tension of the dissolution medium. • Effect of temperature of the dissolution medium.
- 7. Pharmacokinetic parameters • Pharmacokinetics is defined as the kinetics of drug absorption, distribution, metabolism, and excretion and their relationship with pharmacologic, therapeutic response.
- 8. PLASMA CONCENTRATION TIME PROFILE • Three important pharmacokinetic parameters: • Peak plasma concentration (Cmax). • Time of peak concentration (Tmax) • Area under curve (AUC)
- 9. Cmax • The point of maximum concentration of a drug in plasma is called as peak and the concentration of drug at peak is known as peak plasma concentration. • It is also called peak height concentration and maximum drug concentration. • Cmax is expressed in mcg/ml.
- 10. Tmax • The time for drug to reach peak concentration in plasma (after extravascular administration) is called the time of peak concentration. • It is expressed in hours. • Onset time and onset of action is dependent upon Tmax.
- 11. AUC • It represents the total integrated area under the plasma level- time profile and expresses the total amount of drug that comes in to systemic circulation after its administration. • AUC is expressed in mcg/ml X HRS.
- 12. Heckel plot
- 13. • The heckel analysis is most popular method of deforming reduction under compression pressure. • Powder packing with increasing compression load is normally attributed to particles rearrangement , elastic and plastic deformation and particle fragmentation.
- 18. Similarity factor F1 and F2
- 22. THANKING YOU