Drivers connect applications to Cassandra clusters and maintain connections to nodes. They probe clusters to discover nodes, token ranges, and latency. Drivers are data-aware and can route queries to appropriate replicas or fail over if needed. Cassandra clusters can span multiple data centers for redundancy, workload separation, and geographic distribution of data and queries. Configuration files like cassandra.yaml and cassandra-env.sh are used to configure memory, data storage, caching, and other settings. Cassandra clusters should be provisioned on commodity servers using tools like cassandra-stress to test workloads and estimate needed nodes.