Humanism emerged during the Renaissance and focused on classical learning and secular subjects rather than religious doctrine, key figures included Erasmus, Nebrija, Galindo, and Vives. The Protestant Reformation began with Luther and Calvin challenging Catholic doctrine which led to divisions in Christianity and political changes like Henry VIII splitting from Rome over his marriage to Catherine of Aragon. The Catholic Church responded with the Counter-Reformation and Council of Trent to reaffirm traditional theology.