Qwizdom is an audience response system that allows teachers to poll students and give quizzes using student and teacher remotes. The teacher creates a PowerPoint presentation with multiple choice or true/false questions in Qwizdom software. Students select answers using remotes, and Qwizdom can track individual responses or overall response statistics. The document provides an example library orientation presentation for grades 3-5 using Qwizdom, with modified questions for kindergarten using only two answer choices on remotes.