This document discusses weaning patients from mechanical ventilation. It defines weaning as the transition from total ventilatory support to spontaneous breathing. Several criteria must be met for a patient to be considered for weaning, including improved oxygenation, hemodynamic stability, and inspiratory effort. The timing of weaning is important to avoid complications from premature or delayed removal of ventilation support. Methods of weaning discussed include gradual reduction of support and daily spontaneous breathing trials. Patients are considered ready for extubation if they can pass a spontaneous breathing trial without signs of respiratory distress.