This study examined factors that influence paramedics' readiness to respond to chemical, biological, radiological, nuclear, or explosives (CBRNE) incidents. A survey of 663 Australian paramedics found that recent CBRNE training was strongly associated with higher reported readiness. Lower concerns about deployment and higher personal resilience were also linked to greater perceived competence in responding. Prior experience with CBRNE incidents reduced the impact of other predictive factors like gender and education level on response readiness. The findings suggest that training can increase paramedics' confidence in handling CBRNE events regardless of other individual characteristics or experience.