This chapter discusses perceptual and cognitive structure of space, including depth perception and costs of navigation. It covers various depth cues like occlusion, perspective, and shading. The principles of 2.5D design are outlined, which use depth selectively to support goals while ensuring critical information is accessible. Navigation through space has cognitive costs, and different modes of accessing information like traveling or online have different cost profiles. The chapter concludes that depth perception differs from patterns in the image plane and 2.5D design principles account for these differences.