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Using registry data to
improve surgical outcome
Rupert Pearse
Professor of Intensive Care Medicine
Queen Mary University of London
Disclosures
Research Grants
• Nestle Health Sciences
• Edwards Lifesciences
• Intersurgical
• Medtronic
Honoraria
• Nestle Health Sciences
• Edwards Lifesciences
• Medtronic
• Glaxo Smithkline
Using registry data to improve surgical outcome
Using registry data to improve surgical outcome
Isoflurane and the trial of n=1
Using registry data to improve surgical outcome
Not every
treatment should
be tested in a
randomised trial…
• 310 million surgical procedures worldwide
• True mortality rate is not known
• 3 million deaths each year
0.00
2.50
5.00
7.50
10.00
0.00
1.00
2.00
3.00
4.00
2009-2010 2010-2011 2011-2012 2012-2013 2013-2014
Numberofprocedures(millions)
90-daymortality(%)
Mortality (inclusive)
Mortality (intermediate)
Mortality (restrictive)
Frequency (inclusive)
How much surgery do we do?
Abbott & Fowler Brit J Anaesth 2017 in press
‘Unexplained variation is the
enemy of quality’
W. Edwards Deming
‘Failure to rescue’
• Death after a ‘treatable’ complication
• A measure of quality of healthcare
• Meant to avoid flaws in other quality metrics
• Has flaws just like other quality metrics
Ghaferi et al. Ann Surg 2009; 250: 1029–34.
Mortality rates vary but complication
rates don’t….?
An assessment of “failure to rescue” derived from routine NHS data.
Jones, Bottle & Griffiths; 2011
NHS data: Failure to rescue outliers
Surgical death rates vary in US hospitals
Ghaferi A. N Engl J Med 2009; 361: 1368-75.
Failure to Rescue
Hospitals ranked in quintiles by activity volume
Complications Mortality FtR
International Surgical Outcomes Study
Br J Anaesth 2016; 117: 601-609.
Mortality following cardiac surgery
in the UK
30-day survival following STEMI
NHS publishes surgical mortality data
Planned ICU admission and mortality
Kahan B et al. Intensive Care Med. 2017; 43: 971-79.
Kahan B et al. Intensive Care Med. 2017; 43: 971-79.
ICU bed provision and mortality
ICU admission for complications
Kahan B et al. Intensive Care Med. 2017; 43: 971-79.
Using registry data to improve surgical outcome
Enhanced Peri-Operative
Care for High-risk patients
Integrated Care Pathway adapted from:
Higher Risk Surgical Patient; RCS 2011
Trial design
• Stepped wedge randomised cluster trial
– Hospitals randomised in geographical clusters
– Integrated ethnographic & economics analyses
– Data capture via HQIP-NELA
• Intervention
– Integrated Care Pathway
– Local leadership by ‘champions’
– QI training, cluster meetings, web-based
resources
Stepped wedge randomised
cluster trial
Using registry data to improve surgical outcome
• Trial completed
• 20,000 patients in 93 hospitals
• National audit data
• Data governance regulations
• Results expected autumn 2017
Change invisible to the naked eye

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Using registry data to improve surgical outcome