Thalassemia alpha and beta
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Thalassemia is a genetic blood disorder caused by mutations in the genes that control globin production. There are two main types - alpha thalassemia affects alpha globin genes, while beta thalassemia affects beta globin genes. Thalassemia severity depends on the number of affected genes, ranging from no symptoms to severe anemia requiring chronic blood transfusions. The thalassemia gene is maintained in populations where malaria is common due to heterozygote resistance to the disease.
Thalassemia alpha and beta
- 1. sheikh Amir Hamza Clinical biochemistry
- 2. Genetic blood disorder resulting in a mutation or deletion of the genes that control globin production. Normal hemoglobin is composed of 2 alpha and 2 beta globins Mutations in a given globin gene can cause a decrease in production of that globin, resulting in deficiency aggregates become oxidized damage the cell membrane, leading either to hemolysis, ineffective erythropoiesis, or both. 2 types of thalassemia: alpha and beta.
- 3. The thalassemia gene may be maintained in the human population, in part because of the greater immunity of heterozygous individuals against malaria and is found in parts of the world where malaria is common These include Southeast Asia, China, India, Africa, and parts of the Mediterranean.
- 4. mutation of 1 or more of the 4 alpha globin genes on chromosome 16 severity of disease depends on number of genes affected results in an excess of beta globins
- 5. 3 functional alpha globin genes No symptoms, but thalassemia could potentially appear in offspring
- 6. 2 functional globin genes results in smaller blood cells that are lighter in colour no serious symptoms, except slight anemia
- 7. 1 functional globin gene results in very lightly coloured red blood cells and possible severe anemia hemoglobin H is susceptible to oxidation, therefore oxidant drugs and foods are avoided treated with folate to aid blood cell production
- 8. no functional globin genes death before birth (embryonic lethality)
- 9. mutations on chromosome 11 hundreds of mutations possible in the beta globin gene, therefore beta thalassemia is more diverse results in excess of alpha globins
- 10. slight lack of beta globin smaller red blood cells that are lighter in colour due to lack of hemoglobin no major symptoms except slight anemia
- 11. lack of beta globin is more significant bony deformities due to bone marrow trying to make more blood cells to replace defective ones causes late development, exercise intolerance, and high levels of iron in blood due to reabsorption in the GI tract if unable to maintain hemoglobin levels between 6 gm/dl – 7 gm/dl, transfusion or splenectomy is recommended
- 12. complete absence of beta globin enlarged spleen, lightly coloured blood cells severe anemia chronic transfusions required, in conjunction with chelation therapy to reduce iron (desferoxamine)
- 13. Bone Marrow Transplants Replacing patient’s marrow with donor marrow First performed on thalassemia patient in 1981 Difficult, because donor must be exact match for recipient Even a sibling would only have a 1 in 4 chance of being a donor Cord Blood Transplants Rich in stem cells Also needs to be an exact match