This document discusses taking a spatial approach to analyze rising complexity from issues like population growth, urbanization, climate change, and aging in the global south. It argues that spatial modeling of scenarios can help test intervention options and enhance knowledge sharing. Key challenges covered include rapid urbanization, coastal flooding risks, health impacts of population aging, and developing spatial literacy for 21st century problems. The conclusion advocates that spatial science can help simulate, visualize, and connect analyses of vulnerabilities across interconnected human and environmental systems.