VectorBase gene sets

This document provides an overview of VectorBase gene sets, including: - VectorBase provides official gene sets for mosquitoes (Anopheles, Aedes, Culex) and the tick Ixodes scapularis using automated gene modeling initially, with ongoing manual curation. - Gene sets are made using multiple approaches including aligning proteins to genomes, aligning ESTs, and ab initio gene prediction, which are then combined. - There are limitations to automated gene sets including missed or incomplete genes due to assembly gaps/errors and lack of evidence, as well as potential merges or splits of genes. Genome assembly issues like gaps, repeats, and polymorphisms can also impact gene sets.