The document discusses the reliability-based analysis and design of tunnel support systems under seismic effects, highlighting the importance of addressing uncertainties in material properties and load conditions. A case study of a 6-meter diameter tunnel located within alternating layers of silty sand and clay is analyzed, using response surface methodology (RSM) to evaluate the impact of these uncertainties on performance. The findings suggest that a thorough understanding of variabilities is essential for effective seismic design in geotechnical engineering.