This document provides information about depression, anxiety, stress, and how to manage them. It defines depression as a mood disorder causing persistent sadness and loss of interest. Depression is a leading cause of suicide and many experience impairment, though treatment is often effective. Anxiety is the body's reaction to stress and danger, manifesting physically and mentally. It is common and often related to life events or genetics. Stress is the body's response to demands and can affect the brain and body, though responses vary. Managing stress involves facing fears, relaxation, exercise, and healthy coping strategies.