Superbugs and the role of diagnostics explained
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Superbugs are drug-resistant microorganisms that pose a significant global health threat, with common diseases like tuberculosis, HIV, and malaria increasingly showing resistance. Accurate diagnostics are crucial for effective treatment decisions and treatment monitoring, as poor treatment can lead to increased drug resistance. Urgent, coordinated action is needed from multiple stakeholders to prevent a post-antibiotic era where treatable infections could become fatal.
Superbugs and the role of diagnostics explained
- 1. SUPERBUGSTHE ROLE OF DIAGNOSTICS EXPLAINED & 1 of 171 of 17
- 2. Superbugs are microorganisms resistant to drugs that were previously effective. Before resistanc e After re sistanc e 2 of 17
- 3. WHAT’S MAKING THE PROBLEM WORSE? Antibiotics Healthcare Public Water supply Farming http://www.bbc.co.uk/guides/z8kccdm3 of 17
- 4. MOST COMMON DEADLY RESISTANT DISEASES 34 million people are living with HIV infection, out of which 8 million are receiving antiretroviral therapy (2011) Tuberculosis kills more people globally than any other infection. 219 million cases of malaria occurred worldwide and 660,000 people died from the disease (2010) Data suggests association between high levels of antiretroviral therapy and increased levels of HIV resistance. In 2012 extensively drug- resistant TB has been identified in 92 countries. Determining drug resistance for malaria is tough, yet antimalarial resistant variants have been threatening malaria control since the ‘70s. HIV TB MALARIA Source: WHO report on Antimicrobial resistance 20144 of 17
- 5. DETERMINING HEALTH WITH IN VITRO DIAGNOSTICS Diagnosis Treatment Monitoring Treatment Selection IVD results help identify a specific condition, its development and treatment selection. Treatment decisions such as medications, therapy or lifestyle changes are prescribed. Treatment is carried out using medical devices or pharmaceuticals. IVD results help check status of a disease. Did the treatment work? YesNo CURE 5 of 17
- 6. Superbugs have no respect for national borders. 6 of 17
- 7. Proper treatment starts with accurate diagnosis. 7 of 17
- 8. “Without urgent, coordinated action by many stakeholders, the world is headed for a post-antibiotic era, in which common infections and minor injuries which have been treatable for decades can once again kill,” “This is a somewhat grim picture, but I also want to point out that it’s not a hopeless picture.. if countries and other stakeholders see this report and respond to this report as a call of action.” -- Dr Keiji Fukuda, WHO’s Assistant Director-General for Health Security. 8 of 17
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- 10. GREATEST THREATS: MDR-TB* Total TB cases detected globally (in millions) Total of MDR-TB cases confirmed globally (in thousands) 1990 0 2 4 6 8 10 1995 2000 2005 2010 2011 2012 0 20 40 60 80 100 2005 2010 2011 2012 Source: WHO Global Tuberculosis Report 2013 *Multi-drug resistant tuberculosis 10 of 17
- 11. DIAGNOSING MDR-TB 2 WEEKS 2 HOURS Accelerating time of diagnosis 11 of 17
- 12. GREATEST THREATS: HIV Sources: WHO HIV Drug Resistance Report 2012 European AIDS Conference 2013 CDC Analysis 2013 US: 16% of newly diagnosed HIV patients carry resistant virus (2010) Europe: drug- resistant HIV increased by 35% in a decade (2003-2013) Eastern Africa: drug-resistant HIV increase at 29% per year (2012) Southern Africa: drug- resistant HIV increase at 14% per year (2012) 12 of 17
- 13. DIAGNOSING D-R HIV* Phenotypic testingGenotypic testing Do you have HIV? Do you have drug-resistant HIV? *Drug-resistant HIV 13 of 17
- 14. WHAT ARE PUBLIC BODIES DOING? 2001 16.10.2007 10.09.2013 30.04.2014 20.05.2014 WHO publishes Global Strategy for Containment of Antimicrobial Resistance Debate in the European Parliament on antibiotic resistance urges raise of awareness WHO publishes the first Global Report on AMR UK Ministry of Health publishes 6 year AMR Strategy Side-event at WHA on “The Fight Against Antimicrobial Resistance: Are Diagnosics Winning?” 14 of 17
- 15. WHAT IS THE INDUSTRY DOING? Develop tests that are necessary We work together with governments and supernational organisations: Make tests more accessible and available Empower healthcare professionals with data necessary to prescribe treatment 1. 2. 3. 15 of 17
- 16. medtechviews.eu MedTechViews.eu is an industry platform for dialogue about medical technologies between various actors in healthcare. Here’s how Superbugs: How diagnostics can help doctors reduce over-prescription of antibiotics Superbugs: Incentivising medtech to deliver solutions Submit your view to info@medtechviews.eu. Have your views shared with 4000+ readers/month. Read more about superbugs on medtechviews.eu P R O G R E S S 16 of 17