This document discusses a study to identify and measure transformative science. The researchers developed metrics to analyze over 11 million MEDLINE articles from 1983-2012 to identify transformative work. They defined several metrics to measure qualities of transformative science like being radical in generating new paradigms, risky, multidisciplinary, and having wide impact. Their analysis found the metrics could identify transformative work distinct from just high impact work. Fields that were younger tended to be more transformative while older fields had higher overall impact. The researchers are continuing to validate the metrics.