This document discusses challenges that life science students face in learning to use mathematics effectively in physics. It argues that some difficulties are due to epistemological misconceptions about the nature of knowledge in physics and ontological misconceptions about mathematical representations of physical concepts. The document proposes teaching students explicit "tools" and "core principles" to help them blend physical meaning with mathematical symbols. It provides examples of how chemical bonds and electric fields can be taught using appropriate ontological metaphors to help students understand abstract mathematical definitions.