This document summarizes the background, methods, and goals of targeted evaluations of five programs supporting orphans and vulnerable children (OVC) in Kenya and Tanzania. The evaluations aimed to determine what intervention models and components are most effective and cost-effective in improving outcomes for OVC and their caregivers. The evaluations used case studies, surveys of children and caregivers, and analyses of program expenditures. Key outcomes examined included psychosocial well-being, education, health, HIV prevention, and legal protection. The findings provide evidence to guide decisions around scaling and improving OVC programs.