The document discusses the opportunities and challenges presented by the Fourth Industrial Revolution. It notes that new technologies like artificial intelligence, digital fabrication, and the fusion of physical and digital worlds are disrupting every industry. To take advantage of these changes, the US needs to invest in translational research, encourage pilot production, empower small manufacturers, and grow technical talent. Strategies like smart manufacturing, systems in a package, continuous manufacturing, and small-batch customized production can help startups leverage new technologies. Federal labs and manufacturing innovation institutes also provide resources to support commercialization. With the right focus on infrastructure, technology, institutions, skills, and demand, the US is well positioned to benefit from the Fourth Industrial Revolution.